Abstract Background Previous studies reported the prognostic value of atherogenic index plasma (AIP) in course atherosclerosis and other cardiovascular diseases (CVDs). Still, predictive utility AIP is unknown among patients with type 2 diabetes mellitus (T2DM). Methods This was a secondary analysis Action to Control Cardiovascular Risk Diabetes (ACCORD) study, which randomized 10,251 long-lasting T2DM. ROC curve used determine an optimal threshold for AIP, study population divided into high...

Abstract Background The triglyceride-glucose (TyG) index is a reliable surrogate marker of insulin resistance and associated with major adverse cardiovascular events (MACEs) in patients type 2 diabetes mellitus (T2DM). However, the long-term effect TyG on incidence MACEs remains unclear. We aimed to investigate association between cumulative risk T2DM. Methods This post-hoc analysis Action Control Cardiovascular Risk Diabetes (ACCORD) trial assessed patients’ (T2DM > 3 months) MACE data...

OBJECTIVE Remnant cholesterol (remnant-C) predicts atherosclerotic cardiovascular disease, regardless of LDL-cholesterol (LDL-C) levels. This study assessed the associations between remnant-C and outcomes in type 2 diabetes. RESEARCH DESIGN AND METHODS post hoc analysis Action to Control Cardiovascular Risk Diabetes (ACCORD) trial used patient (type diabetes >3 months) major adverse event (MACE) data from database. The MACEs were evaluated using Cox proportional hazards regression...

Cardiovascular autonomic neuropathy (CAN), characterized by disrupted regulation of the cardiovascular system, is a frequent complication associated with diabetes. The triglyceride-glucose (TyG) index represents precise insulin resistance indicator. However, influence baseline and prolonged TyG patterns on CAN risk in type 2 diabetes remains unclear. Based Action to Control Risk Diabetes (ACCORD) trial, multivariate logistic regression models restricted cubic splines (RCS) were deployed for...

Background To determine the association of unintentional changes in body mass index (BMI) and waist circumference (WC) with risk heart failure (HF) among adults type 2 diabetes mellitus (T2DM). Methods This was a randomized controlled trial (the Action to Control Cardiovascular Risk Diabetes [ACCORD] study), double 2×2 factorial design conducted at 77 clinical centers across United States Canada. In total, study comprised 10,251 patients T2DM cardiovascular disease (CVD) or high CVD. The...

Background Although studies have shown that glycemic variability is positively associated with an increased risk of cardiovascular disease, few compared hemoglobin A1c (HbA1c) and fasting plasma glucose (FPG) adverse events in patients type 2 diabetes mellitus (T2DM). Methods This was a post hoc analysis the Action to Control Cardiovascular Risk Diabetes (ACCORD) study. Cox proportional hazards models were used explore relationship between HbA1c or FPG incidence major (MACEs). Results In...

Background: Since the coronavirus disease-2019 (COVID-19) outbreak, intensive care unit (ICU) healthcare workers were responsible for critical infected patients. However, few studies focused on mental health of ICU workers. This study aimed to investigate psychological impact COVID-19 in China. Methods: We distributed nine-item Patient Health Questionnaire (PHQ-9) and seven-item General Anxiety Disorder questionnaire (GAD-7) online Respondents divided into frontline second-line according...

This study aimed to evaluate the association between obesity, evaluated by fat mass index (FMI) with risk of microvascular diseases in patients type 2 diabetes mellitus (T2DM) and compare magnitude associations FMI, body (BMI), waist circumference (WC) diseases. We performed a post-hoc analysis Action Control Cardiovascular Risk Diabetes study. The primary outcomes present included chronic kidney disease (CKD) progression, retinopathy, neuropathy. Cox proportional-hazards models were FMI A...

Background and Aims This study aimed to evaluate the association of triglyceride-glucose (TyG) index with cardiovascular incidence in patients type 2 diabetes mellitus (T2DM). Methods Results Secondary analysis long-lasting T2DM from Action Control Cardiovascular Risk Diabetes was performed. The primary outcome first occurrence major adverse events (MACEs). between baseline trajectories TyG MACEs evaluated by Cox proportional hazards regression analysis. During a median follow-up period 8.8...

Previous studies have found that predicted fat mass and lean body may act differently on adverse events. However, the cardiovascular prognostic value of in patients with type 2 diabetes mellitus (T2DM) has not yet been investigated. We sought to investigate relation between or risk disease T2DM.We conducted a post hoc analysis data from Action Control Cardiovascular Risk Diabetes (ACCORD) study major events T2DM. used sex-specific quartiles index (BMI; kg/m2) (kg/m2). defined event as...

Background: Type 2 diabetes mellitus (T2DM) patients with depression are often accompanied by diabetic nephropathy. However, limited prospective studies have investigated the independent association between and nephropathy, as well its progression among T2DM patients. This study aims to investigate development or of nephropathy in patients, utilizing data from ACCORD Health‐Related Quality Life (HRQL) study. Methods Results: The nine‐item Patient Health Questionnaire (PHQ‐9) was utilized...

Background Recent evidence from cohort studies and meta‐analyses suggests that the obesity paradox phenomenon may exist in patients with diabetes mellitus. The goal of this study was to assess association between adverse events by using 2 different measures obesity, body mass index (BMI; kg/m ) waist circumference, a mean 10‐year history type Methods Results We used data ACCORD (the Action Control Cardiovascular Risk Diabetes) evaluate relationship primary outcome all‐cause mortality....

Although studies have shown that waist circumference (WC) is positively associated with an increased risk of cardiovascular diseases among the normal population, few investigated WC in patients type-2 diabetes mellitus (T2DM).This was a post hoc analysis Action to Control Cardiovascular Risk Diabetes (ACCORD) study. The Cox proportional hazards models used investigate relationship between and major adverse events (MACEs) T2DM disease (CVD) or high factors CVD.A total 10,251 (6299 men...

Endothelium-dependent relaxation (EDR) is an initial key step leading to various vascular complications in patients with diabetes. However, the underlying mechanism of EDR impairment diabetes not fully understood. Present study defined role high-mobility group protein (HMGB1) related Serum level HMGB1 was increased diabetic and db/db mice. also positively correlated HbA1c negatively nitric oxide (NO) patients. Results from wire myograph showed that recombinant (rHMGB1) capable impairing...

To determine whether cumulative blood pressure (BP) could predict stroke in individuals with type 2 diabetes (T2D). BP levels at baseline and the initial three visits were obtained from participating Action to Control Cardiovascular Risk Diabetes (ACCORD) trial who had not experienced a stroke. Cumulative elevations assessed by adding weighted mean values various time intervals. The association of was evaluated multivariate-adjusted Cox proportional hazard model analysis. Overall, 8282...

Background: The association between metabolic syndrome (MS) and bladder cancer (BC) was not fully investigated, most primary studies pooled analyses were only focused on certain specific components. Objective: To further investigate this issue obtain more precise findings, we conducted updated evidence synthesis of published studies, which involved MS components but also the in its entirety. Materials methods: We searched PubMed, EMBASE, Web Science databases for observational BC...

Monitoring and predicting the deformation of surrounding rocks in rock tunnel construction process is great significance. This study implemented a wireless sensor network (WSN), including gateway transmission, relay point, nodes, to obtain high granularity data during construction. A transformer model proposed, which considers sequence into positional embedding has an attention module deeply learn dimensionality correlation between nearby face deformation. The attention-enhanced LSTM are...

Background The impact of obesity on cognitive function in patients with type 2 diabetes mellitus (T2DM) remains controversial. This study aimed to evaluate whether obesity, assessed by body mass index (BMI) was associated among T2DM and the effect through brain structure. Methods a post-hoc analysis Action Control Cardiovascular Risk Diabetes–Memory Diabetes (ACCORD-MIND) study. test battery included Digit Symbol Substitution Test (DSST), Mini-Mental State Exam (MMSE), Rey Auditory Verbal...

Background Several studies have previously demonstrated that higher systolic blood pressure level means lower risk of adverse cardiovascular outcomes. However, there is a lack further investigation into the nonlinear relationship between admission (SBP) and outcomes acute myocardial infarction (AMI) patients. Objectives The aim this study was to investigate specific SBP incidence major events (MACE) in 30 days for AMI Methods results Using data from ACS-QUIK trial, we analyzed 21,364...

Self-management of blood glucose levels to avoid hypoglycemia is vital for patients with type 2 diabetes mellitus (T2DM). The association between specific metrics glycemic variability (glycosylated hemoglobin A1c [HbA1c] and fasting plasma [FPG]) severe has not been fully studied in T2DM.

Abstract Aims Studies on objectively measured physical activity (PA) have investigated acute cardiovascular outcomes but not cardiac arrest (CA). Our study aimed to investigate the dose–response relationship between accelerometer-measured PA and CA by intensity of PA. Methods results This prospective cohort included 98 893 UK Biobank participants whose data were using wrist-worn accelerometers. Total volume was average overall acceleration. Minutes per week light (LPA), moderate (MPA),...