A5103178023- Autophagy in Disease and Therapy
- Sleep and Wakefulness Research
- Neuroscience of respiration and sleep
- Endoplasmic Reticulum Stress and Disease
- Anesthesia and Neurotoxicity Research
- Data Management and Algorithms
- Intensive Care Unit Cognitive Disorders
- Mitochondrial Function and Pathology
- Cardiac Fibrosis and Remodeling
- Myasthenia Gravis and Thymoma
- Traditional Chinese Medicine Analysis
- Pharmacological Effects of Natural Compounds
- Obstructive Sleep Apnea Research
- Sustainability and Ecological Systems Analysis
- Peptidase Inhibition and Analysis
- Pregnancy and preeclampsia studies
- Context-Aware Activity Recognition Systems
- Cell death mechanisms and regulation
- Bioactive Natural Diterpenoids Research
- Parkinson's Disease Mechanisms and Treatments
- Inflammasome and immune disorders
- Signaling Pathways in Disease
- Alzheimer's disease research and treatments
- Adipose Tissue and Metabolism
- Heme Oxygenase-1 and Carbon Monoxide
Hangzhou First People's Hospital
2020-2025
Westlake University
2025
University of Miami
2024
Chinese University of Hong Kong
2015-2023
Zhejiang University
2011-2023
Qingdao University
2015-2021
Hangzhou Medical College
2016-2021
Affiliated Hospital of Qingdao University
2017-2021
Nanjing Forestry University
2017-2020
IBM Research (China)
2019
Diabetes mellitus is a significant global public health problem depicting rising prevalence worldwide. As serious complication of diabetes, diabetes-associated cognitive decline attracting increasing attention. However, the underlying mechanisms are yet to be fully determined. Both endoplasmic reticulum (ER) stress and autophagy have been reported modulate neuronal survival death associated with several neurodegenerative diseases. Here, streptozotocin-induced diabetic mouse model primary...
Poor management of DM causes cognitive impairment while the mechanism is still unconfirmed. The aim present study was to investigate activation C/EBP Homology Protein (CHOP), prominent mediator endoplasmic reticulum (ER) stress-induced apoptosis under hyperglycemia. We employed streptozotocin- (STZ-) induced diabetic rats explore ability learning and memory by Morris water maze test. ultrastructure hippocampus in cultured neurons high glucose medium were observed transmission electron...
This study examined the role of endoplasmic reticulum (ER) stress in mediating chronic intermittent hypoxia (IH)-induced neurocognitive deficits. We designed experiments to demonstrate that ER is initiated hippocampus under IH and determined its apoptotic cell death, impaired synaptic structure plasticity, memory deficits.Two weeks disrupted fine upregulated markers, glucose-regulated protein 78, caspase-12, C/EBP homologous protein, hippocampus, which could be suppressed by inhibitors,...
Abstract Small cell lung cancer (SCLC) is a severe malignant with high morbidity; however, few effective and secure therapeutic strategy used in current clinical practice. Oridonin small molecule from the traditional Chinese herb Rabdosia rubescens. This study mainly aimed to investigate role of oridonin on inhibiting process H1688, kind cells human. could suppress H1688 proliferation induce their apoptosis dosage treatment (20 μmol/L). Meanwhile, migration was suppressed by (5 10 μmol/L)...
Tumour necrosis factor superfamily protein 14 (TNFSF14), also called LIGHT, is an important regulator of immunological and fibrosis diseases. However, its specific involvement in cardiac atrial fibrillation (AF) has not been fully elucidated. The objective this study to examine the influence LIGHT on development myocardial AF.
Chinese herbs have been used to treat small-cell lung cancer (SCLC) due their low toxicity and significant efficacy. This study focused on oridonin, a natural compound extracted from Rabdosia rubescens, aimed investigate its potential antitumor activity SCLC evaluate the synergistic effect of combining oridonin with other small molecules. In this study, exhibited dual effect. At lower concentrations, it suppressed cell viability cells (H1688 H446). high induced apoptosis, damaged HBE in...
Mesenchymal stem cells (MSCs) are one promising candidate for regenerative therapy of ischaemic stroke through transdifferetiation and paracrine actions. Icariin (ICA) has shown great potential in improving cell activity VEGF, BDNF secretion vitro. Whether they will synergistically improve effect on cerebral ischemia is unknown. In this study, male SD rats were subjected to transient middle artery occlusion (MCAO) followed by reperfusion ICA/MSC treatment. Results showed that ICA MSCs...
Our previous study showed that growth arrest- and DNA damage-inducible gene 153 (GAD153/CHOP) plays an important role in intermittent hypoxia- (IH-) induced apoptosis impaired synaptic plasticity. This is aimed at determining which signaling pathway activated to induce CHOP the of this protein mitochondria-dependent by IH. In vivo study, mice were placed IH chambers for 8 h daily over a period 2 weeks; had oxygen (O2) concentrations oscillated between 10% 21%, cycling every 90 s. vitro PC12...
Myocardial infarction (MI) and subsequent ischaemic cardiomyopathy (ICM) are the primary causes of heart failure. Inter-α trypsin inhibitor heavy chain 5 (ITIH5) is an extracellular matrix (ECM) protein has been identified as a myocardial marker ICM. However, its diagnostic value in patients with ICM function molecular mechanism regulating cardiac repair remodelling after MI remain unknown. Three microarray datasets including 117 152 non-failing (NF) tissue samples were merged analysed....
Erectile dysfunction (ED) is a common complication of diabetes. This study aimed to explore the beneficial effect Danshen injection on ED in streptozotocin (STZ)-induced diabetic rat model and underlying mechanism. The was established by an intraperitoneal 60 mg/kg STZ male Sprague-Dawley rats. rats were intraperitoneally injected with solution (0.5 or 1 mL/kg/day) same volume saline for 6 weeks. Age-matched served as controls. After weeks, erectile function histological morphology corpora...
Glyphosate is the active ingredient in numerous herbicide formulations. The role of glyphosate neurotoxicity has been reported human and animal models. However, detailed mechanism neuronal development remains unknown. Recently, several studies have evidence linking neurodevelopmental disorders (NDDs) with gestational exposure. current group previously identified microRNAs (miRNAs) that are associated etiology NDDs, but their expression levels developing brain following exposure not...
The Chinese honey locust tree Gleditsia sinensis Lam. (Fabaceae) is a precious ecological and economic species that has wide-ranging usage. However, knowledge regarding seedling cultivation (especially the use of arbuscular mycorrhizal fungi (AMF)) scarce, which limits developent plantations. A pot experiment was carried out under greenhouse conditions to estimate effects three AMF strains (Funneliformis mosseae 1, Funneliformis 2, Diversispora tortuosa) on growth, photosynthetic rate,...
Abstract Background Obstructive sleep apnea (OSA) is associated with pulmonary fibrosis and endothelial apoptosis in tissues. Chronic intermittent hypoxia (IH) considered to be the primary player OSA, but mechanisms underlying its effect on tissues are unknown. Endoplasmic reticulum (ER) stress induced by IH treatment plays an important role accelerating process of induction apoptosis. Methods Mice were placed chambers for 4 weeks oscillating oxygen (O 2 ) concentration between 5 21%,...