A5004813940- Liver Disease Diagnosis and Treatment
- Drug-Induced Hepatotoxicity and Protection
- Hepatitis B Virus Studies
- Drug Transport and Resistance Mechanisms
- Endoplasmic Reticulum Stress and Disease
- Pharmacogenetics and Drug Metabolism
- Liver Disease and Transplantation
- Liver Diseases and Immunity
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- COVID-19 Clinical Research Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Pharmacological Effects and Toxicity Studies
- Alcohol Consumption and Health Effects
- Diet and metabolism studies
- Hepatitis Viruses Studies and Epidemiology
- Hepatitis C virus research
- Nutrition and Health in Aging
- Animal Virus Infections Studies
- Adrenal Hormones and Disorders
- RNA Research and Splicing
- Immune responses and vaccinations
- Bariatric Surgery and Outcomes
- Lipid metabolism and biosynthesis
- Pharmacological Effects of Natural Compounds
Ruijin Hospital
2016-2025
Shanghai Jiao Tong University
2015-2025
Stanford University
2023-2025
Stanford Medicine
2023-2025
Acute or acute-on-chronic liver failure is a leading cause of death in diseases without effective treatment. Interleukin-22 (IL-22) currently clinical trials for the treatment severe alcoholic hepatitis, but underlying mechanisms remain to be explored. Autophagy plays critical role alleviating injury. The aim current study explore autophagy IL-22-mediated hepato-protective effect against acetaminophen (APAP)-induced Methods: A model acute injury induced by APAP was used vivo. IL-22...
Type 2 diabetes mellitus and metabolic dysfunction-associated steatotic liver disease (diabetic MASLD) frequently coexist worsen non-liver outcomes, but effective pharmacological therapies are limited. We aimed to evaluate the long-term effect of sodium-glucose cotransporter-2 inhibitor (SGLT-2i) on outcomes among patients with diabetic MASLD.
Backgrounds and Purpose Concurrent non-alcoholic fatty liver disease (NAFLD) in chronic hepatitis B (CHB) patients is a frequent increasingly concerning problem because of the NAFLD pandemic. Admittedly, can progress to steatohepatitis (NASH) severe fibrosis. Direct evidence fibrotic effect or NASH virus (HBV) infection remains lacking. We aimed reveal influence concurrent histologically proven diseases fibrogenesis with HBV infection. Methods performed retrospective cross-sectional study on...
Background & Aims: The Revised Electronic Causality Assessment Method (RECAM), a computerized update of the Roussel Uclaf Methodology (RUCAM), was recently proposed. In this study, we validated and compared utility RECAM RUCAM in Chinese patients with single conventional or herbal agent-induced liver injury. Methods: retrospective multicenter cohort well-established DILI non-DILI from 5 centers China, diagnostic performance by AUC analysis. consistency evaluated weighted kappa . major...
Information about the association of glucagon-like peptidase 1 receptor agonist (GLP-1RA) with liver and non-liver complications is insufficient in patients type 2 diabetes (T2D) metabolic dysfunction-associated steatotic disease (MASLD). We conducted a target trial emulation study to evaluate whether GLP-1RA decreases risk outcomes. Patients T2D MASLD initiating or dipeptidyl peptidase-4 inhibitor (DPP-4i) were included from 2013 2022 Merative™ Marketscan® Research Databases. Primary...
Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is an acute deterioration of function on chronic disease with immune disorder. Th22 cells and IL-22 were correlated inflammatory autoimmune diseases. However, in the pathogenesis HBV-ACLF remains to be elucidated. It was investigated correlation between prognosis HBV-ACLF.Seventy-one 65 hepatitis patients recruited. The peripheral frequencies Th22, Th17 Th1, or IL-17 determined, using flow cytometry ELISA, respectively....
Sodium taurocholate cotransporting polypeptide (NTCP), encoded by gene SLC10A1, is a receptor for hepatitis B virus (HBV). The aim of the current study was to investigate role NTCP polymorphisms in HBV susceptibility, cirrhosis and hepatocarcinogenesis. A total 1221 cases [including 866 chronic (CHB), 238 liver (LC), 117 hepatocellular carcinoma (HCC) patients] 1232 healthy controls (HCs) were recruited, 6 single nucleotide (SNPs) genotyped. Meta-analysis executed among 14591 CHBs 12396 HCs...
Abstract Non-alcoholic fatty liver disease (NAFLD) is characterized by excessive lipid accumulation in hepatocytes. The role of SENP3 metabolism, particularly NAFLD, unclear. Our results showed that hepatic was up-regulated NAFLD patients and an animal model vivo after loading hepatocytes with free acids (FFA) vitro . Intracellular determined silenced or overexpressed with/without FFA Confirming a for SENP3, gene silencing associated amelioration overexpression enhancement accumulation....
Currently, there is limited knowledge on the clinical profile of drug-induced liver injury (DILI) in Chinese children. We aimed to assess characteristics, suspected drugs, and outcomes associated with pediatric DILI China.
Detailed subgroup incidence rates for steatotic liver disease (SLD)-related hepatocellular carcinoma (HCC) are critical to inform practice and public health interventions but remain sparse. We aimed fill in this gap.
Long non-coding RNAs (lncRNAs) have recently been tightly linked to plenty of human diseases. However, knowledge acute-on-chronic liver failure (ACLF) related lncRNAs remains insufficient. In this work, we studied the role lncRNA nuclear enriched abundant transcript 1 (NEAT1) in pathogenesis ACLF. ACLF model was established by challenging D-galactosamine (D-GalN)/ lipopolysaccharide (LPS) i.p. rats with cirrhosis. The serum levels IL-1, IL-6, and HMGB1 were determined using ELISA....
Objective To evaluate the efficacy and safety of bicyclol in patients with drug-induced liver injury (DILI) using a nationwide database. Methods We retrospectively analyzed clinical data DILI DILI-R Propensity score matching was performed to balance control groups, alanine aminotransferase (ALT) recovery compared between two groups. Factors associated ALT were identified. Results The analysis included 25,927 patients. Eighty-seven cases group, 932 group. One-to-one propensity created 86...
Alcohol dehydrogenase 1B (ADH1B) and aldehyde 2 (ALDH2), members of the alcohol family, have important roles in liver diseases. The polymorphisms ADH1B rs1229984 ALDH2 rs671 hepatitis B virus (HBV) susceptibility persistent infection were investigated present study. Total 1,034 patients with [99 acute (AHB), 521 chronic (CHB), 158 acute-on-chronic failure (ACLF), 159 cirrhosis (LC), 97 hepatocellular carcinoma (HCC)] 1,262 healthy controls (HCs) Chinese Han population recruited, single...
To explore the categories of drugs causing hepatotoxicity and analyze clinical histological features corresponding drug-induced liver injury (DILI), in order to gain insights into potential diagnostic factors for DILI.A total 138 DILI patients treated at our hospital from April 2008 2010 were retrospectively analyzed. The responsible drug each case was recorded. Roussel Uclaf Causality Assessment Method (RUCAM) had been used diagnose DILI. Only cases that scored as highly probable or (more...
Abstract Sentinel surveillance system plays a key role in screening and monitoring emerging acute infectious diseases order to identify the suspected cases time. During SARS period 2003, fever clinics emerged many cities mainland China with purpose screen patients transfer confirmed designated hospitals for professional management. Shanghai city has reserved since then. Hence, clinicians front line are able respond quickly COVID-19 outbreak their accumulated knowledge experiences from past....
To set up the drug lymphocyte stimulation test (DLST), as a diagnosis means for DILI which was immunity idiosyncrasy, improve Diagnosis, level of DILI.For 59 patients who diagnosed DILI, we separated their PBMC, exploring to suspicious caused then use methods 3H-TdR test, according mixed degree clear PBMC count specific activated by drug.We also group, negative control and Positive at same time. Preliminary experiments including best dose PHA concentration drug. We 40 healthy group in our...
Non-alcoholic steatohepatitis (NASH) is a chronic liver disease characterized by hepatic steatosis, inflammation, and progressive fibrosis.Our previous study demonstrated that microRNA-552-3p (miR-552-3p) was down-regulated in the livers of patients with NASH alleviated glycolipid metabolic disorders.However, whether miR-552-3p affects progression remains unclear.In this current study, we found expression negatively correlated degree fibrosis inflammation patients.Interestingly, level...
The 2019 European Association for the Study of Liver (EASL) Clinical Practice Guidelines (hereinafter referred to as EASL Guidelines) extracted required evidence from detailed research materials, and rigorously graded condensed varying strengths into 32 recommendations 14 statements (recommendations reminders) drug-induced Injury (DILI). This guideline has important reference values helping clinicians further improve their understanding DILI level clinical diagnosis, treatment prevention;...