A5100714797- COVID-19 and healthcare impacts
- COVID-19 Clinical Research Studies
- Advanced biosensing and bioanalysis techniques
- Synthesis and biological activity
- Cancer-related molecular mechanisms research
- Advanced Data and IoT Technologies
- Metal complexes synthesis and properties
- Advanced battery technologies research
- Immune cells in cancer
- Cancer therapeutics and mechanisms
- Biosensors and Analytical Detection
- Stochastic processes and financial applications
- Liver Disease Diagnosis and Treatment
- Insurance, Mortality, Demography, Risk Management
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- SARS-CoV-2 and COVID-19 Research
- Cancer Mechanisms and Therapy
- Electrochemical Analysis and Applications
- Thermal Radiation and Cooling Technologies
- Supercapacitor Materials and Fabrication
- Luminescence and Fluorescent Materials
- Quinazolinone synthesis and applications
- MicroRNA in disease regulation
- Respiratory Support and Mechanisms
Shihezi University
2023-2025
Zhejiang Environmental Monitoring Center
2023-2025
Hubei University of Medicine
2019-2025
Taihe Hospital
2019-2025
Yangzhou University
2020-2025
Nankai University
2020-2025
Jianghan University
2025
First Affiliated Hospital of Henan University
2024-2025
Huazhong University of Science and Technology
2012-2024
Soil and Fertilizer Institute of Hunan Province
2024
The <italic>in situ</italic> formed AgZn<sub>3</sub> alloy on the Zn@Ag anode can facilitate uniform zinc deposition and enhance electrochemical performance of ZIBs.
Abstract Successful oral insulin administration can considerably enhance the quality of life (QOL) diabetes patients who must frequently take injections. Oral administration, on other hand, is seriously hampered by gastrointestinal enzymes, wide pH range, mucus and mucosal layers, which limit bioavailability to ≤ 2%. Therefore, a large number technological solutions have been proposed increase insulin, in polymeric nanoparticles (PNPs) are highly promising for delivery. The recently...
High-flow nasal cannula (HFNC) oxygen therapy is being increasingly used to prevent post-extubation hypoxemic respiratory failure and reintubation. However, evidence support the use of HFNC in chronic obstructive pulmonary disease (COPD) patients with hypercapnic after extubation limited. This study was conducted test if non-inferior non-invasive ventilation (NIV) preventing treatment COPD previously intubated for failure.COPD who were already receiving invasive randomized or NIV at two...
Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the ongoing global pandemic that poses substantial challenges to public health worldwide. A subset of COVID-19 patients experience systemic inflammatory response, known as cytokine storm, which may lead death. Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) an important mediator inflammation and cell Here, we examined interaction RIPK1-mediated innate...
Highlights•Molecularly defined and functionally distinct D28K+ D28K− subnetworks•D28K+ subnetworks differ in morphological physiological properties•D28K+ → VPNs cholinergic subnetwork controls anxiety-like behaviors via Kcnh1•D28K− DGNs encodes spatial memory Cacna1hSummaryCholinergic neurons the medial septum (MS) constitute a major source of input to forebrain modulate diverse functions, including sensory processing, memory, attention. Most studies date have treated as single population;...
Since the Simplified Molecular Input Line Entry System (SMILES) is oriented to atomic-level representation of molecules and not friendly in terms human readability editable, however, IUPAC closest natural language very human-oriented performing molecular editing, we can manipulate generate corresponding new produce programming-friendly forms SMILES. In addition, antiviral drug design, especially analogue-based also more appropriate edit design directly from functional group level than atomic...
Low molecular weight (6.5 kDa) Glycyrrhiza polysaccharide (GP) exhibits good immunomodulatory activity, however, the mechanism underlying GP-mediated regulation of immunity and gut microbiota remains unclear. In this study, we aimed to reveal mechanisms using cyclophosphamide (CTX)-induced immunosuppressed intestinal mucosal injury models. GP reversed CTX-induced structural damage increased number goblet cells, CD4+, CD8+ T lymphocytes, mucin content, particularly by maintaining balance...
Abstract Background Although cumulative studies have demonstrated a beneficial effect of high-flow nasal cannula oxygen (HFNC) in acute hypercapnic respiratory failure, randomized trials to compare HFNC with non-invasive ventilation (NIV) as initial treatment exacerbations chronic obstructive pulmonary disease (AECOPD) patients acute-moderate failure are limited. The aim this randomized, open label, non-inferiority trial was rates between and NIV such patients. Methods Patients diagnosed...
Acute myocardial infarction (AMI) is often present in old populations and rare young people. Its incidence significantly increased recent years. The mechanism disease course of AMI people are probably different from that population. aim this study was to analyze clinical risk factors STEMI patients. Data collected consecutive patients ≤ 44 years age (young; n = 86) 60–74 (old; 65) diagnosed with STEMI, 79 age-matched without coronary artery (CAD), hospitalized between January 2009 June 2013....
Abstract Recently mapped transcriptomic landscapes reveal the extent of heterogeneity in cancer‐associated fibroblasts (CAFs) beyond previously established single‐gene markers. Functional analyses individual CAF subsets within tumor microenvironment are critical to develop more accurate CAF‐targeting therapeutic strategies. However, there is a lack robust preclinical models that reflect this vitro. In study, single‐cell RNA sequencing datasets acquired from head and neck squamous cell...
Plasma amyloid-β (Aβ), phosphorylated tau-181 (p-tau181), neurofilament light (NfL) and glial fibrillary acidic protein (GFAP) potentially aid in the diagnosis of neurodegenerative dementias. We aim to conduct a comprehensive comparison between different biomarkers their combination, which is lacking, multicenter Chinese dementia cohort consisting Alzheimer's disease (AD), frontotemporal (FTD), progressive supranuclear palsy (PSP). enrolled 92 demented patients [64 AD, 16 FTD, 12 PSP with...
Aberrant microRNA (miRNA) expression contributes to a series of malignant cancer behaviors, including radioresistance. Our previous study showed differential miR-185-3p in post-radiation nasopharyngeal carcinoma (NPC) cells. To investigate the role NPC radioresistance, CNE-2 and 5-8F cells were transfected with mimic inhibitor, respectively. CCK-8 assay colony formation experiment confirmed that affected radioresistance A negative correlation between WNT2B was observed tissues. Luciferase...
Radioresistance is one of the major factors limiting therapeutic efficacy and prognosis patients with nasopharyngeal carcinoma (NPC). Accumulating evidence has suggested that aberrant expression long noncoding RNAs (lncRNAs) contributes to cancer progression. Therefore, here we identified lncRNAs associated radioresistance in NPC. The differential profiles NPC were constructed by next-generation deep sequencing comparing radioresistant cells their parental cells. LncRNA-related mRNAs...