A5051627278- Nanoplatforms for cancer theranostics
- Ubiquitin and proteasome pathways
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- DNA Repair Mechanisms
- Prostate Cancer Treatment and Research
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Wnt/β-catenin signaling in development and cancer
- Cancer-related Molecular Pathways
- interferon and immune responses
- Estrogen and related hormone effects
- Photoacoustic and Ultrasonic Imaging
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- Radiation Therapy and Dosimetry
- Pancreatic and Hepatic Oncology Research
- Metabolism, Diabetes, and Cancer
- Nanoparticle-Based Drug Delivery
- Glycosylation and Glycoproteins Research
- Monoclonal and Polyclonal Antibodies Research
- Bioinformatics and Genomic Networks
- Pancreatitis Pathology and Treatment
- Computational Drug Discovery Methods
First Affiliated Hospital of Xi'an Jiaotong University
2015-2025
Xi'an Jiaotong University
2010-2024
Indiana University School of Medicine
2012
First Hospital of Xi'an
2011
National Natural Science Foundation of China
2010
Queen Mary Hospital
2010
University of Hong Kong
2010
King's College Hospital
1993
University of Bologna
1993
Background and Objective Yes-associated protein (YAP) transcriptional co-activator with PDZ-binding motif (TAZ) are nuclear effectors of the Hippo pathway. Although they abundantly expressed in cytoplasm nuclei human colorectal cancer (CRC), related to tumor proliferation status, there have been few studies on predictive role YAP TAZ expression overall survival patients CRC. This study investigated both CRC colon cell lines, assessed their prognostic value. Methods Paraffin-embedded...
Abstract Even though radiotherapy is the most important therapeutic strategy for colon cancer treatment, there an enormous demand to improve radiosensitivity in solid tumor destruction. For this purpose, a biomimetic nanoplatform based on hollow polydopamine nanoparticles (HP) with homologous targeting and pH‐responsive drug release properties designed. In work, HP constructed by using chelation competition‐induced polymerization then modified cell membrane. Hollow integrated Pt (Pt@HP) has...
Vascular maturity and functionality are closely associated with tumor progression chemosensitivity. The antidiabetic agent metformin has shown its ability to inhibit angiogenesis in metastatic breast cancer models. However, it remains unclear if or how remodels the abnormal vasculature of cancer, while inhibiting angiogenesis.Metastatic models were constructed compare microvessel density (MVD), vascular function, lung metastasis chemosensitivity metformin-treated untreated mice. Protein...
// Li-Juan Wang 1 , Chen-Chen He Xin Sui Meng-Jiao Cai Cong-Ya Zhou Jin-Lu Ma Lei Wu 1,2 Hao Su-Xia Han and Qing Zhu Department of Oncology, the First Affiliated Hospital Medical School Xi'an Jiaotong University, Xi'an, Shaanxi Province, P.R. China 2 Center Radiotherapy, Provincial Tumor Hospital, Correspondence to: Zhu, email: Keywords : Intrahepatic cholangiocarcinoma, miR-21, PTPN14, PTEN, tumorigenesis Received November 07, 2014 Accepted January 20, 2015 Published February 28, Abstract...
Background: Necroptosis is closely related to the tumorigenesis and development of cancer. An increasing number studies have demonstrated that targeting necroptosis could be a novel treatment strategy for However, predictive potential necroptosis-related long noncoding RNAs (lncRNAs) in lung adenocarcinoma (LUAD) still needs clarified. This study aimed construct prognostic signature based on lncRNAs predict prognosis LUAD. Methods: We downloaded RNA sequencing data from The Cancer Genome...
Ferroptosis is an iron-dependent form of cell death triggered by the excessive accumulation lipid peroxides. Understanding regulatory mechanisms ferroptosis and developing strategies to target this process hold significant clinical applications in tumor therapy. Our study aims search for novel candidate genes involved regulation investigate their mechanism action We employed a CRISPR-Cas9 library perform genome-wide screen under inducer treatment conditions, revealing Scavenger Receptor...
The Hippo signaling pathway regulates cellular proliferation and survival, thus exerting profound effects on normal cell fate tumorigenesis. We previously showed that the pivotal effector of this pathway, YAP, is amplified in tumors promotes epithelial-to-mesenchymal transition (EMT) malignant transformation. Here, we report overexpression TAZ, a paralog human mammary epithelial cells EMT and, particular, some invasive structures 3D cultures. TAZ also leads to migration anchorage-independent...
Abstract BACKGROUND Glycogen synthase kinase 3 (GSK‐3) has been regarded as a potential therapeutic target for multiple human cancers. We previously reported that suppression of GSK‐3 activity with lithium chloride (LiCl) or small chemical inhibitors impaired cellular DNA synthesis and reduced cell proliferation in prostate cancer cells. Therefore, this study, we extended vitro findings to vivo settings order establish proof concept inhibition is feasible suppressing tumor growth vivo....
// Jiguang Ma 1,* , Wanxing Duan Suxia Han 1 Jianjun Lei 2 Qinhong Xu Xin Chen Zhengdong Jiang Ligang Nan Jiahui Li Ke Liang Zheng Wang Xuqi 3 Erxi Wu 4 Xiongwei Huo Department of Oncology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China Hepatobiliary Surgery, General Pharmaceutical Sciences, North Dakota State Fargo, ND, USA * These authors have contributed equally to this work Correspondence to: Han, email: Huo, Keywords : lipogenesis, cancer metabolism, ginkgolic acid...
// Su-xia Han 1,* , Xia Zhou 2,* Xin Sui Chen-chen He 1 Meng-jiao Cai Jin-lu Ma Yuan-yuan Zhang Cong-ya Chen-xian Armando Varela-Ramirez 3 and Qing Zhu Department of Oncology, The First Affiliated Hospital Xi'an Jiaotong University Medical College, Xi'an, Shaanxi, PR China 2 Biotherapy, Fourth University, Shenyang, Liaoning, Biological Sciences Border Biomedical Research Center, Texas at El Paso, Texas, USA * This authors have contributed equally to this work Correspondence to: Zhu, email:...
Abstract Carbohydrate antigen 19‐9 (CA19‐9) fails to demonstrate the predictive value for early detection pancreatic ductal adenocarcinoma (PDAC). Glypican‐1 (GPC1+) exosomes may serve as a noninvasive diagnostic tool detect stages of PDAC. Therefore, it is necessary explore serum GPC1 levels and determine whether serves novel biomarker PDAC patients. Blood samples were collected from 156 patients with PDAC, 199 non‐cancer controls, 240 other cancers. Serological examined by enzyme‐linked...
Abstract DrugGPT presents a ligand design strategy based on the autoregressive model, GPT, focusing chemical space exploration and discovery of ligands for specific proteins. Deep learning language models have shown significant potential in various domains including protein biomedical text analysis, providing strong support proposition DrugGPT. In this study, we employ model to learn substantial amount protein-ligand binding data, aiming discover novel molecules that can bind with This not...
As the most common type of renal cell carcinoma (RCC), clear (ccRCC) is highly malignant and insensitive to chemotherapy or radiotherapy. Although systemic immunotherapies have been successfully applied ccRCC in recent years, screening for patients who can benefit from these therapies still essential challenging due immunological heterogeneity patients. To this end, we implemented a series deep investigation on expression clinic data The Cancer Genome Atlas (TCGA) International Consortium...
Speckle-type POZ protein (SPOP) is an adaptor of the cullin 3-based ubiquitin ligase responsible for degradation oncoproteins frequently overexpressed in many tumor cells.Altered expression and somatic mutations SPOP have been observed various types with chromosomal aberrations, indicating a role maintaining genome stability, although detailed mechanism remains unclear.Here, we show that component DNA damage response (DDR).SPOP recruited to doublestrand break sites it forms nuclear foci...
To observe the effect of propranolol in cervical cancer and investigate mechanism effect． METHODS AND RESULTS: We found 5 direct protein targets (DPTs) (PRO) by DrugBank5.0 firstly. Next, we analyzed protein-protein interaction (PPI) network Kyoto Encyclopedia Genes Genomes (KEGG) pathways PRO DPTs result showed that was linked with cGMP/PKG pathway. Then, recognized top 38 upexpressed genes (CC) based original microarray datasets (GSE7803, GSE9750, GSE39001 GSE63514). Further, biological...
To elucidate the potential effect of promethazine on colorectal cancer (CRC) cells and underlying mechanism. Targets drug (PMTZ) were identified by DrugBank comparative toxicogenomic databases (CTD), Kyoto Encyclopedia Genes Genomes (KEGG) pathway analysis was performed with STRING software. The effects PMTZ predicted to be associated PI3K/AKT pathway. Cell Counting Kit 8 (CCK-8) assays used evaluate different concentrations proliferation various types CRC cells. Flow cytometry Western...
Insulin-like growth factor-binding protein-2 (IGFBP-2) is considered to be a human tumor antigen, and the tumor-specific immunity of IGFBP-2 has been reported in several types cancer. The purpose this study was evaluate whether autoantibodies can used as diagnostic markers lung results demonstrated that serum anti-IGFBP-2 autoantibody levels were significantly elevated cancer (mean, 1,633.318 ng/ml; median, 1,651.462 range, 342.732-4932.582 ng/ml) compared with benign disease (1,210.139,...
Aim . Sal-like protein 4 (SALL4), is reexpressed in tissues of a subgroup HCC associated with poor prognosis. Reports SALL4 serological levels linked to patients are meager and unclear the prognosis this malignancy. Methods Immunohistochemistry optical microscopy protocols were used examine presence liver from following patients: 38 HCC, 11 chronic hepatitis B virus (HBV), 13 cirrhosis, 12 healthy controls. Additionally, enzyme-linked immunosorbent assay (ELISA) was measure serum samples...
We explored the mechanism of aspirin in SCLC by dissecting many publicly available databases.Firstly, 11 direct protein targets (DPTs) were identified DrugBank 5.0. Then protein-protein interaction (PPI) network and signaling pathways DPTs analyzed. found that was linked with kinds cancer, most significant one is SCLC. Next, we classified mutation 4 (IKBKB, NFKBIA, PTGS2 TP53) using cBio Portal. Further, top 50 overexpressed genes Oncomine, interconnected STRING. Lastly, figured out 5...