A5007542274- Asymmetric Synthesis and Catalysis
- Synthesis and Catalytic Reactions
- Heme Oxygenase-1 and Carbon Monoxide
- Chemical Synthesis and Analysis
- Sulfur-Based Synthesis Techniques
- Microplastics and Plastic Pollution
- Organophosphorus compounds synthesis
- Inflammasome and immune disorders
- Synthesis and Reactions of Organic Compounds
- Organic and Inorganic Chemical Reactions
- Nanoparticles: synthesis and applications
- Cytokine Signaling Pathways and Interactions
- Microbial infections and disease research
- Radical Photochemical Reactions
- Organoselenium and organotellurium chemistry
- Adipokines, Inflammation, and Metabolic Diseases
- Estrogen and related hormone effects
- Antibiotic Resistance in Bacteria
- Fluorine in Organic Chemistry
- Extracellular vesicles in disease
- Fungal Plant Pathogen Control
- Advanced Glycation End Products research
- Immune cells in cancer
- Synthesis of β-Lactam Compounds
- Nanoparticle-Based Drug Delivery
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Guang’anmen Hospital
2025
Research Center for Eco-Environmental Sciences
2022-2024
Chinese Academy of Sciences
2004-2024
Southwest University
2018-2024
Bristol-Myers Squibb (United States)
2006-2017
Bristol-Myers Squibb (Germany)
2009-2011
South China Botanical Garden
2008
Xi'an Jiaotong University
2007
University of Arkansas for Medical Sciences
2007
The massive production of plastics causes the ubiquitous existence microplastics (MPs) in biota, therefore, posing exposure risks and potential health concerns to human beings. However, exact mechanisms MPs-induced toxicities abnormalities are largely unknown. In this study, we developed a mouse model gavage polystyrene (PS MPs) for 30 days. We found that PS MPs can damage intestinal barrier, accumulate liver tissue, cause injury. intestine both highly associated with bile acid (BA)...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTImproved methodology for photocyclization reactionsLongbin Liu, Bingwei Yang, Thomas J. Katz, and Michael K. PoindexterCite this: Org. Chem. 1991, 56, 12, 3769–3775Publication Date (Print):June 1, 1991Publication History Published online1 May 2002Published inissue 1 June 1991https://pubs.acs.org/doi/10.1021/jo00012a005https://doi.org/10.1021/jo00012a005research-articleACS PublicationsRequest reuse permissionsArticle...
Searching through a collection of 124 Staphylococcus aureus clinical strains, we found one isolate, strain 01A1032, that inactivates 14- and 16-membered macrolides. The products inactivation were purified from supernatant fluids cultures exposed to erythromycin for 3 h be identical Escherichia coli strains encode either an EreA or EreB esterase. Further, 01A1032 was shown resistant azithromycin, 15-membered macrolide, by alternate mechanism, efflux. Thus, harbors determinants encoding...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAn unusual oxidative cyclization. A synthesis and absolute stereochemical assignment of (-)-rocaglamideBarry M. Trost, Paul D. Greenspan, Bingwei V. Yang, Mark G. SaulnierCite this: J. Am. Chem. Soc. 1990, 112, 24, 9022–9024Publication Date (Print):November 1, 1990Publication History Published online1 May 2002Published inissue 1 November 1990https://doi.org/10.1021/ja00180a081RIGHTS & PERMISSIONSArticle Views1475Altmetric-Citations82LEARN ABOUT...
Polychlorinated biphenyls (PCBs) are one of the most refractory environmental pollutants. Because their ubiquitous existence in biological systems (including human body), it is important to investigate toxic behavior. Our previous findings demonstrated that a high reactive metabolite PCB, namely PCB29-pQ, causes several programmed cell death (PCD) such as intrinsic/extrinsic apoptosis and autophagic death. The mechanistic study suggested actions PCB29-pQ largely related its oxygen species...
A mild and efficient procedure is described for the N-debenzylation of tertiary amines using α-chloroethyl chloroformate. The scope selectivity are also discussed.
The biological activities of nanoparticles (NPs), which include endocytosis by macrophages and subsequent intracellular degradation and/or release, transfer to other cells, or translocation across tissue barriers, highly depend on their fate in living organisms. Yet, especially the distal "barrier-crossing" trafficking NPs, is still unclear. exosome (Exo) plays a crucial role intercellular communication barrier trafficking. Here, we report that ZnCdSe@ZnS quantum dots (QDs), as...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectron delocalization in helical quinone anion radicalsBingwei Yang, Longbin Liu, Thomas J. Katz, Charles A. Liberko, and Larry L. MillerCite this: Am. Chem. Soc. 1991, 113, 23, 8993–8994Publication Date (Print):November 1, 1991Publication History Published online1 May 2002Published inissue 1 November 1991https://pubs.acs.org/doi/10.1021/ja00023a084https://doi.org/10.1021/ja00023a084research-articleACS PublicationsRequest reuse permissionsArticle...
A series of 2,2-dimethyl-3,3-diphenyl-propanamides as novel glucocorticoid receptor modulators is reported. SAR exploration led to the identification 4-hydroxyphenyl propanamide derivatives displaying good agonist activity in GR-mediated transrepression assays and reduced transactivation assays. Compounds 17 30 showed anti-inflammatory comparable prednisolone rat carrageenan-induced paw edema model, with markedly decreased side effects regard increases blood glucose expression hepatic...
Background: Miscellaneous cardiovascular risk factors have been defined, but the contribution of environmental pollutants exposure on disease (CVD) remains underappreciated. Objective: We investigated potential impact typical pollutant atherogenesis and its underlying mechanisms. Methods: used human umbilical vein endothelial cells (HUVECs) apolipoprotein E knockout (ApoE−/−) mice to investigate how 2,3,5-trichloro-6-phenyl-[1,4]-benzoquinone (PCB29-pQ, a toxic polychlorinated biphenyl...
The reentry circuit of idiopathic left ventricular tachycardia (ILVT) has been demonstrated to be confined the posterior Purkinje network. We hypothesized that mapping and linear ablation fascicle (LPF) during sinus rhythm guided by non-contact can effectively modify arrhythmogenic substrate in patients with ILVT abolish tachycardia.Six ILVT, consisting one case which conventional failed three times, recurrent case, non-inducible common cases, were included study. After a three-dimensional...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAsymmetric induction in a palladium-catalyzed TMM cycloaddition. Mechanistic implications regarding the reactive intermediateBarry M. Trost, Bingwei Yang, and Maria L. MillerCite this: J. Am. Chem. Soc. 1989, 111, 16, 6482–6484Publication Date (Print):August 1, 1989Publication History Published online1 May 2002Published inissue 1 August 1989https://pubs.acs.org/doi/10.1021/ja00198a102https://doi.org/10.1021/ja00198a102research-articleACS...