A5071173748- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Advanced Radiotherapy Techniques
- Brain Metastases and Treatment
- Management of metastatic bone disease
- Glioma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Head and Neck Cancer Studies
- Esophageal Cancer Research and Treatment
- Spinal Fractures and Fixation Techniques
- Radiation Therapy and Dosimetry
- Neuroendocrine Tumor Research Advances
- Radiomics and Machine Learning in Medical Imaging
- Spine and Intervertebral Disc Pathology
- Meningioma and schwannoma management
- Gastric Cancer Management and Outcomes
- Colorectal and Anal Carcinomas
- Effects of Radiation Exposure
- Medical Imaging Techniques and Applications
- Viral-associated cancers and disorders
- Esophageal and GI Pathology
- CNS Lymphoma Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
The University of Texas MD Anderson Cancer Center
2013-2023
Cone Health
2023
University of Oklahoma Health Sciences Center
2023
Emory University
2022
Harvard University
2018
Johns Hopkins University
2018
Scripps MD Anderson Cancer Center
2017
Baylor College of Medicine
1984-2016
Cancer Research And Biostatistics
2014-2015
Walker (United States)
2014
Object. The authors report data concerning the safety, effectiveness, and patterns of failure obtained in a Phase I/II study stereotactic body radiotherapy (SBRT) for spinal metastatic tumors. Methods. Sixty-three cancer patients underwent near-simultaneous computed tomography–guided SBRT. Spinal magnetic resonance imaging was conducted at baseline each follow-up visit. National Cancer Institute Common Toxicity Criteria 2.0 assessments were used to evaluate toxicity. Results. median tumor...
Brain metastasis (BM) is a leading cause of death from non-small-cell lung cancer (NSCLC). Reasoning that activation the epidermal growth factor receptor (EGFR) contributes to radiation resistance, we undertook phase II trial EGFR inhibitor erlotinib with whole-brain therapy (WBRT) in an attempt extend survival time for patients BM NSCLC. Additional end points were radiologic response and safety.Eligible had NSCLC, regardless status. Erlotinib was given at 150 mg orally once per day 1 week,...
Spinal stereotactic body radiation therapy (SBRT) is increasingly used to manage spinal metastases, yet the technique's effectiveness in controlling symptom burden of metastases has not been well described. We investigated clinical benefit SBRT for managing and reducing cancer-related symptoms.149 patients with mechanically stable, non-cord-compressing (166 lesions) were given a phase 1-2 study. Patients received total dose 27-30 Gy, typically three fractions. Symptoms measured before at...
Purpose This randomized trial compared outcomes of passive scattering proton therapy (PSPT) versus intensity-modulated (photon) radiotherapy (IMRT), both with concurrent chemotherapy, for inoperable non–small-cell lung cancer (NSCLC). We hypothesized that PSPT exposes less tissue to radiation than IMRT and thereby reduces toxicity without compromising tumor control. The primary end points were grade ≥ 3 pneumonitis (RP) local failure (LF). Patients Methods Eligible patients had stage IIB...
The purpose of this study was to determine the association insurance status with disease stage at presentation, treatment, and survival among top 10 most deadly cancers using SEER database.A total 473,722 patients age 18 64 years who were diagnosed one in database from 2007 2010 analyzed. A Cox proportional hazards model used for multivariable analyses assess effect patient tumor characteristics on cause-specific death.Overall, non-Medicaid less likely present distant (16.9%) than those...
To determine whether the standardized uptake value (SUV) of [(18)F]fluorodeoxyglucose by positron emission tomography could be a prognostic factor for non-small-cell lung cancer (NSCLC).One hundred sixty-two patients with stage I to IIIb NSCLC were analyzed. Overall survival (OS), disease-free (DFS), distant metastasis-free (DMFS), and local-regional control (LRC) calculated Kaplan-Meier method evaluated log-rank test. The significance was assessed univariate multivariate analyses.There 93...
The aim of this study was to determine if the response preoperative radiation and chemotherapy with continuous infusion 5-fluorouracil (5-FU) predictive for survival among patients locally advanced rectal cancer. Preoperative chemoradiation (CTX/XRT) that delivered 45 Gy in 25 fractions over 5 weeks 5-FU (300 mg/m2/day) given 117 patients. pretreatment stage distribution, as determined by endorectal ultrasound (u), included uT2N0 2%, uT3N0 47%, uT3N1 49%, uT4N0 2% cases; not performed 13%...
Object The aim of this study was to identify potential risk factors for and determine the rate vertebral compression fracture (VCF) after intensity-modulated, near-simultaneous, CT image–guided stereotactic body radiotherapy (SBRT) spinal metastases. Methods group consisted 123 bodies (VBs) in 93 patients enrolled prospective protocols metastatic disease. Data from these were retrospectively analyzed. Stereotactic 1, 3, or 5 fractions overall median doses 18, 27, 30 Gy, respectively....
Abstract BACKGROUND: In this phase 1/2 study, the authors tested hypothesis that single‐fraction stereotactic body radiotherapy (SBRT) for previously unirradiated spinal metastases is a safe, feasible, and efficacious treatment approach. METHODS: All patients were evaluated by multidisciplinary team. Spinal magnetic resonance imaging studies obtained before at regular intervals to define both target volume response treatment. SBRT was delivered peripheral dose of 16 24 grays in single...
Abstract BACKGROUND: The authors sought to improve the toxicity of conventional concurrent chemoradiation therapy for stage III nonsmall cell lung cancer (NSCLC) by using proton‐beam escalate radiation dose tumor. They report early results a phase 2 study high‐dose proton and chemotherapy in terms toxicity, failure patterns, survival. METHODS: Forty‐four patients with NSCLC were treated 74 grays (radiobiologic equivalent) weekly carboplatin (area under curve, U) paclitaxel (50 mg/m )....
Stereotactic body radiotherapy for previously irradiated, progressive spinal metastases may be a viable option in selected patients. The authors review prospective series of metastasis patients reirradiated with stereotactic radiotherapy.A total 59 63 tumors the spine were between 2003 and 2009. Spinal magnetic resonance imaging was performed both before treatment initiation at regular follow-up intervals. delivered to peripheral dose 30 grays (Gy) 5 fractions (6 Gy per fraction), or 27 3 (9...
OBJECTIVE Whether to administer or omit adjuvant whole-brain radiation therapy in conjunction with stereotactic radiosurgery (SRS) the initial management of patients one three newly diagnosed brain metastases is subject debate. This report provides data from a pilot study which neurocognitive function (NCF) was prospectively measured for treated SRS alone. METHODS Fifteen were Assessment NCF and magnetic resonance imaging scans performed. RESULTS At baseline, 67% had impairment on more tests...
The authors evaluated the efficacy, patterns of failure, and toxicity stereotactic ablative radiotherapy (SABR) for patients with medically inoperable, clinical stage I non-small cell lung cancer (NSCLC) in a prospective trial 7 years follow-up. Clinical staging was performed according to seventh edition American Joint Committee on Cancer TNM system.Eligible histologically confirmed NSCLC as determined using positron emission tomography were treated SABR (50 grays 4 fractions). primary...
<h3>Importance</h3> Proton beam radiotherapy (PBT) has the potential to reduce toxic effects in definitive management of locally advanced non–small cell lung cancer (NSCLC), but long-term prospective data are lacking. <h3>Objective</h3> To report final (5-year) results a study evaluating concurrent chemotherapy and high-dose PBT treat unresectable stage III NSCLC. <h3>Design, Setting, Participants</h3> In this open-label, single-group assignment study, with median follow-up 27.3 months for...
Abstract BACKGROUND: Concurrent chemoradiation therapy, the standard of care for locally advanced nonsmall cell lung cancer (NSCLC), can cause life‐threatening pneumonitis and esophagitis. X‐ray (photon)‐based radiation therapy (RT) often cannot be given at tumoricidal doses without toxicity to proximal normal tissues. We hypothesized that proton beam most patients with NSCLC could permit higher tumor less normal‐tissue than photon RT delivered as 3‐dimensional conformal (3D‐CRT) or...
PurposeFew studies to date have evaluated factors associated with the development of radiation pneumonitis (RP) in patients Hodgkin lymphoma (HL) and non-Hodgkin (NHL), especially treated contemporary techniques. These represent a unique group owing often large target volumes within mediastinum potential receive several lines chemotherapy that add pulmonary toxicity for relapsed or refractory disease. Our objective was determine incidence clinical dosimetric risk RP intensity modulated...