A5080907045- Renal Diseases and Glomerulopathies
- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Blood Pressure and Hypertension Studies
- Gut microbiota and health
- Systemic Lupus Erythematosus Research
- Vasculitis and related conditions
- Liver Disease Diagnosis and Treatment
- Diabetes Treatment and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer-related molecular mechanisms research
- Diabetes Management and Education
- Diet and metabolism studies
- Renal and Vascular Pathologies
- Pediatric Urology and Nephrology Studies
- Chronic Disease Management Strategies
- Lipid metabolism and disorders
- Diabetes Management and Research
- Systemic Sclerosis and Related Diseases
- Gout, Hyperuricemia, Uric Acid
- MicroRNA in disease regulation
- Potassium and Related Disorders
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Renal and related cancers
- Heart Failure Treatment and Management
First Affiliated Hospital of Zhengzhou University
2016-2025
Zhejiang Chinese Medical University
2019-2025
Zhengzhou University
2015-2025
First Affiliated Hospital of Jinan University
2021-2025
University of Coimbra
2024
Icahn School of Medicine at Mount Sinai
2024
Shanxi Medical University
2023
Second Hospital of Shanxi Medical University
2023
Wuhan University
2023
Renmin Hospital of Wuhan University
2023
Abstract A major cause of proteinuria in lupus nephritis (LN) is podocyte injury, and determining potential therapeutic targets to prevent injury important from a clinical perspective the treatment LN. CD36 involved several glomerulopathies was reported be vital candidate gene Here, we determined role LN underlying mechanisms. We observed that NLRP3 (NLR family pyrin domain containing 3) were upregulated podocytes patients MRL/lpr mice with renal impairment. In vitro, CD36, inflammasome,...
Diabetic nephropathy is one of the most prevalent chronic complications Diabetes mellitus, but its pathogenesis remains elusive. This study was designed to determine role tristetraprolin (TTP), inflammatory cytokines and microRNAs (miRNAs) in DN. The blood urine samples were obtained from 32 patients with DN, 33 type 2 DM, 35 normal healthy subjects as controls. Renal tissue also 10 DN miRNA microarray analyses performed pooled plasma sediment eight age- sex-matched health control three...
Abstract Long‐term peritoneal dialysis (PD) often ends up with ultrafiltration failure (UFF) which is partially caused by persistent inflammation and fibrosis of tissues. However, the mechanism still unclear. In current study, peritoneum from UFF patients demonstrated were positively related to expression vascular endothelial growth factor A (VEGFA). The in vitro model using human mesothelial cells (HPMCs) stimulated high glucose or advanced glycation end (AGE) product showed consistent...
Long-term peritoneal dialysis (PD) therapy results in functional and structural alteration of the membrane, including epithelial-to-mesenchymal transition (EMT). Interleukin 6 (IL-6) is a local pleiotropic cytokine, hypothesized to play an important role EMT. This study was designed investigate IL-6 EMT membrane dysfunction long-term PD patients by assessing level dialysate exploring relationship between IL-6, related signaling pathway JAK2/STAT3, EMT, using vitro cellular molecular...
Background . Hyperuricemia is known to be a risk factor for diabetes. However, information limited regarding the association between changes in hyperuricemia and of Methods A total 15,403 participants who were free diabetes at time 2009 2011 surveys Beijing Health Management Cohort (BHMC) study recruited followed up until 2016. Participants classified into four groups according 2-year hyperuricemia: no hyperuricemia, remittent incident persistent hyperuricemia. Modified Poisson regression...
Abstract Context The association between remnant cholesterol (remnant-C) and cardiovascular mortality in patients with type 2 diabetes (T2D) incident diabetic nephropathy remains unclear. Objective To examinie the remnant-C T2D, chronic kidney disease (CKD) stages 3 to 5, newly diagnosed DN. Methods This study determined baseline lipid profile searched for deaths (CVD) within years of among 2282 adults enrolled January 1, 2015 December 31, 2016, who had CKD Adjusted logistic regression...
Diabetes mellitus is a metabolic disease closely related to disordered gut microbiome. Diabetic patients usually suffer from various disorders, such as increased serum uric acid levels. Although levels depend partially on intestine excretion, the relationship between and microbiome in diabetic remains unknown. We collected total of 126 fecal samples for 16S ribosomal RNA gene amplicon sequencing recorded clinical data. analyzed correlation indicators microbiota using Spearman analysis. Since...
Diabetic nephropathy (DN) is characterized by inflammation of renal tissue. Glomerular endothelial cells (GEnCs) play an important role in and protein leakage urine DN patients. Chemerin its receptor ChemR23 are inducers inflammation. The aim this study was to investigate the function chemerin/ChemR23 GEnCs Immunohistochemical staining qRT-PCR were used measure expression chemerin, inflammatory factors tissues Db/db mice as animal model. knocked down injecting LV3-shRNA into tail vein....
Type 2 diabetes affects Indigenous and non-European populations disproportionately, including in New Zealand, where long-term temporal trends cause-specific clinical outcomes between Māori, Pacific, European people remain unclear. We aimed to compare the rates of mortality hospital admission patients with type Auckland, over a period 24 years.In this retrospective, population-based, longitudinal cohort study, we identified (aged 35-84 years) enrolled Jan 1, 1994, July 31, 2018, primary care...
An immunosuppressive tumor microenvironment limits the efficacy of immunotherapy, thus patients with MSS and pMMR mCRC often face great challenges.In this phase II trial, received Gamma Knife SBRT combined Tislelizumab. P Biomarker analysis was performed pre- post-treatment. From November 2022 to July 2024, 13 20 achieved PR, 6 SD. mPFS 10.7 months (95% CI, 6.4-15.0). With no grade 4 events noted, common adverse included nausea (65%), anemia (55%), fatigue (45%). For who had not responded...
An immunosuppressive tumor microenvironment limits the efficacy of immunotherapy, thus patients with MSS and pMMR mCRC often face great challenges.In this phase II trial, received Gamma Knife SBRT combined Tislelizumab. P Biomarker analysis was performed pre- post-treatment. From November 2022 to July 2024, 13 20 achieved PR, 6 SD. mPFS 10.7 months (95% CI, 6.4-15.0). With no grade 4 events noted, common adverse included nausea (65%), anemia (55%), fatigue (45%). For who had not responded...
Prostatic ductal adenocarcinoma (PDA) is a rare malignant tumor, and research on its clinical features prognosis scarce. This study aims to develop prognostic nomograms predict the overall survival (OS) cancer-specific (CSS) in patients with PDA. Among 1,049 identified patients, an 8:2 random division yielded development validation cohorts. Univariate multivariate Cox analyses were performed identify independent factors, which then incorporated into predicting 1-, 3-, 5-year OS CSS for The...
Anti-glomerular basement membrane (anti-GBM) disease is a rare and life-threatening form of small vessel vasculitis that primarily affects the kidneys lungs. In cases, it occurs with membranous nephropathy (MN). This study aimed to investigate clinical manifestations, pathological features, prognosis predictors anti-GBM MN. We enrolled 24 patients combined MN, 69 classic (without MN). compared differences, as well prognoses between two groups attempted identify A greater proportion were...
Objectives This study aimed to analyze the potential of estimated protein excretion rate (ePER) as a substitute for spot urinary protein-creatinine ratio (uPCR) in clinical reports accurately assessing China. Methods We included 1721 patients and compared differences levels, correlation, bias, methodological evaluation between uPCR, ePER, 24-h protein. Results Significant ( Z = −17.568, p < 0.001) were found uPCR urine levels all cases. However, no statistically significant difference...
The association between membranous nephropathy (MN) and malignant tumors has long been focused. However, most existing studies have primarily concentrated on patients diagnosed with within a limited timeframe, typically defined as one year before or after the diagnosis of MN. This narrow focus only captures subset MN complicated by tumors, leaving those outside this timeframe understudied largely unexplored. In present study, we aim to comprehensively investigate clinicopathological...
The prognosis of human astrocytoma is poor, and the molecular alterations underlying its pathogenesis still needed to be elucidated. Nucleolar spindle associated protein 1 (NUSAP1) was observed in several types cancers, but role remained unknown. expression NUSAP1 cell lines tissues were measured with western blotting Real-Time PCR. Two hundred twenty-one tissue samples analyzed by immunochemistry demonstrate correlation between clinicopathological characteristics....
Background Diabetic kidney disease (DKD) and membranous nephropathy (MN) are the two major causes of end-stage renal (ESRD). Increasing evidence has shown that intestinal dysbiosis is associated with many diseases. The aim this study was to explore composition gut microbiome in DKD MN patients.Methods 16S rRNA gene sequencing performed on 271 fecal samples (DKD = 129 142), taxonomic annotation microbial function completed.Results We observed distinct communities between groups, exhibiting...
Abstract Membranous nephropathy (MN) is a common cause of nephrotic syndrome. The aim to establish non‐invasive diagnostic model MN using differential gut microbiome analysis, and explore the relationship between pathogenesis in vivo. 825 fecal samples from patients healthy participants are collected multiple medical centers across China. Key operational taxonomic units (OTUs) obtained through 16S rRNA sequencing used model. A rat developed MN. diversity richness significantly lower with...