A5110514652- Advanced Nanomaterials in Catalysis
- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- Carbon and Quantum Dots Applications
- Advanced Drug Delivery Systems
- Extracellular vesicles in disease
- Nanocluster Synthesis and Applications
- MicroRNA in disease regulation
- Quantum Dots Synthesis And Properties
- RNA Interference and Gene Delivery
- Curcumin's Biomedical Applications
- Inflammatory Bowel Disease
- Ginger and Zingiberaceae research
- Electrochemical sensors and biosensors
- Cancer Research and Treatments
- Trace Elements in Health
- Graphene and Nanomaterials Applications
- Click Chemistry and Applications
- CRISPR and Genetic Engineering
- Nanoparticles: synthesis and applications
- Biosensors and Analytical Detection
- Plant Virus Research Studies
- Autophagy in Disease and Therapy
- Electrochemical Analysis and Applications
Xi'an Jiaotong University
2018-2025
First Affiliated Hospital of Xi'an Jiaotong University
2022-2025
Guangdong University of Technology
2024
Beijing Obstetrics and Gynecology Hospital
2023-2024
Capital Medical University
2023-2024
Dalian University
2024
Hohai University
2023-2024
Jinhua Academy of Agricultural Sciences
2024
University of Science and Technology
2024
Korea University of Science and Technology
2024
The use of nanotechnology for drug delivery has shown great promise improving cancer treatment. However, potential toxicity, hazardous environmental effects, issues with large-scale production, and excessive costs are challenges that confront their further clinical applications. Here, we describe a nanovector made from ginger-derived lipids can serve as platform the therapeutic agent doxorubicin (Dox) to treat colon cancer. We created nanoparticles ginger reassembled into nanovectors...
Nanozymes with superoxide dismutase (SOD)-like activity have attracted increasing interest due to their ability scavenge anion, the origin of most reactive oxygen species in vivo. However, SOD nanozymes reported thus far yet approach natural enzymes. Here, we report a carbon dot (C-dot) nanozyme catalytic over 10,000 U/mg, comparable that Through selected chemical modifications and theoretical calculations, show SOD-like C-dots relies on hydroxyl carboxyl groups for binding anions carbonyl...
Aim: To develop novel siRNA delivery system overcoming the limitations of synthetic nanoparticles, such as potential side effects, nonspecificity and economic production for ulcerative colitis therapy. Materials & methods: Nanoparticles composed edible ginger-derived lipid, termed lipid vehicles (GDLVs) were generated from ginger lipids through hydration a film, commonly used method liposome fabrication. The morphology, biocompatibility transfection efficiency GDLVs loaded with siRNA-CD98...
Combination therapy is an emerging strategy that under intensive preclinical investigation for the treatment of various diseases. CD98 highly overexpressed on surfaces epithelial cells and macrophages in colon tissue with ulcerative colitis (UC), which usually associated mucosal damage inflammation. We previously proved siRNA (siCD98)-induced down-regulation decreased severity UC to a certain extent. In effort further improve therapeutic efficacy, we aim simultaneously deliver siCD98...
Oral drug delivery is the most attractive pathway for ulcerative colitis [UC] therapy, since it has many advantages. However, this strategy encountered challenges, including instability of drugs in gastrointestinal tract [GT], low targeting disease tissues, and severe adverse effects. Nanoparticles capable tissue-targeted site-specific release may offer a unique therapeutically effective system that addresses these formidable challenges. We used versatile single-step surface-functionalising...
Plant-derived edible nanoparticles (PDNPs) are nano-sized membrane vesicles released by plants, such as grapefruit, ginger, broccoli, and lemon.
Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) characterized by diffuse inflammation of the colonic mucosa and a relapsing remitting course. The current therapeutics are only modestly effective carry risks for unacceptable adverse events, thus more approaches to treat UC clinically needed.For this purpose, turmeric-derived nanoparticles with specific population (TDNPs 2) were characterized, their targeting ability therapeutic effects against investigated systematically....
Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) of unknown etiology affecting the colon and rectum. Previous studies have found that reactive oxygen species (ROS) overproduction transmembrane glycoprotein CD98 (encoded by SLC3A2) upregulation played important roles in initiation progression UC. On basis this, biomimetic pH-responsive metal organic framework (MOF) carrier was constructed to deliver carbon nanodot-SOD nanozyme clustered regularly interspaced short...
Abstract Even though radiotherapy is the most important therapeutic strategy for colon cancer treatment, there an enormous demand to improve radiosensitivity in solid tumor destruction. For this purpose, a biomimetic nanoplatform based on hollow polydopamine nanoparticles (HP) with homologous targeting and pH‐responsive drug release properties designed. In work, HP constructed by using chelation competition‐induced polymerization then modified cell membrane. Hollow integrated Pt (Pt@HP) has...
Inflammatory bowel disease (IBD) is a chronic nonspecific with unknown etiology. Currently, the anti-inflammatory therapeutic approaches have achieved certain extent of effects in terms inflammation alleviation. Still, final pathological outcome intestinal fibrosis has not been effectively improved yet.In this study, dextran-coated cerium oxide (D-CeO2) nanozyme superoxide dismutase (SOD) and catalase (CAT) activities was synthesized by chemical precipitation. Our results showed that D-CeO2...
Ulcerative colitis (UC) is characterized by chronic inflammatory processes of the intestinal tract unknown origin. Current treatments lack understanding on how to effectively alleviate oxidative stress, relieve inflammation, as well modulate gut microbiota for maintaining homeostasis synchronously. In this study, a novel drug delivery system based metal polyphenol network (MPN) was constructed via coordination between epigallocatechin gallate (EGCG) and Fe
Overcoming adverse effects and selectively delivering drug to target cells are two major challenges in the treatment of ulcerative colitis (UC). Lysine-proline-valine (KPV), a naturally occurring tripeptide, has been shown attenuate inflammatory responses colonic cells. Here, we loaded KPV into hyaluronic acid (HA)-functionalized polymeric nanoparticles (NPs). The resultant HA-KPV-NPs had desirable particle size (∼272.3 nm) slightly negative zeta potential (∼-5.3 mV). These NPs successfully...
Nanoparticle (NP)-based combination chemotherapy has been proposed as a potent strategy for enhancing intracellular drug concentrations and achieving synergistic effects in colon cancer therapy. Here, we fabricated series of chitosan-functionalized camptothecin (CPT)/curcumin (CUR)-loaded polymeric NPs with various weight ratios CPT to CUR. The resultant cationic spherical CPT/CUR-NPs had desirable particle size (193-224 nm), relatively narrow distribution, slightly positive zeta-potential....
Nanoparticle (NP)-based combination chemotherapy has been proposed as an effective strategy for achieving synergistic effects and targeted drug delivery colon cancer therapy. Here, we fabricated a series of hyaluronic acid (HA)-functionalized camptothecin (CPT)/curcumin (CUR)-loaded polymeric NPs (HA-CPT/CUR-NPs) with various weight ratios CPT to CUR (1 : 1, 2 1 4 1). The resultant spherical HA-CPT/CUR-NPs had desirable particle size (around 289 nm), relative narrow distribution, slightly...
The ability of nanoparticles to target tumors and enable site-specific drug release provides a unique system for the delivery effective therapy with reduced toxic side effects. In this study, we used mesoporous silica (MSN) fabricate targeted that is responsive hyaluronidase (HAase). Following engraftment desthiobiotin onto surface MSN, streptavidin complex was generated, which functionalized biotin-modified hyaluronic acid (HA) controlled at cancer cells expressing HAase. Various...