A5101490417- Traditional Chinese Medicine Studies
- Plant-based Medicinal Research
- Traditional Chinese Medicine Analysis
- HIV Research and Treatment
- Flavonoids in Medical Research
- Machine Learning in Healthcare
- Neurological Disease Mechanisms and Treatments
- Pharmacological Effects of Natural Compounds
- Advanced Photocatalysis Techniques
- HIV/AIDS Research and Interventions
- Medical Research and Treatments
- Tuberculosis Research and Epidemiology
- HIV/AIDS drug development and treatment
- Neurological Disorders and Treatments
- Immune Cell Function and Interaction
- Liver Disease Diagnosis and Treatment
- Healthcare and Venom Research
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Medical Imaging Techniques and Applications
- Copper-based nanomaterials and applications
- Biomedical Text Mining and Ontologies
- Medical Coding and Health Information
- Pneumonia and Respiratory Infections
- Diagnosis and treatment of tuberculosis
Qiqihar University
2025
Kunming Municipal Hospital of Traditional Chinese Medicine
2025
Indiana University – Purdue University Indianapolis
2025
Chinese PLA General Hospital
2024
Second Affiliated Hospital of Xi'an Jiaotong University
2023-2024
Dalian University of Technology
2024
State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation
2022
Modular Genetics (United States)
2022
Southern Medical University
2022
Air Force Medical University
2006-2021
Acute or acute-on-chronic liver failure is a leading cause of death in diseases without effective treatment. Interleukin-22 (IL-22) currently clinical trials for the treatment severe alcoholic hepatitis, but underlying mechanisms remain to be explored. Autophagy plays critical role alleviating injury. The aim current study explore autophagy IL-22-mediated hepato-protective effect against acetaminophen (APAP)-induced Methods: A model acute injury induced by APAP was used vivo. IL-22...
Hantaan viruses (HTNVs) are zoonotic pathogens transmitted mainly by rodents and capable of infecting humans. Increasing knowledge the human response to HTNV infection can guide development new preventative vaccines therapeutic strategies. Here, we show that infect CD8+ T cells in vivo patients diagnosed with hemorrhagic fever renal syndrome (HFRS). Electron microscopy-mediated tracking life cycle ultrastructure HTNV-infected vitro showed an association between notable increases cytoplasmic...
ABSTRACT Epithelial barrier dysfunction, critically involved in intestinal ischemia/reperfusion (I/R) injury, is significantly regulated by Nrf2‐mediated oxidative stress. Apigenin, a flavonoid commonly found fruits and vegetables with diverse biological properties, has an unclear impact on I/R injury. We hypothesize that apigenin improves dysfunction activating Nrf2 signaling. Thirty rats were randomly divided into five groups to establish model using superior mesenteric artery occlusion....
To assess the impact of albumin (Alb) administration on prognosis patients with acute kidney injury (AKI). Clinical data AKI in intensive care unit (ICU) were retrospectively analyzed from American Medical Information Mart Intensive Care-IV (MIMIC-IV), including demographic data, physiology score (APS), comorbidities, vital signs, laboratory indicators, treatment status, ICU length stay, and outcome indicators. The main measure is mortality. divided into Alb infusion group non based whether...
Medical coding is essential for healthcare operations yet remains predominantly manual, error-prone (up to 20%), and costly $18.2 billion annually). Although large language models (LLMs) have shown promise in natural processing, their application medical has produced limited accuracy. In this study, we evaluated whether fine-tuning LLMs with specialized ICD-10 knowledge can automate code generation across clinical documentation. We adopted a two-phase approach: initial using 74,260...
Abstract Background The World Health Organization End TB Strategy meant that compared with 2015 baseline, the reduction in pulmonary tuberculosis (PTB) incidence should be 20 and 50% 2020 2025, respectively. case number of PTB China accounted for 9% global total 2018, which ranked second high world. From 2007 to 2019, 854 672 active cases were registered treated Henan Province, China. This study was assess whether WHO milestones could achieved Province. Methods numbers Province from Chinese...
It has recently been demonstrated that toll-like receptors (TLRs) can recognize structural conserved motifs carried by circulating microbial products and lead to systemic immune responses in individuals infected with HIV-1. TLRs have detected CD8+ T cells at either a protein or RNA level. The role of on involved the host's during HIV-1 infection not well characterized. In this study, we analyzed expression TLR4, TLR5, TLR7, TLR8 infection. All these four could be cells, but only TLR7 from...
To assess the immunodominance patterns of HIV-1-specific cytotoxic T lymphocyte (CTL) responses and contribution these against peptides scanning optimal epitopes in chronic infection, we test CTL a panel 413 overlapping spanning HIV-1 Asian B sequence, including 147 corresponding to clade 49 chronically infected individuals by interferon-γ Elispot assay. A large variation recognition restricted same HLA class I allele is presented. Some are targeted frequently while other rarely recognized...
Machine learning models can reduce the burden on doctors by converting medical records into International Classification of Diseases (ICD) codes in real time, thereby enhancing efficiency diagnosis and treatment. However, it faces challenges such as small datasets, diverse writing styles, unstructured records, need for semimanual preprocessing. Existing approaches, naive Bayes, Word2Vec, convolutional neural networks, have limitations handling missing values understanding context texts,...
The purpose of this study is to assess predictive value the positron emission tomography (PET) with 18F-fluoro-deoxyglucose (FDG) for recurrence and survival after radiotherapy (RT) non-small cell lung cancer (NSCLC). One hundred forty-nine patients underwent pretreatment PET (n = 67) or PET/computed (CT) 82) definitive RT NSCLC. We evaluated relationship between maximum-pixel standardized uptake (SUVmax) clinical tumor features. Univariate Cox proportional hazard analysis (UVA) was used...
Background . Real world evidence is important for informing healthcare practice and developing medical products has gained broad interest in healthcare. Compound Kushen Injection (CKI) been widely applied into treatment of colon carcinoma (CC) China. Postapproval drug assessment related retrospective studies using electrical record (EMR) collected from hospital information system (HIS) one the most categories real‐world study (RWS). Based on HIS EMR, interrelationships combined medication...
Regulatory T cell (Treg) is a subset of CD4+ cells that play critical role in regulating the immune responses. Human immunodeficiency virus (HIV) infection associated with abnormalities and alters effector function. There are large number patients coinfected HIV hepatitis C (HCV). Here, we evaluated proportion Treg expressing CD25 FOXP3, status activation CD8+ 60 Chinese chronically infected and/or HCV. Furthermore, investigated influence highly active antiretroviral therapy (HAART) on level...