A5100659416- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Spine and Intervertebral Disc Pathology
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Scoliosis diagnosis and treatment
- Cancer Mechanisms and Therapy
- Cancer-related molecular mechanisms research
- Genetic factors in colorectal cancer
- Liver physiology and pathology
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Spinal Fractures and Fixation Techniques
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Metastasis and carcinoma case studies
- Lung Cancer Diagnosis and Treatment
- Cancer Cells and Metastasis
- Hip disorders and treatments
- Chemokine receptors and signaling
- Air Quality and Health Impacts
Fudan University
2012-2025
Zhongshan Hospital
2012-2025
Army Medical University
2021-2025
Chongqing Medical University
2021-2025
Second Affiliated Hospital of Chongqing Medical University
2021-2025
Dalian Medical University
2021-2025
People 's Hospital of Jilin Province
2025
Tianjin Chest Hospital
2018-2025
Tianjin University
2024-2025
Union Hospital
2024
CXCL5 (epithelial neutrophil-activating peptide-78) is a member of proangiogenic subgroup the CXC-type chemokine family small, secreted proteins. Recently, evidence that involved in carcinogenesis and cancer progression has emerged. To investigate role tumor growth, invasion, prognosis hepatocellular carcinoma (HCC), we examined messenger RNA (mRNA) protein levels HCC cell lines with various metastatic potentials three independent cohorts 919 patients. We found expression was increased...
MicroRNAs (miRNAs) play a critical role in regulation of tumor metastasis. However, the these molecules hepatocellular carcinoma (HCC) has not been fully elucidated. In this study, we employed miRNA‐sequencing and identified 22 miRNAs involved HCC One these, miR‐28‐5p, was down‐regulated HCCs. This down‐regulation correlated with metastasis, recurrence, poor survival. Biofunctional investigations revealed that miR‐28‐5p deficiency promoted growth metastasis nude mice without altering vitro...
Abstract Purpose: Novel therapeutic strategies are needed to prevent the tumor recurrence or metastasis after liver transplantation for hepatocellular carcinoma (HCC). This study was investigate effect of rapamycin, alone and in combination with sorafenib, on HCC vivo. Experimental Design: Xenograft a highly metastatic human (LCI-D20) used evaluate primary growth lung treatment rapamycin sorafenib. Tumor cell proliferation determined by Ki-67 immunostaining. To detect apoptosis, terminal...
Early detection of primary liver cancer (PLC), including HCC, intrahepatic cholangiocarcinoma (ICC), and combined HCC-ICC (cHCC-ICC), is essential for patients' survival. This study aims to develop an accurate affordable method PLC early differentiating ICC from HCC using plasma cell-free DNA (cfDNA) fragmentomic profiles.Whole-genome sequencings (WGS) were performed cfDNA samples 192 patients with (159 26 ICC, 7 cHCC-ICC) 170 noncancer controls (including 53 cirrhosis [LC] or HBV-positive)...
Numerous studies have demonstrated limited survival benefits of transarterial chemoembolization (TACE) alone in the treatment intermediate-stage hepatocellular carcinoma (HCC) beyond up-to-seven criteria. The advent immunotherapy, particularly immune checkpoint inhibitors (ICIs), has opened new avenues for HCC treatment. However, TACE combined with ICIs not been investigated patients study aims to evaluate efficacy and safety this strategy such patients. In single-arm, prospective, phase II...
The aim of the study is to assess efficacy and safety associating liver partition portal vein ligation for staged hepatectomy (ALPPS) in patients with hepatitis B virus-related hepatocellular carcinoma (HCC).ALPSS allows curative resection conventionally-unresectable tumors. However, its role HCC largely unknown.Consecutive who underwent ALPPS at our center between April 2013 September 2017 were retrospectively studied. oncological results compared receiving transcatheter arterial...
The elevated platelet-to-lymphocyte ratio (PLR), determined using an easy blood test based on platelet and lymphocyte counts, is reported to be a predictor of poor survival in patients with several cancers. prognostic role preoperative PLR intrahepatic cholangiocarcinoma (ICC) has, until now, been rarely investigated. purpose our study was evaluate the significance large cohort ICC after hepatic resection. We obtained data from 322 consecutive nonmetastatic who underwent hepatectomy without...
Abstract Context The association between remnant cholesterol (remnant-C) and cardiovascular mortality in patients with type 2 diabetes (T2D) incident diabetic nephropathy remains unclear. Objective To examinie the remnant-C T2D, chronic kidney disease (CKD) stages 3 to 5, newly diagnosed DN. Methods This study determined baseline lipid profile searched for deaths (CVD) within years of among 2282 adults enrolled January 1, 2015 December 31, 2016, who had CKD Adjusted logistic regression...
Abstract Diabetic foot ulcer typically undergoes a delayed wound‐healing process owing to the disordered microenvironment, including persistent inflammation, long‐term hypoxia, and excessive fibrosis, eventually leading severe disabilities other poor outcomes. However, current strategies cannot meet dynamic demands during process. Herein, reactive oxygen species (ROS)–responsive oxygen‐generating microneedle platform, consisting of sericin‐based glucose‐responsive hydrogel loaded with...
Calpain small subunit 1 (Capn4) has been identified as a major gene that promotes metastasis of hepatocellular carcinoma (HCC). However, the mechanism by which Capn4 progression HCC is not understood. In this study, we found expression was increased in highly metastatic cell lines and tumour tissue from patients compared to healthy patient tissue. Over-expression cells enhanced growth vitro invasiveness, tumourigenicity lung vivo. Protein microarray analyses showed multiple proteins...
Background Rapamycin is an attractive approach for the treatment and prevention of HCC recurrence after liver transplantation. However, objective response rates rapamycin achieved with single-agent therapy were modest, supporting that resistance a frequently observed characteristic many cancers. Some studies have been devoted to understanding mechanisms resistance, however, are cell-type-dependent on in extremely limited. Methodology/Principal Findings The anti-tumor sensitivity was modest...
Study Design. Retrospective cohort study. Objective. To illustrate the technique of modified transpedicular subtraction and disc osteotomy combined with long-segment fixation for treatment Kümmell disease neurologic deficits to evaluate clinical radiographic results patients treated technique. Summary Background Data. is a condition in which develop kyphosis lower thoracolumbar spinal region months years after sustaining an otherwise asymptomatic minor spinal. Currently, neurological...
The clinical benefits of combining immunotherapy with chemotherapy and surgical resection in pancreatic adenocarcinoma remain unclear. expression significance HIF1A circulating tumor cells (CTCs) remains limited.
Background Nicotinamide (NAM) metabolism fulfills crucial functions in tumor progression. The present study aims to establish a NAM metabolism-correlated gene (NMRG) signature assess the immunotherapy response and prognosis of lung adenocarcinoma (LUAD). Methods training set validation (the GSE31210 dataset) were collected Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO), respectively. Molecular subtypes LUAD classified by consensus clustering. Mutation landscape top 20 somatic genes...
Neoadjuvant chemotherapy (NAC) can improve the survival outcomes of patients with pancreatic cancer, but for borderline resectable cancer (BRPC) proportion conversion to surgery remains unsatisfactory. This single-arm pilot study aimed assess clinical efficacy and safety NAC based on patient-derived organoids (PDOs) BRPC. Biopsy samples from BRPC were collected generating PDOs. Gemcitabine plus nab-paclitaxel (GnP) as was initially administrated one cycle, then treatment regimen adjusted PDO...
Background: As urbanization progresses, the resulting air pollution has become an increasingly severe public health issue, known to exacerbate respiratory and cardiovascular diseases. Recent studies suggest that it may also affect blood coagulation mechanisms. In this study, Mendelian randomization (MR) analysis was used explore causal relationship between pulmonary embolism (PE). Methods: This study employs MR techniques, using genetic variants associated with exposure assess their impact...
Colorectal cancer (CRC) is a significant worldwide health issue, ranking second in women and third men. Predictions estimate rise to 2.5 million cases by 2035, with CRC being the fourth deadliest due delayed diagnosis scarcity of effective treatment options. Over 60% involve MAPK-activated signal pathways, particularly driven RAS oncogene mutations, which hinder responses, making them 'undruggable.' This study conducts two-sample Mendelian randomization protein quantitative trait loci (pQTL)...
Phosphomannopentaose sulfate (PI-88), an effective inhibitor of heparanase (HPSE), exhibited anti-recurrence and anti-metastasis activity in preliminary clinical trials hepatocellular carcinoma (HCC); however, the underlying mechanisms remain uncertain. Our aim was to reveal mechanism by which PI-88 inhibits recurrence intrahepatic metastasis. A tissue microarray containing samples from 352 HCC patients used determine HPSE expression. We performed enzyme-linked immunosorbent assay (ELISA)...
Early recurrence after hepatectomy for intrahepatic cholangiocarcinoma (ICC) has a great effect on the long-term survival outcomes of patients. We conducted this study to identify risk factors early and clarify whether is related ICC patients' outcomes. 322 patients who underwent partial at Liver Cancer Institute Zhongshan Hospital between January 2005 December 2011 were included in retrospectively study. was defined as within two years hepatectomy. identified total 168 with 23 late From...