A5100407506- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Virus-based gene therapy research
- GABA and Rice Research
- Blood Coagulation and Thrombosis Mechanisms
- Cancer Research and Treatments
- Lung Cancer Treatments and Mutations
- Influenza Virus Research Studies
- Gastric Cancer Management and Outcomes
- Functional Brain Connectivity Studies
- Circular RNAs in diseases
- Abdominal Surgery and Complications
- Sarcoma Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Neurological Disease Mechanisms and Treatments
- Computational Drug Discovery Methods
- Protease and Inhibitor Mechanisms
- Drug Transport and Resistance Mechanisms
- Traumatic Brain Injury Research
- Ferroptosis and cancer prognosis
- Glioma Diagnosis and Treatment
- Pharmacological Effects of Natural Compounds
- Cholinesterase and Neurodegenerative Diseases
- Advanced biosensing and bioanalysis techniques
- Neuroinflammation and Neurodegeneration Mechanisms
Yangzhou University
2017-2025
Tongji Hospital
2016-2025
Air Force Medical University
2013-2025
Xijing Hospital
2013-2025
Huazhong University of Science and Technology
2016-2025
Anhui Medical University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2011-2025
Chinese Academy of Agricultural Sciences
2025
Ministry of Agriculture and Rural Affairs
2025
State Key Laboratory of Electrical Insulation and Power Equipment
2024
Increasing evidences suggest that circular RNAs (circRNAs) exert crucial functions in regulating gene expression. In this study, we perform RNA-seq and identify 6,154 distinct circRNAs from human bladder cancer normal tissues. We find hundreds of are significantly dysregulated further show circHIPK3, also named cancer-related RNA-2 (BCRC-2), is down-regulated tissues cell lines, negatively correlates with grade, invasion as well lymph node metastasis, respectively. Over-expression circHIPK3...
Berberine, a botanical alkaloid used to control blood glucose in type 2 diabetes China, has recently been reported activate AMPK. However, it is not clear how AMPK activated by berberine. In this study, activity and action mechanism of berberine were investigated vivo vitro. dietary obese rats, increased insulin sensitivity after 5-wk administration. Fasting HOMA-IR decreased 46 48%, respectively, the rats. cell lines including 3T3-L1 adipocytes, L6 myotubes, C2C12 H4IIE hepatocytes, was...
Abstract It is well established that ferroptosis primarily induced by peroxidation of long-chain poly-unsaturated fatty acid (PUFA) through nonenzymatic oxidation free radicals or enzymatic stimulation lipoxygenase. Although there emerging evidence saturated (SFA) might be implicated in ferroptosis, it remains unclear whether and how SFA participates the process ferroptosis. Using endogenous metabolites genome-wide CRISPR screening, we have identified FAR1 as a critical factor for...
Abstract Objective Evaluating the efficacy of 3,6’‐dithioPomalidomide in 5xFAD Alzheimer's disease (AD) mice to test hypothesis that neuroinflammation is directly involved development synaptic/neuronal loss and cognitive decline. Background Amyloid‐β (Aβ) or tau‐focused clinical trials have proved unsuccessful mitigating AD‐associated impairment. Identification new drug targets needed. Neuroinflammation a therapeutic target neurodegenerative disorders, TNF‐α pivotal neuroinflammatory driver....
Abstract Emerging evidence reveals that amino acid metabolism plays an important role in ferroptotic cell death. The conversion of methionine to cysteine is well known protect tumour cells from ferroptosis upon starvation through transamination. However, whether acids‐produced metabolites participate independent the pathway largely unknown. Here, authors show tryptophan serotonin (5‐HT) and 3‐hydroxyanthranilic (3‐HA) remarkably facilitate escape distinct cysteine‐mediated inhibition....
Neurons express a variety of plasma-membrane potassium channels that play important roles in regulating neuronal excitability and synaptic transmission, but also contain mitochondrial ATP-sensitive channels, the functions which are unknown. Studies cardiac cells suggest similar involved process ischemic preconditioning, suggesting role cell survival. The authors report mice given diazoxide, an activator exhibited large (60% to 70%) decrease cortical infarct size after permanent occlusion...
A suppression subtractive cDNA library representing mRNAs expressed at a higher level in the malignant human breast cancer cell line, MCF-7, relative to benign tumor-derived Huma 123, contained cDNA, M36, which was estrogen receptor alpha (ERalpha)-positive carcinoma lines but not from normal/benign/ERalpha-negative lesions. M36 had an identical coding sequence anterior gradient 2 (AGR2), homologue of cement gland-specific gene (Xenopus laevis). Screening tumor specimens using reverse...
Abstract People who develop bladder cancer frequently succumb to the intractable disease. Current treatment strategies are limited presumably due underlying molecular complexity and insufficient comprehension. Therefore, exploration of new therapeutic targets in remains necessary. Here, we identify that bromodomain-4 protein (BRD4), an important epigenome reader bromodomain extraterminal domain (BET) family member, is a key upstream regulator enhancer zeste homologue 2 (EZH2), represents...
The vertebrate inner ear develops from the otic placode, an ectodermal thickening that forms adjacent to presumptive hindbrain. Previous studies have suggested competent cells respond signals tissues form placode. Members of Fgf family growth factors and Dlx transcription been implicated in this signal-response pathway. We show compromising Fgf3 Fgf8 signaling blocks development; only a few scattered form. Removal dlx3b, dlx4b sox9a genes together also development, although residual...
Diabetic nephropathy is one of the most prevalent chronic complications Diabetes mellitus, but its pathogenesis remains elusive. This study was designed to determine role tristetraprolin (TTP), inflammatory cytokines and microRNAs (miRNAs) in DN. The blood urine samples were obtained from 32 patients with DN, 33 type 2 DM, 35 normal healthy subjects as controls. Renal tissue also 10 DN miRNA microarray analyses performed pooled plasma sediment eight age- sex-matched health control three...
Abstract Long‐term peritoneal dialysis (PD) often ends up with ultrafiltration failure (UFF) which is partially caused by persistent inflammation and fibrosis of tissues. However, the mechanism still unclear. In current study, peritoneum from UFF patients demonstrated were positively related to expression vascular endothelial growth factor A (VEGFA). The in vitro model using human mesothelial cells (HPMCs) stimulated high glucose or advanced glycation end (AGE) product showed consistent...
Purpose: The study investigated the impact of TP53 mutations on clinical efficacy first-generation EGFR-tyrosine kinase inhibitors (TKIs) in Chinese patients with advanced or recurrent non-small-cell lung cancer (NSCLC). Patients and methods: Tissues from 163 NSCLC at Affiliated Hospital Qingdao University were analyzed by next-generation sequencing (NGS) to determine mutational status EGFR concurrent genetic alterations. evaluated relation baseline patient characteristics treatment outcomes...
To investigate the roles and underlying mechanisms of melatonin in oxygen-glucose deprivation/reoxygenation (OGD/R)-insulted SH SY5Y cells.SH cells were cultured for OGD/R stimulation. Cell viability cytotoxicity measured by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide, lactate dehydrogenase (LDH), Hoechst 33258/propidium iodide (PI) staining assays. The mRNA levels high mobility group box-1 (HMGB1), tumor necrosis factor α (TNF-α), inducible nitric oxide synthase (iNOS)...