A5100658607- Cardiac Imaging and Diagnostics
- Cardiac Structural Anomalies and Repair
- COVID-19 Clinical Research Studies
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Long-Term Effects of COVID-19
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Lipid metabolism and disorders
- Neurological Disease Mechanisms and Treatments
- Healthcare and Venom Research
- Acute Myocardial Infarction Research
- Cardiac Fibrosis and Remodeling
- Cardiac electrophysiology and arrhythmias
- Takotsubo Cardiomyopathy and Associated Phenomena
- Signaling Pathways in Disease
- Cardiac tumors and thrombi
- Traditional Chinese Medicine Studies
- Coronary Interventions and Diagnostics
- Medical Research and Treatments
- Traditional Chinese Medicine Analysis
- Spine and Intervertebral Disc Pathology
- Adipose Tissue and Metabolism
- Gastric Cancer Management and Outcomes
Sun Yat-sen University
2014-2025
Fifth Affiliated Hospital of Sun Yat-sen University
2014-2025
Tianjin Medical University
2025
Tianjin University
2025
University of South China
2019-2024
Haukeland University Hospital
2011-2024
Shanghai Jiao Tong University
2008-2024
Shanghai Sixth People's Hospital
2024
Xi'an Honghui Hospital
2024
Soochow University
2018-2024
Data are lacking whether patients with hypertension who taking angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) have increased severity risk of mortality during hospitalization for coronavirus disease 2019 (COVID-19).
OBJECTIVE Diabetes is one of the most distinct comorbidities COVID-19. Here, we describe clinical characteristics and outcomes in patients with diabetes whom COVID-19 was confirmed or clinically diagnosed (with typical features on lung imaging symptoms) their association glucose-lowering blood pressure–lowering medications. RESEARCH DESIGN AND METHODS In this retrospective study involving 904 (136 diabetes, mostly type 2 diabetes), laboratory were collected compared between group without...
Objective: This study is to evaluate the anti-obese effects of glucosamine (GLC) and chitosan oligosaccharide (COS) on high-fat diet-induced obese rats. Methods: The rats were randomly divided into twelve groups: a normal diet group (NF), (HF), Orlistat group, GLC high-, middle-, low-dose groups (GLC-H, GLC-M, GLC-L), COS1 (COS, number-average molecular weight ≤1000) (COS1-H, COS1-M, COS1-L), COS2 ≤3000) (COS2-H, COS2-M, COS2-L). All received oral treatment by gavage once daily for period...
Abstract Treatment of intervertebral disc degeneration (IDD) seeks to prevent senescence and death nucleus pulposus (NP) cells. Previous studies have shown that sirt6 exerts potent anti-senescent anti-apoptotic effects in models age-related degenerative disease. However, it is not known whether protects against IDD. Here, we explored influenced The level was reduced senescent human NP Sirt6 overexpression protected apoptosis both replicative stress-induced premature senescence. also...
Chimeric antigen receptor-T (CAR-T) cell therapy has shown remarkable success in eradicating hematologic malignancies; however, its efficacy treating solid tumors always been limited due to the presence of an immune-suppressive tumor microenvironment (TME). Here, genetically programmable cellular vesicles expressing high-affinity anti-programmed death-ligand 1 single chain variable fragment (anti-PD-L1 scFv) loaded with glutamine antagonist (D@aPD-L1 NVs) are developed metabolically...
Abstract Treatments for osteoarthritis (OA) are designed to restore chondrocyte function and inhibit cell apoptosis. Previous studies have shown that activation of the glucagon-like peptide-1 receptor (GLP-1R) leads anti-inflammatory anti-apoptotic effects. However, role GLP-1R in pathological process OA is unclear. In present work, we aimed demonstrate potential effect on chondrocytes elucidate its underlying mechanisms. We found with liraglutide could protect against endoplasmic reticulum...
Dysregulated inflammation following myocardial infarction (MI) leads to maladaptive healing and remodeling. The study characterized evaluated a selective formyl peptide receptor 2 (FPR2) agonist BMS-986235 in cellular assays rodents undergoing MI. activated G proteins promoted β-arrestin recruitment, enhanced phagocytosis neutrophil apoptosis, regulated chemotaxis, stimulated interleukin-10 monocyte chemoattractant protein-1 gene expression. Treatment with improved mouse survival, reduced...
Despite investigations into mechanisms linking type 2 diabetes and cancer, there is a gap in knowledge about pharmacotherapy for cancer patients. Epidemiological studies have shown that diabetic patients on different antidiabetic treatments survival. The clinically relevant question whether some pharmacotherapeutic agents promote whereas others inhibit progression. We investigated the hypothesis various drugs had differential direct impact cells using four human cell lines (pancreatic...
C/EBP homologous protein (CHOP) is an important mediator of endoplasmic reticulum (ER) stress-induced cell and organ injury. Here we show that lipopolysaccharide (LPS)-induced acute kidney injury (AKI) associated with ER stress elevated CHOP. We postulated CHOP(-/-) mice would be protected against LPS-induced-AKI. Unexpectedly, while Toll-like receptor 4 (TLR4) expression levels were comparable in kidneys wild-type (WT) mice, developed more severe AKI after LPS injection. Furthermore, the...
Dysregulated inflammation following myocardial infarction (MI) promotes left ventricular (LV) remodeling and loss of function. Targeting resolution by activating formyl peptide receptors (FPRs) may limit adverse progression towards heart failure. This study characterized the cellular signaling properties Compound 43 (Cmpd43), a dual FPR1/FPR2 agonist, examined whether Cmpd43 treatment improves LV infarct in rodent MI models. stimulated FPR1/2-mediated signaling, enhanced proresolution...
Cerebral ischaemia/reperfusion (CI/R) injury is a major challenge due to the lack of effective neuroprotective drugs. Hederagenin (HE) aglycone part saponins extracted from Hedera helix Linné that has exhibited anti-apoptotic and anti-inflammatory effects; however, role HE in CI/R not been elucidated. In this study, mice were intraperitoneally (i.p.) injected with (26.5, 53, or 106 μmol/kg body weight) for 3 days after middle cerebral artery occlusion (MCAO). Neural function brain infarct...
Background and Purpose Hydrogen sulfide (H 2 S) plays important roles as a gasotransmitter in pathologies. Increased expression of the E3 ubiquitin ligase, muscle RING finger‐1 (MuRF1), may be involved diabetic cardiomyopathy. Here we have investigated whether how exogenous H S alleviates cardiac degradation through modifications MuRF1 S‐sulfhydration db/db mice. Experimental Approach Neonatal rat cardiomyocytes were treated with high glucose (40 mM), oleate (100 μM), palmitate (400 NaHS μM)...
Previous studies have found that predicted fat mass and lean body may act differently on adverse events. However, the cardiovascular prognostic value of in patients with type 2 diabetes mellitus (T2DM) has not yet been investigated. We sought to investigate relation between or risk disease T2DM.We conducted a post hoc analysis data from Action Control Cardiovascular Risk Diabetes (ACCORD) study major events T2DM. used sex-specific quartiles index (BMI; kg/m2) (kg/m2). defined event as...
The mechanisms of the improvement glucose homeostasis through angiotensin receptor blockers are not fully elucidated in hypertensive patients. We investigated effects telmisartan on insulin signaling and uptake cultured myotubes skeletal muscle from wild-type muscle-specific peroxisome proliferator-activated (PPAR) δ knockout (MCK-PPARδ(-/-)) mice. Telmisartan increased PPARδ expression activated transcriptional activity C2C12 myotubes. In palmitate-induced insulin-resistant myotubes,...
Ventricular arrhythmias arising from the fibrous rings have been demonstrated, but knowledge about aortomitral continuity (AMC) as a source of arrhytmias is still limited. The objective to describe characteristics ventricular originating AMC in patients without structural heart disease.Ten with tachycardia (VT) and/or premature contractions, who had successfully treated by catheter ablation at beneath aortic valve, were enrolled. Clinical data and electrocardiographic analysed. Three 10...