A5084633809- Advanced biosensing and bioanalysis techniques
- Genomics, phytochemicals, and oxidative stress
- Biosensors and Analytical Detection
- Heme Oxygenase-1 and Carbon Monoxide
- RNA Interference and Gene Delivery
- Nanoparticles: synthesis and applications
- Nanoparticle-Based Drug Delivery
- Autophagy in Disease and Therapy
- Ferroptosis and cancer prognosis
- Gold and Silver Nanoparticles Synthesis and Applications
- Inflammasome and immune disorders
- Nanoplatforms for cancer theranostics
- Vitamin C and Antioxidants Research
- Carcinogens and Genotoxicity Assessment
- Drug-Induced Hepatotoxicity and Protection
- Microplastics and Plastic Pollution
- Graphene and Nanomaterials Applications
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Extracellular vesicles in disease
- Immune Response and Inflammation
- Toxic Organic Pollutants Impact
- Air Quality and Health Impacts
- MicroRNA in disease regulation
- Advanced Glycation End Products research
- Advanced Nanomaterials in Catalysis
Southwest University
2016-2025
Pharmaceutical Biotechnology (Czechia)
2018-2021
Molecular Sensing (United States)
2021
Inha University Hospital
2016
Jilin University
2013
Interface (United States)
2012-2013
University of Florida
2012-2013
University of Florida Health
2012-2013
Hunan University
2013
First Hospital of Jilin University
2013
Nanotechnology has allowed the construction of various nanostructures for applications, including biomedicine. However, a simple target-specific, economical, and biocompatible drug delivery platform with high maximum tolerated doses is still in demand. Here, we report aptamer-tethered DNA nanotrains (aptNTrs) as carriers targeted transport cancer therapy. Long aptNTrs were self-assembled from only two short upon initiation by modified aptamers, which worked like locomotives guiding toward...
An aptamer switch probe (ASP) linking chlorin e6 (Ce6), a photosensitizer molecule, to the surface of gold nanorods (AuNRs) was used target cancer cells for photodynamic therapy (PDT) and photothermal (PTT). In presence cells, ASP changes conformation drive Ce6 away from surface, thereby producing singlet oxygen PDT upon light irradiation. Since each AuNR is modified with many ASP-Ce6 molecules, AuNR-ASP-Ce6 conjugate yields enhanced binding therapeutic effect by added ability carry...
MR imaging-guided a synergistic ferroptosis-photodynamic therapy strategy can enhance antitumor effects by accumulating intracellular ROS through the utilization of iron-based nanoparticles.
The massive production of plastics causes the ubiquitous existence microplastics (MPs) in biota, therefore, posing exposure risks and potential health concerns to human beings. However, exact mechanisms MPs-induced toxicities abnormalities are largely unknown. In this study, we developed a mouse model gavage polystyrene (PS MPs) for 30 days. We found that PS MPs can damage intestinal barrier, accumulate liver tissue, cause injury. intestine both highly associated with bile acid (BA)...
Fluorescent-magnetic-biotargeting multifunctional nanobioprobes (FMBMNs) have attracted great attention in recent years due to their increasing, important applications biomedical research, clinical diagnosis, and biomedicine. We previously developed such for the detection isolation of a single kind tumor cells. Detection multiple markers or cells from complex samples sensitively with high efficiency is critical early diagnosis tumors, especially malignant tumors cancers, which will improve...
The development of nanomaterials that combine diagnostic and therapeutic functions within a single nanoplatform is extremely important for molecular medicine. Molecular imaging with simultaneous diagnosis therapy will provide the multimodality needed accurate targeted therapy. Here, we demonstrate gold-coated iron oxide (Fe3O4@Au) nanoroses five distinct functions, which integrate aptamer-based targeting, magnetic resonance (MRI), optical imaging, photothermal chemotherapy into one probe....
A novel nanohybrid of hyaluronic acid (HA)-decorated graphene oxide (GO) was fabricated as a targeted and pH-responsive drug delivery system for controlling the release anticancer doxorubicin (DOX) tumor therapy. For preparation, DOX first loaded onto GO nanocarriers via π-π stacking hydrogen-bonding interactions, then it decorated with HA to produce HA-GO-DOX nanohybrids H-bonding interactions. In this strategy, served both targeting moiety hydrophilic group, making as-prepared targeting,...
Food poisoning and infectious diseases caused by pathogenic bacteria such as Staphylococcus aureus (SA) are serious public health concerns. A method of specific, sensitive, rapid detection is essential important. This study presents a strategy that combines aptamer antibiotic-based dual recognition units with magnetic enrichment fluorescent to achieve specific sensitive quantification SA in authentic specimens the presence much higher concentrations other bacteria. Aptamer-coated beads...
The effective monitoring, identification, and quantification of pathogenic bacteria is essential for addressing serious public health issues. In this study, we present a universal facile one-step strategy sensitive selective detection using dual-molecular affinity-based Förster (fluorescence) resonance energy transfer (FRET) platform based on the recognition bacterial cell walls by antibiotic aptamer molecules, respectively. As proof concept, Vancomycin (Van) nucleic acid were employed in...
DNA nanotrain: Anchoring of preformed fluorescent nanodevices (NDs; see picture) and in situ self-assembly NDs on target living cell surfaces are reported. The the nanodevice was further shown cells mixtures. These exhibited fluorescence emission underwent resonance energy transfer (FRET) surfaces. As a service to our authors readers, this journal provides supporting information supplied by authors. Such materials peer reviewed may be re-organized for online delivery, but not copy-edited or...
The adverse biological and ecological consequences of plastic debris have become a serious problem worldwide. Evidences uncovered the accumulation nanoplastics (NPs) in organisms. In complex environment, proteins are prone to adsorbed onto NPs' surface form protein corona layer, which mediates interaction NPs with cells. Here, we discovered polystyrene (PS) fetal bovine serum (FBS) altered cytotoxic effects. Mechanistically, prefabricated FBS mediated relief autophagic flux blockage,...
Abstract Exposure to nanomaterials (NMs) is an emerging threat human health, and the understanding of their intracellular behavior related toxic effects urgently needed. Ferroptosis a newly discovered, iron-mediated cell death that distinctive from apoptosis or other cell-death pathways. No evidence currently exists for effect “iron free” engineered NMs on ferroptosis. We showed by several approaches (1) zinc oxide nanoparticles (ZnO NPs)-induced involves ferroptosis; (2) ZnO NPs-triggered...
Developing a specific, sensitive, rapid, and on-site method for detecting pathogenic bacteria in food samples is critical to ensuring public safety. This article demonstrates CRISPR/Cas13a system chemiluminescence resonance energy transfer (CRET) (CRISPR/Cas 13a-assisted CRET)-based strategy sensitive detection of real samples. Once the hybrid double strand aptamerS. aureus-cRNA recognizes target model Staphylococcus aureus (S. aureus), released cRNA would bind with CRISPR/Cas 13a form...
Based on their enhanced cellular uptake, stability, biocompatibility, and versatile surface functionalization, spherical nucleic acids (SNAs) have become a potentially useful platform in biological applications. It still remains important to expand the SNAs' "toolbox", especially given current interest multimodal or theranostic nanomaterials, that is, composites capable of multiple simultaneous applications such as imaging, sensing, drug delivery. In this paper, we engineered...