A5100319956- CAR-T cell therapy research
- Thyroid Cancer Diagnosis and Treatment
- Ovarian cancer diagnosis and treatment
- Thyroid Disorders and Treatments
- Thyroid and Parathyroid Surgery
- Testicular diseases and treatments
- Ferroptosis and cancer prognosis
- Virus-based gene therapy research
- Acute Lymphoblastic Leukemia research
- Herpesvirus Infections and Treatments
- COVID-19 Clinical Research Studies
- Gastric Cancer Management and Outcomes
- Drug-Induced Hepatotoxicity and Protection
- Nanowire Synthesis and Applications
- Retinal and Optic Conditions
- Chronic Myeloid Leukemia Treatments
- Head and Neck Anomalies
- Cancer survivorship and care
- Cancer Immunotherapy and Biomarkers
- Cancer Treatment and Pharmacology
- Inflammatory Biomarkers in Disease Prognosis
- Soil and Water Nutrient Dynamics
- Liver physiology and pathology
- Neutropenia and Cancer Infections
- Mechanisms of cancer metastasis
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2025
West China Hospital of Sichuan University
2020-2025
Sichuan University
2020-2025
Xi’an Jiaotong-Liverpool University
2024-2025
Chongqing Medical University
2017-2025
Shanghai Innovative Research Center of Traditional Chinese Medicine
2024
Shanghai Skin Disease Hospital
2024
Tongji University
2024
University of Hong Kong
2024
Nano and Advanced Materials Institute
2024
Abstract CD19 chimeric antigen receptor (CAR) T-cell therapy has shown great success against B-cell acute lymphoblastic leukemia (B-ALL). Tandem and sequential CD19/CD22 dual-target CAR therapies have been developed to reduce the possibility of CD19-negative relapse; however, superior strategy is still uncertain. This study screened 219 patients with relapsed/refractory B-ALL who were enrolled in clinical trials either (NCT03919240) or (NCT03614858). The complete remission (CR) rates single...
As the most common type of renal cell carcinoma (RCC), clear (ccRCC) is highly malignant and insensitive to chemotherapy or radiotherapy. Although systemic immunotherapies have been successfully applied ccRCC in recent years, screening for patients who can benefit from these therapies still essential challenging due immunological heterogeneity patients. To this end, we implemented a series deep investigation on expression clinic data The Cancer Genome Atlas (TCGA) International Consortium...
Background Fruquintinib and regorafenib have been approved for the third-line therapy of metastatic colorectal cancer (mCRC) in China. However, at present, there is a lack head-to-head clinical trials on comparison efficacy safety between two drugs. Materials methods The data patients with mCRC who were treated fruquintinib or after standard chemotherapy Zhejiang Provincial People’s Hospital from October 2018 to November 2021 collected analyzed. primary endpoints overall survival (OS),...
Ammonia volatilization (NH3) and nitrous oxide (N2O) emission are the main underliers of nitrogen loss in farmlands, which can decrease use efficiency trigger environmental problems regarding greenhouse effects. Previous studies have regional limitations lack universal guiding significance, as they primarily based on individual experiments related to effects applying fertilizer maize. In this study, we performed a meta-analysis scale investigate overall impact application maize yield, N2O,...
In addition to technical barriers, public attitudes about the use of gene therapy have an important association with clinical implementation therapy.
Purpose: To systemically investigate the prognostic value of pre-ablation stimulated thyroglobulin (s-Tg) in children and adolescents with differentiated thyroid cancer. Methods: Clinical records from 118 were retrospectively reviewed. Results: The median age was 16 years, majority female (79.7%). All underwent total thyroidectomy received radioactive iodine therapy. After a follow-up 5.3 68 (57.6%) patients disease free, while 50 (42.4%) had persistent/recurrent disease. In multivariate...
Abstract Context The risk of persistent and recurrent disease in patients with differentiated thyroid cancer (DTC) is a continuum that ranges from very low to high, even within the 3 primary categories. It important identify independent clinicopathological parameters accurately predict clinical outcomes. Objective To examine association between pre-ablation stimulated thyroglobulin (ps-Tg) DTC investigate whether incorporation ps-Tg could provide more individualized estimate Design, Setting,...
Varicella-herpes zoster virus infection (VZV) is a major global health burden. This study aimed to evaluate VZV burden trends and cross-country inequalities. Age-standardized rates (ASRs) average annual percentage changes (AAPCs) of incidence, prevalence, mortality, disability-adjusted life years (DALYs) were analyzed. Trends stratified by age, sex, Sociodemographic Index (SDI). Decomposition analysis identified contributions aging, epidemiological changes, population growth. Cross-country...
Recently, with the gradual development of machine learning technology, more and people are trying to apply technology in various fields, finance is one important fields. This work investigates optimization cryptocurrency portfolios by combining Long Short-Term Memory (LSTM) time series forecasting traditional portfolio methods. The focus paper on using historical price data from past six years Bitcoin (BTC), Ethereum (ETH), Litecoin (LTC) train LSTM models, which then used predict prices...
Intrinsic capacity (IC), representing an individual's physical and mental abilities, is associated with adverse outcomes. Acute lower respiratory tract infections (LRTIs) contribute to poor long-term prognosis, yet effective assessment intervention strategies remain limited. Given the critical role of IC in aging population, understanding its prevalence impact older adults LRTIs crucial for improving management strategies. This study aims characterize domains patterns deficits assess their...
Abstract Purpose The 2019 novel coronavirus(COVID-19) mainly transmitted by person-to-person through inhalation of respiratory droplets. We report the laboratory results conjunctival PCR-tests and some clinical features these patients in shenyang China. Design This is a cross-sectional non-randomized study Subjects include 14 confirmly diagnosed cases, 16 suspected cases medical observed patients. Methods All with COVID-19 were admitted to designated hospital Shenyang, collected samples do...
Concurrent chemoradiotherapy is the preferred treatment for stage IVB cervical cancer; however, some patients experience a poor prognosis. The prognostic significance of body composition indicators, including visceral obesity, has been extensively investigated in with cancer. This study aimed to assess impact specifically pretreatment fat content, on survival outcomes We retrospectively analyzed clinical information from diagnosed cancer between 2010 and 2018. measured obesity...
Abstract Objective Neck lymph node (LN) metastasis is a common feature of paediatric papillary thyroid cancer, and LN ratio (LNR) defined as the number positive LNs excised to total removed. Unlike in adults, few data are available regarding clinical implication LNR population. Our purpose was investigate association with outcomes cancer. Design & Methods The study retrospectively reviewed 136 consecutive children adolescents cancer involvement but no initial distant metastasis. Initial...
Abstract Background We report the laboratory results of conjunctival PCR-tests and some clinical features these patients infected with COVID-19 in shenyang China.Methods collected samples to do tests by PCR.Medical observed were enrolled if they had symptoms. Then we analysed PCR order find relationships.Results The study include 14 confirmly diagnosed cases ,16 suspected medical patients.1 identified case coverted from case.22 removed because none them converted cases.1 recently.All...
The significance of human epidermal growth factor receptor 2 (Her2) and nucleus-associated antigen Ki-67 expression remains controversial in gastric adenocarcinoma (GaC). aim this study was to investigate the clinicopathologic prognostic Her2 resected GaC without distant metastasis.Malignant tissues data were obtained from 195 patients with non-metastatic GaC. Immunohistochemistry staining performed examine Ki-67; their association factors investigated using logistic regression, survival...