A5034211225- Glioma Diagnosis and Treatment
- Glass properties and applications
- Cancer Genomics and Diagnostics
- Solid State Laser Technologies
- RNA modifications and cancer
- Luminescence Properties of Advanced Materials
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Organ Transplantation Techniques and Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Nuclear Structure and Function
- Cancer-related molecular mechanisms research
- Neuroinflammation and Neurodegeneration Mechanisms
- Phase-change materials and chalcogenides
- Immune Cell Function and Interaction
- Cancer Mechanisms and Therapy
- COVID-19 Clinical Research Studies
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Photonic Crystal and Fiber Optics
- Long-Term Effects of COVID-19
- Ubiquitin and proteasome pathways
- Cancer Immunotherapy and Biomarkers
- Berberine and alkaloids research
- Lung Cancer Research Studies
Sun Yat-sen University
2013-2025
Southwest Hospital
2019-2025
Army Medical University
2019-2025
Chengdu University
2025
Shanghai Ninth People's Hospital
2024-2025
Shanghai Jiao Tong University
2024-2025
Peking University Shenzhen Hospital
2025
Second Affiliated Hospital of Nanchang University
2025
Nanchang University
2021-2025
Guangxi Medical University
2022-2025
One of the most fundamental questions in biology is what types cells form different tissues and organs a functionally coordinated fashion. Larger-scale single-cell sequencing experiment studies are now rapidly opening up new ways to track this question by revealing substantial cell markers for distinguishing tissues. Here, we developed CellMarker database (http://biocc.hrbmu.edu.cn/CellMarker/ or http://bio-bigdata.hrbmu.edu.cn/CellMarker/), aiming provide comprehensive accurate resource...
High functional heterogeneity of cancer cells poses a major challenge for research. Single-cell sequencing technology provides an unprecedented opportunity to decipher diverse states at single-cell resolution, and scRNA-seq datasets have been largely accumulated. This emphasizes the urgent need build dedicated resource decode single cells. Here, we developed CancerSEA (http://biocc.hrbmu.edu.cn/CancerSEA/ or http://202.97.205.69/CancerSEA/), first database that aims comprehensively explore...
Abstract Severe COVID-19 disease caused by SARS-CoV-2 is frequently accompanied dysfunction of the lungs and extrapulmonary organs. However, organotropism port virus entry for systemic dissemination remain largely unknown. We profiled 26 autopsy cases from four cohorts in Wuhan, China, determined distribution SARS-CoV-2. was detected multiple organs critically ill patients up to 67 days after symptom onset. Based on pathological features patients, divided into viral intrapulmonary subtypes....
Er 3+ doped Nb2O5–TeO2 (NT) glass suitable for developing optical fiber laser and amplifier has been fabricated characterized. Intense broad 1.53 μm infrared fluorescence visible upconversion luminescence were observed under 975 nm diode 798 excitation. For emission band, the full width at half-maximum is 51 nm, lifetime 2.6 ms, quantum efficiency ∼100%. The maximum cross section 8.52×10−21 cm2 1.532 μm, higher than values in silicon phosphate glasses. Under excitation, efficient 531, 553,...
Systematic studies of cooperative upconversion and Yb3+–Er3+ energy transfer in newly developed phosphate glasses were performed by a rate-equation formalism. The cooperative-upconversion coefficients the 4I13/2 level for different Er3+ concentrations determined from luminescence-decay curves high pump intensities. A small coefficient 1.1×10-18 cm3/s was obtained concentration 4×1020 ions/cm3.Yb3+–Er3+ energy-transfer an 2×1020 ions/cm3 codoped with Yb3+ calculated lifetime measurements...
Hepatitis B virus X (HBx) protein is implicated in hepatitis (HBV)–associated liver carcinogenesis. However, it remains unclear whether HBx–expressing hepatic progenitor cells (HPCs) are attributed to tumor formation. In this study, by using HBx transgenic mice and a 3,5–diethoxycarbonyl–1,4–dihydrocollidine (DDC)–induced injury model, the relationship between expression tumorigenicity of HPCs was analyzed. Compared with control mice, an elevated number EpCAM+ characteristics observed after...
Although autophagy is most critical for survival of cancer cells, especially in fast-growing tumors, the mechanism remains to be fully characterized. Herein we report that PSMD10/gankyrin promotes hepatocellular carcinoma (HCC) response starvation or stress through 2 complementary routes. PSMD10 was physically associated with ATG7 cytoplasm, and this association enhanced by initial nutrient deprivation. Subsequently, translocated into nucleus bound cooperatively nuclear HSF1 (heat shock...
Severe neurological symptoms are associated with Coronavirus disease 2019 (COVID-19). However, the morphologic features, pathological nature and their potential mechanisms in patient brains have not been revealed despite evidence of neurotropic infection. In this study, neuropathological damages infiltrating inflammatory cells were quantitatively evaluated by immunohistochemical staining, ultrastructural examination under electron microscopy, an image threshold method, postmortem from nine...
The overall survival of patients with hepatocellular carcinoma (HCC) remains poor, and the molecular mechanisms underlying HCC progression aggressiveness are unclear. Here, we report that increased expression p28GANK (Gankyrin, PSMD10, or p28) in human predicts poor disease recurrence after surgery. Patients who have large tumors, vascular invasion intrahepatic distant metastasis, expressed high levels p28GANK. Invasive tumors overexpressing were featured by active epithelial-mesenchymal...
Increasing evidence shows that oxidative stress and the hyperphosphorylation of tau protein play essential roles in progression Alzheimer's disease (AD). Quercetin is a major flavonoid has anti-oxidant, anti-cancer anti-inflammatory properties. We investigated neuroprotective effects quercetin to HT22 cells (a cell line from mouse hippocampal neurons). found Okadaic acid (OA) induced at Ser199, Ser396, Thr205, Thr231 produced cells. The suppressed viability decreased levels lactate...
Systematic autopsy and comprehensive pathological analyses of COVID-19 decedents should provide insights into the disease characteristics facilitate development novel therapeutics. In this study, we report findings from lungs lymphatic organs 12 decedents-findings that evaluated histopathological changes, immune cell signature inflammatory factor expression in lungs, spleen lymph nodes. Here show major pulmonary alterations included diffuse alveolar damage, interstitial fibrosis exudative...
The aim of this study is to clarify the clinical implication and functional role structure specific recognition protein 1 (SSRP1) in hepatocellular carcinoma (HCC) explore underlying mechanism aberrant high expression SSRP1 cancers. In present investigation, we validated that was upregulated HCC samples. We also demonstrated its upregulation associated with several clinicopathologic features such as higher serum AFP level, larger tumor size, T stage patients; indicated shorter overall...
Tumor mutational burden (TMB) is a potential biomarker for immune checkpoint therapy and prognosis. The impact of TMB on clinical outcomes the correlation coefficient between exome sequencing targeted in glioma have not yet been explored.Somatic mutations coding regions 897 primary gliomas RNA-seq data 654 patients Cancer Genome Atlas (TCGA) database were analyzed as training set, while another 286 Chinese Glioma (CGGA) used validation. Descriptive correlational analyses conducted with TMB....
Abstract Ischemia–reperfusion injury (IRI) remains the major reason for impaired donor graft function and increased mortality post-liver transplantation. The mechanism of IRI involves multiple pathophysiological processes numerous types cells. However, a systematic comprehensive single-cell transcriptional profile intrahepatic cells during liver transplantation is still unclear. We performed transcriptome analysis 14,313 from tissues collected pre-procurement, at end preservation 2 h...
In recent years, nanoplastics (NPs) and triclosan (TCS, a pharmaceutical personal care product) have emerged as environmental pollution issues, their combined presence has raised widespread concern regarding potential risks to organisms. However, the toxicity mechanisms of NPs TCS remain unclear. this study, we investigated toxic effects polystyrene on KGN cells, human ovarian granulosa cell line. We exposed cells (150 μg/mL) (15 μM) alone or together for 24 hours. Co-exposure significantly...
Hepatocellular carcinoma (HCC) is a prototype of inflammation‐associated cancer. Oncoprotein Gankyrin, which mostly increases in HCC, plays critical role HCC development and metastasis. However, the exact mechanism Gankyrin up‐regulation remains unclear. A luciferase reporter was developed to screen potential regulator for from list proinflammatory cytokines, interleukin (IL)‐1β found as one its activators. In clinical premalignant malignant liver disease samples, enhanced...
Systematic sequencing of cancer genomes has revealed prevalent heterogeneity, with patients harboring various combinatorial patterns genetic alteration. In particular, a phenomenon that group genes exhibits mutually exclusive been widespread across cancers, covering broad spectrum crucial pathways. Recently, there is considerable evidence showing that, mutual exclusivity reflects alternative functions in tumor initiation and progression, or suggests adverse effects their concurrence. Given...
Abstract Alzheimer’s disease (AD) is a complex disorder influenced by both genetic and environmental components has become major public health issue throughout the world. Oxidative stress inflammation play important roles in evolution of those pathological symptoms. Jatrorrhizine (JAT), main component traditional Chinese herbal, coptidis rhizome, been shown to have neuroprotective effects we previously showed that it also able clear oxygen free radicals reduce inflammatory responses. In this...
Over the past decade, thousands of long noncoding RNAs (lncRNAs) have been identified, many which play crucial roles in normal physiology and human disease. LncRNAs can interact with chromatin then recruit protein complexes to remodel states, thus regulating gene expression. However, how lncRNA-chromatin interactions contribute their biological functions is largely unknown. Here, we collected constructed an atlas 188,647 mouse. All lncRNAs showed diverse epigenetic modification patterns at...