A5023856843- Fungal Biology and Applications
- Mycorrhizal Fungi and Plant Interactions
- Fungal and yeast genetics research
- Plant biochemistry and biosynthesis
- Biocrusts and Microbial Ecology
- Polysaccharides and Plant Cell Walls
- Neurobiology and Insect Physiology Research
- Microbial Metabolism and Applications
- Polyamine Metabolism and Applications
- Medicinal Plants and Bioactive Compounds
- Plant tissue culture and regeneration
- Meat and Animal Product Quality
- Plant Pathogens and Fungal Diseases
- Microbial Natural Products and Biosynthesis
- Enzyme-mediated dye degradation
- Plant-Microbe Interactions and Immunity
- Insect Utilization and Effects
- Plant and fungal interactions
- Chemical synthesis and alkaloids
- Slime Mold and Myxomycetes Research
- Probiotics and Fermented Foods
- Genetics, Aging, and Longevity in Model Organisms
- Advanced Nanomaterials in Catalysis
- Fermentation and Sensory Analysis
- Ubiquitin and proteasome pathways
Nanjing Agricultural University
2016-2025
Ministry of Agriculture
2008-2025
Ministry of Agriculture and Rural Affairs
2020-2025
National University of Singapore
2025
Northeast Forestry University
2025
Education University of Hong Kong
2024
Zhoukou Normal University
2024
Shandong Academy of Agricultural Sciences
2024
Shandong University
2021-2023
Air Force Medical University
2022
Plasma, the soluble component of human blood, is believed to harbor thousands distinct proteins, which originate from a variety cells and tissues through either active secretion or leakage blood tissues. The dynamic range plasma protein concentrations comprises at least nine orders magnitude. Proteins involved in coagulation, immune defense, small molecule transport, protease inhibition, many them present high abundance this body fluid, have been functionally characterized associated with...
The management of diabetic ulcer (DU) to rescue stalled wound healing remains a paramount clinical challenge due the spatially and temporally coupled pathological microenvironment that features hyperglycemia, biofilm infection, hypoxia excessive oxidative stress. Here we present pH-switchable nanozyme cascade catalysis (PNCC) strategy for spatial-temporal modulation in DU. PNCC is demonstrated by employing clinically approved iron oxide nanoparticles coated with shell glucose oxidase...
Summary V erticillium wilt in cotton caused by dahliae is one of the most serious plant diseases worldwide. Because no known fungicides or cultivars provide sufficient protection against this pathogen, . causes major crop yield losses. Here, an isolated endophytic bacterium, designated B acillus amyloliquefaciens 41 ‐1, exhibited greater than 50% biocontrol efficacy plants under greenhouse conditions. Through high‐performance liquid chromatography and mass analysis filtrate, we found that...
Heat stress (HS) influences the growth and development of organisms. Thus, a comprehensive understanding how organisms sense HS respond to it is required. Ganoderma lucidum, higher basidiomycete with bioactive secondary metabolites, has become potential model system due complete sequencing its genome, transgenic systems, reliable reverse genetic tools. In this study, we found that inhibited mycelium growth, reduced hyphal branching, induced accumulation ganoderic acid biosynthesis heat shock...
Ganoderma lucidum is one of the most important medicinal mushrooms; however, molecular genetics research on this species has been limited due to a lack reliable reverse genetic tools. In study, endogenous orotidine 5′-monophosphate decarboxylase gene (URA3) was cloned as silencing reporter, and four gene-silencing methods using hairpin, sense, antisense, dual promoter constructs, were introduced into G. through simple electroporation procedure. A comparison evaluation efficiency demonstrated...
Summary G anoderma lucidum has drawn worldwide interest with regard to its secondary metabolism and pharmaceutical activity. However, the development of such research been limited because a lack basic biological knowledge. Nicotinamide adenine dinucleotide phosphate oxidases (Nox) have recently highlighted many important roles in plants animals; however, exact functions Nox are still not fully understood fungi. In this study, we identified two N ox isoforms ( NoxA NoxB ) regulator, NoxR ....
To elucidate the mechanisms of fruit body development in H. marmoreus, a total 43609521 high-quality RNA-seq reads were obtained from four developmental stages, including mycelial knot (H-M), pigmentation (H-V), primordium (H-P) and fruiting (H-F) stages. These assembled to obtain 40568 unigenes with an average length 1074 bp. A 26800 (66.06%) annotated analyzed Kyoto Encyclopedia Genes Genomes (KEGG), Gene Ontology (GO), Eukaryotic Orthologous Group (KOG) databases. Differentially expressed...
Ganoderma lucidum is one of the most important medicinal fungi, but lack basic study on fungus has hindered further development its value. To investigate roles redox system in G. lucidum, acetic acid (HAc) was applied as a reactive oxygen species (ROS) stress inducer, and hydrogen-rich water (HRW) used to relieve ROS this study. Our results demonstrate that treatment 5% HRW significantly decreased content, maintained biomass polar growth morphology mycelium, secondary metabolism under...
Sepsis is a life-threatening organ dysfunction characterized by severe systemic inflammatory response to infection. Effective treatment of bacterial sepsis remains paramount clinical challenge, due its astonishingly rapid progression and the prevalence drug resistance. Here, we present decoy nanozyme-enabled intervention strategy for multitarget blockade proinflammatory cascades treat multi-drug-resistant (MDR) sepsis. The nanozymes (named MCeC@M Φ ) consist mesoporous silica nanoparticle...
Abstract Titanium sesquioxide (Ti 2 O 3 ) is drawing broad attention due to its fascinating physical properties and promising applications in the fields of energy, biomedicine, electronics, among others. Its richness mainly strongly correlated d 1 electrons on Ti 3+ sites. In stark contrast titanium dioxide (TiO ), has an ultra‐narrow bandgap (≈0.1 eV) at room temperature, resulting from strong correlation electrons. Distinct electrical optical are introduced , accompanied with varied...
The ability to acetylate lysine residues is conserved across organisms, and acetylation of plays important roles in various cellular functions. Maintaining intracellular pH homeostasis crucial for the survival enteric bacteria acidic gastric tract. It has been shown that eukaryotes can stabilize by histone deacetylation. However, it remains unknown whether utilize a reversible protein system adapt an environment. Here we demonstrate acetylation/deacetylation critical Salmonella enterica...
Ganoderma lucidum has high commercial value because it produces many active compounds, such as ganoderic acids (GAs). Salicylic acid (SA) was previously reported to induce the biosynthesis of GA in G. lucidum. In this study, we found that SA induces by increasing ROS production, and further research NADPH oxidase-silenced strains exhibited a partial reduction response SA, resulting induction increased production. Furthermore, localization shows mitochondria are sources production treatment....
ABSTRACT We previously reported that high temperature impacts ganoderic acid (GA) biosynthesis in Ganoderma lucidum via Ca 2+ . Therefore, to further understand the signal-regulating network of organism's response heat stress (HS), we examined role nitric oxide (NO) under HS. After HS treatment, NO level was significantly increased by 120% compared control conditions. The application a scavenger resulted 25% increase GA with found sample treated only Additionally, donor 30% lower content...