A5102893539- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Liver Disease Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Crystallization and Solubility Studies
- Circular RNAs in diseases
- X-ray Diffraction in Crystallography
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- Cardiac electrophysiology and arrhythmias
- Chronic Kidney Disease and Diabetes
- Glycosylation and Glycoproteins Research
- Cancer Immunotherapy and Biomarkers
- Renal Diseases and Glomerulopathies
- Pregnancy and preeclampsia studies
- Cancer, Lipids, and Metabolism
- Liver Disease and Transplantation
- Cancer Genomics and Diagnostics
- Renal cell carcinoma treatment
- Lipid metabolism and disorders
- Hepatitis B Virus Studies
- Gestational Diabetes Research and Management
- Obstructive Sleep Apnea Research
Zhengzhou University
2013-2025
First Affiliated Hospital of Zhengzhou University
2020-2025
Second Military Medical University
2017-2025
Changhai Hospital
2019-2025
Kunming Medical University
2014-2025
China National Pharmaceutical Group Corporation (China)
2025
Jining University
2025
Heilongjiang University
2025
Henan Provincial People's Hospital
2013-2025
Sun Yat-sen University
2016-2024
Circulating miRNAs (microRNAs) are emerging as promising biomarkers for several pathological conditions, and the aim of this study was to investigate feasibility using serum liver pathologies. Real-time qPCR (quantitative PCR)-based TaqMan MicroRNA arrays were first employed profile in pools from patients with HCC (hepatocellular carcinoma) or LC (liver cirrhosis) healthy controls. Five (i.e. miR-885-5p, miR-574-3p, miR-224, miR-215 miR-146a) that up-regulated selected further quantified...
Rationale: Cancer stem cells (CSCs) are considered to be essential for tumorigenesis, recurrence, and metastasis therefore serve as a biomarker tumor progression in diverse cancers.Recent studies have illustrated that specific miRNAs exhibit novel therapeutic potential by controlling CSC properties.miR-1275 is upregulated lung adenocarcinoma (LUAD) enhances its stemness.However, the underlying mechanisms not been elucidated.Methods: miRNA expression microarray of LUAD adjacent nontumor...
Variability in CYP3A (CYP3A4/5) and P-glycoprotein (human MDR1 gene product) activity underlies interindividual differences oral cyclosporine (CsA) bioavailability. Racial polymorphic expression of CYP3A5 may explain observed interracial variability Our objective was to evaluate the effect on CsA disposition. Steady-state plasma concentration profiles (n = 19) were sampled renal transplant recipients receiving concentration-adjusted maintenance therapy. concentrations measured by...
Background Long noncoding RNAs (lncRNAs) have been shown to be involved in the development and progression of lung cancer. However, roles lncRNAs cancer are not well understood. Methodology/Principal Findings We used a high-throughput microarray compare lncRNA messenger RNA (mRNA) expression profiles adenocarcinoma normal tissue (NT) samples. Several candidate adenocarcinoma-associated were verified by real-time quantitative reverse transcription polymerase chain reaction (PCR) analysis....
Neuroendocrine prostate cancer (NEPC) is a lethal subtype of cancer, with 10% five-year survival rate. However, little known about its origin and the mechanisms governing emergence. Our study characterized ADPC NEPC in tumors from 7 patients using scRNA-seq. First, we identified two gene expression signatures representing different phases trans-differentiation. New marker genes may be used for clinical diagnosis. Second, integrative analyses combining subclonal architecture revealed paths by...
Interleukin-33 (IL-33), a newly recognized IL-1 family member, is expressed in various tissues and cells, involved pathogenesis of many human diseases. For example, IL-33 plays protective role cardiovascular However, the acute ischemic stroke (AIS) remains unclear. This study aims to investigate whether level AIS patient serum can be used as potential diagnostic prognostic marker. The included two hundred six patients with first-ever stroke, who were admitted within 72 hours after onset. was...
Background Ventricular arrhythmia after myocardial infarction is the most important risk factor for sudden cardiac death, which poses a serious threat to human health. As correlation between autonomic nervous systemic dysfunction and heart rhythm abnormality has been gradually revealed, remedies targeting system dysfunction, especially sympathetic nerve, have emerged. Among them, renal denervation noted its powerful effect on inhibition of nerve activity. We aim investigate whether can...
Inflammatory diseases including COVID-19 are associated with a cytokine storm characterized by high interleukin-6 (IL-6) titers. In particular, while recent studies examined arrhythmic risks from cardiac injury and/or pharmacotherapy such as the combination of azithromycin (AZM) and hydroxychloroquine (HCQ), role IL-6 per se in increasing risk remains poorly understood. The objective is to elucidate electrophysiological basis inflammation-associated presence AZM HCQ. IL-6, HCQ were...
Timely and accurate identification of harmful bacterial species in the environment is paramount for preventing spread diseases ensuring food safety. In this study, laser-induced breakdown spectroscopy technology was utilized, combined with four machine learning methods - KNN, PCA-KNN, RF, SVM, to conduct classification research on 7 different types bacteria, adhering various substrate materials. The experimental results showed that despite nearly identical elemental composition these...
The ternary organic solar cells (OSCs) have been proven to be an effective strategy for achieving high power conversion efficiency (PCE), exhibiting substantial potential continuous enhancement of device performance. In this work, a novel nonfullerene acceptor, IDT-FN, is developed utilizing renowned indacenodithiophene (IDT) core and moderately intense electron-withdrawing terminal groups, serving as the third component in OSCs. IDT-FN demonstrates excellent complementary light absorption...
The association between membranous nephropathy (MN) and malignant tumors has long been focused. However, most existing studies have primarily concentrated on patients diagnosed with within a limited timeframe, typically defined as one year before or after the diagnosis of MN. This narrow focus only captures subset MN complicated by tumors, leaving those outside this timeframe understudied largely unexplored. In present study, we aim to comprehensively investigate clinicopathological...
Lung adenocarcinoma (LUAD) is a leading cause of cancer-related mortality, underscoring the urgent need for novel biomarkers and therapeutic targets. Through transcriptomic analysis 4456 genes in TCGA-LUAD cohorts, we identified RBMS3 as significantly downregulated tumor suppressor (log2 fold change = -1.82, adjusted P 3.2 × 10⁻5). Clinically, elevated expression was independently associated with improved overall survival (HR 0.766, 95% CI 0.602-0.973, 0.029), validated by Kaplan-Meier...
ABSTRACT The primary objective aims to evaluate the therapeutic efficacy of echinacoside in ameliorating hepatic steatosis and exploring its role modulating autophagic flux through AMP‐activated protein kinase (AMPK) signaling, positioning it as a potential treatment for non‐alcoholic fatty liver disease (NAFLD). A well‐established NAFLD rat model was employed, administering varying concentrations echinacoside. Biochemical parameters, including triglycerides (TG), total cholesterol (TC),...
Trigonelline, one of the active compounds from
Abstract Background SRSF1, a member of Serine/Arginine-Rich Splicing Factors (SRSFs), has been observed to significantly influence cancer progression. However, the precise role SRSF1 in osteosarcoma (OS) remains unclear. This study aims investigate functions and its underlying mechanism OS. Methods expression level OS was evaluated on TCGA dataset, TAGET-OS database. qRT-PCR Western blotting were employed assess human cell lines as well interfered ectopic states. The effect migration,...