A5069088913- Autophagy in Disease and Therapy
- Liver Disease and Transplantation
- Cannabis and Cannabinoid Research
- Liver Disease Diagnosis and Treatment
- Drug-Induced Hepatotoxicity and Protection
- Hepatitis C virus research
Shanghai Jiao Tong University
2018-2019
Ruijin Hospital
2018-2019
Acute or acute-on-chronic liver failure is a leading cause of death in diseases without effective treatment. Interleukin-22 (IL-22) currently clinical trials for the treatment severe alcoholic hepatitis, but underlying mechanisms remain to be explored. Autophagy plays critical role alleviating injury. The aim current study explore autophagy IL-22-mediated hepato-protective effect against acetaminophen (APAP)-induced Methods: A model acute injury induced by APAP was used vivo. IL-22...
Abstract Background and Aim Hepatitis B virus‐related acute‐on‐chronic liver failure (HBV‐ACLF) is characterized by acute deterioration of chronic disease with excessive inflammation. N‐myc STAT interactor (NMI), an inflammation‐mediated protein, involves in various inflammatory‐related diseases, but the role NMI development prognosis HBV‐ACLF remains to be elucidated. Methods Serum from healthy controls (HCs, n = 20), hepatitis (CHB, 50) patients, patients ( was determined using ELISA....