A5101978412- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Pelvic and Acetabular Injuries
- Cervical and Thoracic Myelopathy
- Psoriasis: Treatment and Pathogenesis
- Ginkgo biloba and Cashew Applications
- Musculoskeletal pain and rehabilitation
- Neurological Disease Mechanisms and Treatments
- Cytokine Signaling Pathways and Interactions
- Dermatology and Skin Diseases
- Immune Response and Inflammation
- Sleep and related disorders
- Ginseng Biological Effects and Applications
- Sleep and Wakefulness Research
- Rheumatoid Arthritis Research and Therapies
- Circadian rhythm and melatonin
- Spinal Cord Injury Research
- Healthcare and Venom Research
- Oral and Maxillofacial Pathology
- NF-κB Signaling Pathways
- T-cell and B-cell Immunology
- Traumatic Brain Injury and Neurovascular Disturbances
- Spinal Hematomas and Complications
- Autophagy in Disease and Therapy
- Gut microbiota and health
South China Agricultural University
2025
Nanfang Hospital
2021-2025
Nanfang College Guangzhou
2025
The First Affiliated Hospital, Sun Yat-sen University
2025
Sun Yat-sen University
2025
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2016-2024
Wenzhou Medical University
2014-2024
Fujian University of Traditional Chinese Medicine
2021-2024
Yunnan University
2024
University of Houston
2007-2023
Increasing evidence suggests that the presence of endotoxemia is substantial clinical relevance to patients with cirrhosis, but it unclear whether and how gut-derived LPS amplifies tumorigenic response liver. We found circulating levels were elevated in animal models carcinogen-induced hepatocarcinogenesis. Reduction using antibiotics regimen rats or genetic ablation its receptor Toll-like 4 (TLR4) mice prevented excessive tumor growth multiplicity. Additional investigation revealed TLR4...
Abstract Damaged deoxyribonucleic acid (DNA) is a primary pathologic factor for osteoarthritis (OA); however, the mechanism by which DNA damage drives OA unclear. Previous research demonstrated that cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) participates in response. As result, current study aimed at exploring role STING, major effector cGAS-STING signaling casacde, progress vitro, as well vivo. In this study, expression STING was evaluated human and mouse tissues,...
Hepatitis B virus X (HBx) protein is implicated in hepatitis (HBV)–associated liver carcinogenesis. However, it remains unclear whether HBx–expressing hepatic progenitor cells (HPCs) are attributed to tumor formation. In this study, by using HBx transgenic mice and a 3,5–diethoxycarbonyl–1,4–dihydrocollidine (DDC)–induced injury model, the relationship between expression tumorigenicity of HPCs was analyzed. Compared with control mice, an elevated number EpCAM+ characteristics observed after...
Abstract The aim of our study was to evaluate if Sirt6, a NAD + dependent histone deacetylase, plays protective role in cartilage degeneration by suppressing cellular senescence and inflammatory responses. expression level sirt6 normal OA human knee articular compared immunofluorescence western blotting. effect overexpression on replicative chondrocytes NF-κB target genes evaluated. Histological assessment mice joint carried out assess the vivo effects chondrocytes. We found significantly...
Abstract Treatment of intervertebral disc degeneration (IDD) seeks to prevent senescence and death nucleus pulposus (NP) cells. Previous studies have shown that sirt6 exerts potent anti-senescent anti-apoptotic effects in models age-related degenerative disease. However, it is not known whether protects against IDD. Here, we explored influenced The level was reduced senescent human NP Sirt6 overexpression protected apoptosis both replicative stress-induced premature senescence. also...
Oxidative stress-induced apoptosis and senescence of nucleus pulposus (NP) cells play a crucial role in the progression intervertebral disc degeneration (IVDD). Accumulation studies has shown that activated autophagy enhanced autophagic flux can alleviate IVDD. In this study, we explored effects apigenin on IVDD vitro vivo. Apigenin was found to inhibit tert-butyl hydroperoxide (TBHP)-induced apoptosis, senescence, ECM degradation NP cells. addition, treatment restore blockage caused by...
Mycoplasma pneumoniae (MP) is the main culprit of community-acquired pneumonia. Commonly used laboratory testing methods have many shortcomings. Serological diagnosis has low sensitivity, causing false negatives, while a quantitative real-time polymerase chain reaction (qPCR) requires large equipment and professional staff. To make up for these shortcomings, we proposed label-free, low-cost, small-sized ion-sensitive field-effect transistor (ISFET) array based on low-buffered loop-mediated...