A5020186059- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Advanced Nanomaterials in Catalysis
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Graphene and Nanomaterials Applications
- Luminescence and Fluorescent Materials
- Photodynamic Therapy Research Studies
- RNA Interference and Gene Delivery
- Extracellular vesicles in disease
- Advanced Drug Delivery Systems
- Dendrimers and Hyperbranched Polymers
- Carbon and Quantum Dots Applications
- Cancer Immunotherapy and Biomarkers
- Advanced biosensing and bioanalysis techniques
- Advanced Polymer Synthesis and Characterization
- Photoacoustic and Ultrasonic Imaging
- Inflammasome and immune disorders
- Crystallography and molecular interactions
- Immune cells in cancer
- Plant-Microbe Interactions and Immunity
- Advancements in Transdermal Drug Delivery
- Polymer Surface Interaction Studies
- Curcumin's Biomedical Applications
- Immunotherapy and Immune Responses
Southwest University
2016-2025
Yibin University
2023-2024
Chang'an University
2023-2024
Hainan Normal University
2021-2024
Chongqing University of Arts and Sciences
2022-2024
Hunan University
2023-2024
State Key Laboratory of Chemobiosensing and Chemometrics
2023-2024
Kunming University of Science and Technology
2024
Air Force Medical University
2023
State Key Laboratory of Silkworm Genomic Biology
2018-2022
The absence of tumor antigens leads to a low response rate, which represents major challenge in immune checkpoint blockade (ICB) therapy. Pyroptosis, releases and damage-associated molecular patterns (DAMPs) that induce antitumor immunity boost ICB efficiency, potentially injury when occurring normal tissues. Therefore, strategy highly efficient agent tumor-specific pyroptosis but reduce tissues is urgently required. Here, smart microenvironmental reactive oxygen species (ROS)/glutathione...
A hypoxic and acidic tumor microenvironment (TME) plays a significant role in cancer development through complex cellular signaling networks, it is thus challenging to completely eradicate tumors via monotherapy. Here, PEGylated CoFe2O4 nanoflowers (CFP) with multiple enzymatic activities, serving as bioreactors responsive TME cues, were synthesized typical solvothermal method for augmented sonodynamic therapy (SDT) chemodynamic (CDT) elicitation of robust immune response. The CFP occupying...
MR imaging-guided a synergistic ferroptosis-photodynamic therapy strategy can enhance antitumor effects by accumulating intracellular ROS through the utilization of iron-based nanoparticles.
Overcoming adverse effects and selectively delivering drug to target cells are two major challenges in the treatment of ulcerative colitis (UC). Lysine-proline-valine (KPV), a naturally occurring tripeptide, has been shown attenuate inflammatory responses colonic cells. Here, we loaded KPV into hyaluronic acid (HA)-functionalized polymeric nanoparticles (NPs). The resultant HA-KPV-NPs had desirable particle size (∼272.3 nm) slightly negative zeta potential (∼-5.3 mV). These NPs successfully...
A myriad of drug delivery systems such as liposomes, micelles, polymers and inorganic nanoparticles (NPs) have been developed for cancer therapy. Very few them, however, the ability to integrate multiple functionalities specific delivery, high circulation stability, controllable release good biocompatibility biodegradability in a single system improve therapeutic efficacy. Herein, we report two types stimuli-responsive nonporous silica prodrug NPs towards this goal controlled anticancer...
Indocyanine green (ICG) is capable of inducing a photothermal effect and the production cytotoxic reactive oxygen species for cancer therapy. However, major challenge in applying ICG molecules antitumor therapy associated with their instability aqueous conditions rapid clearance from blood circulation, which causes insufficient bioavailability at tumor site. Herein, we conjugated Prussian blue nanoparticles enclosing Fe3O4 nanocore, was facilitated by cationic polyethyleneimine via...
Amphiphilic star-like block copolymers form robust biocompatible unimolecular micelles that are efficient in the delivery of anticancer drugs such as doxorubicin.
Abstract Tumor hypoxia severely impedes the therapeutic efficacy of type II photodynamic therapy (PDT) depending on singlet oxygen ( 1 O 2 ) generation. To combat hypoxic tumors, herein, a new approach is devised to boost superoxide radical (O •− photogeneration for I PDT. Heavy atoms are introduced onto aza‐BODIPY molecules (iodine substituted butoxy‐aza‐BODIPY, IBAB) promote their intersystem‐crossing (ISC) ability. Meanwhile, methoxy‐poly(ethylene glycol)‐ b ‐poly(2‐(diisopropylamino)...
Poly(dimethylsiloxane) (PDMS) has been widely utilized in micro-electromechanical systems (MEMS) and implantable devices. To improve the hemocompatibility of a PDMS-based implant, facile technique was developed by modifying PDMS with hyaluronic acid (HA) polydopamine (PDA) composite (HA/PDA). Under appropriate ratio HA to PDA, platelet adhesion activation were considerably reduced on modified substrates, indicating an enhanced compared native or those coated PDA solely. HA/PDA coating also...
Environmental stimuli, including pH, light, and temperature, have been utilized for activating controlled drug delivery to achieve efficient antitumor therapeutics while minimizing undesirable side effects. In this study, a multifunctional nanoplatform based on hollow mesoporous copper sulfide nanoparticles (H-CuS NPs) was developed by loading the interior cavity of NPs with drug-loaded phase-change material (PCM, 1-tetradecanol). Doxorubicin (DOX) chlorin e6 (Ce6) were selected as model...
The combination of chemotherapy and immunotherapy motivates a potent immune system by triggering immunogenic cell death (ICD), showing great potential in inhibiting tumor growth improving the immunosuppressive microenvironment (ITM). However, therapeutic effectiveness has been restricted inferior drug bioavailability. Herein, we reported universal bioresponsive doxorubicin (DOX)-based nanogel to achieve tumor-specific co-delivery drugs. DOX-based mannose nanogels (DM NGs) was designed...
Recent advances in the use of nonporous silica nanoparticles as theranostic platforms for various biomedical applications, particularly drug delivery, bioimaging and bio-adhesives.
Abstract Nanoparticle‐based tumor immunotherapy has emerged to show great potential for simultaneously regulating the immunosuppressive microenvironment, reducing unpleasant side effects, and activating immunity. Herein, an excipient‐free glutathione/pH dual‐responsive prodrug nanoplatform is reported immunotherapy, simply by sequentially liberating 5‐aminolevulinic acid immunogenically inducing doxorubicin drug molecules, which can leverage acidity reverse microenvironment. The obtained...
Polymeric microneedles have attracted increasing attention as a minimally invasive platform for delivering drugs or vaccines in more patient-friendly manner. However, traditional microfabrication techniques using negative molds with needle-shaped cavities usually require cumbersome centrifugation and vacuum degassing processes, which restricted the scaled-up mass production of polymeric microneedles. Herein, novel polydimethylsiloxane (PDMS)-based mold packed silk fibroin scaffold is...
Regenerated silk fibroin (SF) is a type of natural biomacromolecules with outstanding biocompatibility and biodegradability. However, stimulus-responsive SF-based nanocomplex has seldom been reported for application in tumor diagnosis therapy. Methods: As proof-of-concept study, multifunctional SF@MnO2 nanoparticle-based platform was strategically synthesized using SF as reductant template via biomineralization-inspired crystallization process an extremely facile way. Because their...
To date, the construction of heterogeneous interfaces between sonosensitizers and other semiconductors or noble metals has aroused increasing attention, owing to an enhanced interface charge transfer, augmented spin–flip, attenuated activation energy oxygen. Here, a smart therapeutic nanoplatform is constructed by surface immobilization glucose oxidase (GOx) onto TiO2@Pt Schottky junction. The sonodynamic therapy (SDT) starvation (ST) mediated TiO2@Pt/GOx (TPG) promote systemic tumor...
Immune checkpoint blockade (ICB) therapy shows excellent efficacy against malignancies; however, insufficient tumor immunogenicity and the immunosuppressive microenvironment (TME) are considered as two major stumbling blocks to a broad ICB response. Here, combinational therapeutic strategy is reported, wherein TME-reactive oxygen species/pH dual-responsive signal transducers activators of transcription 3 inhibitor nanoprodrugs MPNPs combined with oncolytic herpes simplex virus 1 virotherapy...
Polymer systems can be designed into different structures and morphologies according to their physical chemical performance requirements, are considered as one of the most promising controlled delivery that effectively improve cancer therapeutic index. However, majority polymer simple spherical nanostructures. To explore morphology/size-oriented optimization, here, we synthesized three novel cylindrical brushes (CPBs) by atom transfer radical polymerization (ATRP), which were...