A5100362017- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer-related gene regulation
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Ubiquitin and proteasome pathways
- NF-κB Signaling Pathways
- Cancer Mechanisms and Therapy
- RNA Research and Splicing
- FOXO transcription factor regulation
- Mechanisms of cancer metastasis
- Cancer, Hypoxia, and Metabolism
- Ferrocene Chemistry and Applications
- Caveolin-1 and cellular processes
- Peptidase Inhibition and Analysis
- interferon and immune responses
- Cancer Genomics and Diagnostics
- Endoplasmic Reticulum Stress and Disease
- Glioma Diagnosis and Treatment
- Wnt/β-catenin signaling in development and cancer
- Ferroptosis and cancer prognosis
- Renal and related cancers
- TGF-β signaling in diseases
The First Affiliated Hospital, Sun Yat-sen University
2024-2025
Sun Yat-sen University
2016-2025
Inner Mongolia University of Science and Technology
2024-2025
Xi'an Jiaotong University
2025
Gansu Provincial Hospital
2025
Shantou University
2025
Shantou University Medical College
2025
Nanjing Medical University
2009-2024
Huazhong University of Science and Technology
2015-2024
Huizhou Central People's Hospital
2016-2024
The polycomb group protein B lymphoma Mo-MLV insertion region 1 homolog (Bmi-1) is dysregulated in various cancers, and its upregulation strongly correlates with an invasive phenotype poor prognosis patients nasopharyngeal carcinomas. However, the underlying mechanism of Bmi-1-mediated invasiveness remains unknown. In current study, we found that Bmi-1 induced epithelial-mesenchymal transition (EMT) enhanced motility human epithelial cells, whereas silencing endogenous expression reversed...
Patients with bladder cancer (BCa) clinical lymph node (LN) metastasis have an extremely poor prognosis. VEGF-C has been demonstrated to play vital roles in LN BCa. However, approximately 20% of BCa exhibits low expression, suggesting a VEGF-C–independent mechanism for Herein, we demonstrate that cell–secreted exosome-mediated lymphangiogenesis promoted manner. We identified exosomal long noncoding RNA (lncRNA), termed metastasis-associated transcript 2 (LNMAT2), stimulated human lymphatic...
Abstract Background Although both circular RNAs (circRNAs) and autophagy are associated with the function of breast cancer (BC), whether circRNAs regulate BC progression via remains unknown. In this study, we aim to explore regulatory mechanisms clinical significance autophagy-associated in BC. Methods Autophagy were screened by deep sequencing validated qRT-PCR tissues high- low- autophagic level. The biological assessed plate colony formation, cell viability, transwells, flow cytometry...
The IKKβ and NEMO/IKKγ subunits of the NF-κB-activating signalsome complex are known to be essential for activating NF-κB by inflammatory other stress-like stimuli. However, IKKα subunit is believed dispensable latter responses instead functions as an <i>in vivo</i>mediator novel NF-κB-dependent -independent functions. In contrast this generally accepted view IKKα's physiological functions, we demonstrate in mouse embryonic fibroblasts (MEFs) that, akin NEMO/IKKγ, also a global regulator...
Astrocyte elevated gene-1 (AEG-1), upregulated in various types of human cancers, has been reported to be associated with the carcinogenesis cancer. However, functional significance AEG-1 esophageal squamous cell carcinoma (ESCC) remains unknown. In present study, we showed expression was markedly cancer lines and surgical ESCC specimens at both transcriptional translational levels. Immunohistochemical analysis revealed that 80 168 (47.6%) paraffin-embedded archival exhibited high levels...
FOXO transcription factors are key tumor suppressors in mammalian cells. Until now, suppression of FOXOs cancer cells was thought to be mainly due activation multiple onco-kinases by a phosphorylation-ubiquitylation-mediated cascade. Therefore, it speculated that inhibition proteins would naturally occur through step post-translational process. However, whether may downregulate protein via an alternative regulatory mechanism is unclear. In the current study, we report expression miR-96...
Abstract Purpose: The present study was to investigate the clinical significance of sphingosine kinase 1 (SPHK1), an oncoenzyme, in development and progression gastric cancer. Experimental Design: mRNA protein levels SPHK1 expression normal epithelial cells, cancer cell lines, paired lesions adjacent noncancerous tissues were examined using reverse transcription-PCR Western blotting. Immunohistochemistry employed analyze 175 clinicopathologically characterized cases. Statistical analyses...
The strength and duration of NF-κB signaling are tightly controlled by multiple negative feedback mechanisms. However, in cancer cells, these loops overridden through unclear mechanisms to sustain oncogenic activation signaling. Previously, we demonstrated that overexpression miR-30e* directly represses IκBα expression leads hyperactivation NF-κB. Here, report miR-182 was overexpressed a different set gliomas with relatively lower suppressed cylindromatosis (CYLD), an regulator. This...
Abstract Purpose: The present study was to examine the effect of sphingosine kinase-1 (SPHK1) on chemotherapeutics-induced apoptosis in non–small cell lung cancer (NSCLC) cells, which is relatively insensitive chemotherapy, and its clinical significance NSCLC progression. Experimental Design: correlation SPHK1 expression features analyzed 218 paraffin-embedded archived specimens by immunohistochemical analysis. induced chemotherapeutics examined both vitro vivo, using Annexin V staining...
It is increasingly recognized that the mechanisms underlying ischemic cell death are sexually dimorphic. Stroke-induced in males initiated by mitochondrial release of apoptosis-inducing factor, resulting caspase-independent death. In contrast, females primarily triggered cytochrome c with subsequent caspase activation. Because X-linked inhibitor apoptosis (XIAP) primary endogenous caspases, its regulation may play a unique role response to injury females. XIAP mRNA levels were higher at...
Abstract Cancer chemoresistance and metastasis are tightly associated features. However, whether they share common molecular mechanisms thus can be targeted with one strategy remain unclear in non-small cell lung cancer (NSCLC). Here, we report that high levels of microRNA-128-3p (miR-128-3p) is key to concomitant development residual NSCLC cells having survived repeated chemotherapy correlates chemoresistance, aggressiveness poor prognosis patients. Mechanistically, miR-128-3p induces...
Abstract The poor prognosis of malignant gliomas is largely attributed to their highly invasive nature. molecular mechanism underlying the invasiveness glioma cells, however, remains be elucidated. present study found that astrocyte elevated gene-1 (AEG-1) was upregulated in human cell lines and tissues compared with normal astrocytes brain tissues. AEG-1 265 296 (89.5%) sections, expression level significantly correlated clinicopathologic stages gliomas. Ectopic or short hairpin RNA...
The DNA damage response (DDR) encompasses multi-step processes by which cells evolve to sense damage, transduce the signal and initiate repair of damaged DNA. Ataxia Telangiectasia Mutated (ATM) Kinase, functions as primary sensor transducer signal, has been demonstrated play an important role in DDR cancer prevention. Hence, understanding molecular mechanisms underlying regulation ATM received much attention. Here, we found that miR-18a was upregulated both cell lines patients' tissue...
Sp1, the first identified transcription factor, has been reported to be associated with development and progression of various human cancer types. However, clinical significance biological role Sp1 in glioma are less well understood. In this study, we found that expression was markedly elevated cell lines tissues. Immunohistochemistry analysis revealed vast majority 222 paraffin-embedded archival specimens tested displayed positive expression, 58.6% exhibited high-level expression....
Abstract Purpose: Golgi phosphoprotein 3 (GOLPH3) has been reported to be involved in various biologic processes. The clinical significance and role of GOLPH3 breast cancer, however, remains unknown. Experimental Design: Expression normal cells, cancer 6-paired adjacent noncancerous tissues were quantified using real-time PCR Western blotting. protein expression was analyzed 258 archived, paraffin-embedded samples immunohistochemistry. cell proliferation tumorigenicity explored vitro vivo....
Constitutive activation of NF-κB is a frequent event in human cancers, playing important roles cancer development and progression. In nontransformed cells, tightly controlled by IκBs. IκBs bind the cytoplasm, preventing it from translocating to nucleus modulate gene expression. Stimuli that activate signaling trigger IκB degradation, enabling nuclear translocation NF-κB. Among genes regulated are those encoding IκBs, providing negative feedback loop limits activity. How transformed cells...
Abstract Background Anti-angiogenic therapy represents a promising strategy for non-small-cell lung cancer (NSCLC) but its application in squamous cell carcinoma (SQC) is limited due to the high-risk adverse effects. Accumulating evidence indicates that long noncoding RNAs (lncRNAs) mediate tumor progression by participating regulation of VEGF NSCLC, which might guide development new antiangiogenic strategies. Methods Differential lncRNA expression SQC was analyzed AE-meta and TCGA datasets,...
Abstract Purpose: Lipid rafts, specialized domains in cell membranes, function as physical platforms for various molecules to coordinate a variety of signal transduction processes. Flotinllin-1 (FLOT1), marker lipid is involved the progression cancer, but precise mechanism remains unclear. The aim present study was examine role FLOT1 on tumorigenesis breast cancer cells and its clinical significance disease. Experimental Design: expression analyzed 212 paraffin-embedded, archived samples by...
Accumulating evidence has shown that miRNAs are aberrantly expressed in human gastric cancer and crucial to tumorigenesis.Herein, we identified the role of miR-148a cell proliferation.miR-148a knockdown inhibited proliferation lines.Conversely, overexpression promoted cycle progression.p27, a key inhibitor cycle, was verified as target miR-148a, indicating might downregulate p27 expression promote proliferation.Moreover, confirmed frequently dramatically downregulated advanced tissues,...
The Wnt/β-catenin pathway is constitutively active and promotes multiple tumor processes, including breast cancer metastasis. However, the underlying mechanism by which activated in metastasis remains unclear. Inhibition of Wnt antagonists important for signaling activation, post-transcriptional regulation these microRNAs (miRNAs) might be a possible activation. Regulation nuclear pre-mRNA domain-containing 1A (RPRD1A) known inhibitor cell growth activity, but function regulatory RPRD1A have...