A5003905939- Bladder and Urothelial Cancer Treatments
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Urinary and Genital Oncology Studies
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Immune cells in cancer
- Immune Response and Inflammation
- RNA and protein synthesis mechanisms
- MicroRNA in disease regulation
- Prostate Cancer Treatment and Research
- Urological Disorders and Treatments
- Ferroptosis and cancer prognosis
- Radiomics and Machine Learning in Medical Imaging
- Immunotherapy and Immune Responses
- Cancer, Lipids, and Metabolism
- Renal cell carcinoma treatment
- Fibroblast Growth Factor Research
- Prostate Cancer Diagnosis and Treatment
- Mycobacterium research and diagnosis
- Colorectal Cancer Screening and Detection
- Kidney Stones and Urolithiasis Treatments
- Cancer Cells and Metastasis
Sun Yat-sen Memorial Hospital
2016-2025
Sun Yat-sen University
2016-2025
State Key Laboratory of Oncology in South China
2018-2024
Fujian Medical University
2024
Union Hospital
2024
Guangdong Provincial Center for Disease Control and Prevention
2020-2024
Sun Yat-sen University Cancer Center
2022-2023
Key Laboratory of Guangdong Province
2020-2023
University of Colorado Denver
2022
University of Colorado Cancer Center
2022
Purpose: To develop and validate a radiomics nomogram for the preoperative prediction of lymph node (LN) metastasis in bladder cancer.Experimental Design: A total 118 eligible cancer patients were divided into training set (n = 80) validation 38). Radiomics features extracted from arterial-phase CT images each patient. signature was then constructed with least absolute shrinkage selection operator algorithm set. Combined independent risk factors, built multivariate logistic regression model....
Abstract Tumor-associated macrophages (TAMs) are the most abundant inflammatory infiltrates in tumor microenvironment and contribute to lymph node (LN) metastasis. However, precise mechanisms of TAMs-induced LN metastasis remain largely unknown. Herein, we identify a long noncoding RNA, termed Lymph Node Metastasis Associated Transcript 1 ( LNMAT1 ), which is upregulated LN-positive bladder cancer associated with prognosis. Through gain loss function approaches, find that promotes...
Patients with bladder cancer (BCa) clinical lymph node (LN) metastasis have an extremely poor prognosis. VEGF-C has been demonstrated to play vital roles in LN BCa. However, approximately 20% of BCa exhibits low expression, suggesting a VEGF-C–independent mechanism for Herein, we demonstrate that cell–secreted exosome-mediated lymphangiogenesis promoted manner. We identified exosomal long noncoding RNA (lncRNA), termed metastasis-associated transcript 2 (LNMAT2), stimulated human lymphatic...
Abstract Purpose: Chemoresistance and tumor relapse are the leading cause of deaths in bladder cancer patients. Bladder stem cells (BCSCs) have been reported to contribute these pathologic properties. However, molecular mechanisms underlying their self-renewal chemoresistance remain largely unknown. In current study, a novel lncRNA termed Low expressed Cancer Stem (lnc-LBCS) has identified explored BCSCs. Experimental Design: Firstly, we establish BCSCs model explore BCSCs-associated lncRNAs...
Castration-resistant prostate cancer (CRPC) that occurs after the failure of androgen deprivation therapy is leading cause deaths in patients. Thus, there an obvious and urgent need to fully understand mechanism CRPC discover novel therapeutic targets. Long noncoding RNAs (lncRNAs) are crucial regulators many human cancers, yet their potential roles molecular mechanisms poorly understood. In this study, we discovered lncRNA HOXD-AS1 highly expressed cells correlated closely with Gleason...
BackgroundAlterations in the brain cortical structures of patients with chronic kidney disease (CKD) have been reported; however, cause has not determined yet. Herein, we used Mendelian randomization (MR) to reveal causal effect damage on structure.MethodsGenome-wide association studies summary data estimated glomerular filtration rate (eGFR) 480,698 participants from CKDGen Consortium were identify genetically predicted eGFR. Data 567,460 individuals assess CKD; 302,687 UK Biobank evaluate...
BACKGROUNDCurrent methods for the detection and surveillance of bladder cancer (BCa) are often invasive and/or possess suboptimal sensitivity specificity, especially in early-stage, minimal, residual tumors.METHODSWe developed an efficient method, termed utMeMA, urine tumor DNA methylation at multiple genomic regions by MassARRAY. We identified BCa-specific markers combined analyses cohorts from Sun Yat-sen Memorial Hospital (SYSMH), The Cancer Genome Atlas (TCGA), Gene Expression Omnibus...
The prognosis for bladder cancer patients with lymph node (LN) metastasis is dismal and only minimally improved by current treatment modalities. Elucidation of the molecular mechanisms that underlie LN may provide clinical therapeutic strategies LN-metastatic cancer. Here, we report a long noncoding RNA LINC00958, which have termed cancer-associated transcript 2 (BLACAT2), was markedly upregulated in correlated metastasis. Overexpression BLACAT2 promoted lymphangiogenesis lymphatic both...
Abstract Background The association between depression and prostate carcinogenesis has been reported in observational studies but the causality from on cancer (PCa) remained unknown. We aimed to assess causal effect of PCa using two‐sample Mendelian randomization (MR) method. Methods Two sets genetics instruments were used for analysis, derived publicly available genetic summary data. One was 44 single‐nucleotide polymorphisms (SNPs) robustly associated with major depressive disorder (MDD)...
Knowledge of somatic mutation accumulation in normal cells, which is essential for understanding cancer development and evolution, remains largely lacking. In this study, we investigated clonal events morphologically human urothelium (MNU; epithelium lining the bladder ureter) identified macroscopic expansions. Aristolochic acid (AA), a natural herb-derived compound, was major mutagenic driving factor MNU. AA drastically accelerates enhances expansion. Mutations MNU were widely observed...
Circular RNAs (circRNAs) have been considered to mediate occurrence and development of human cancers, generally acting as microRNA (miRNA) sponges regulate downstream genes expression. However, the aberrant expression profile dysfunction circRNAs in bladder cancer remain be investigated. The present study aims elucidate potential role molecular mechanism circACVR2A regulating proliferation metastasis cancer. (hsa_circ_0001073) was identified by RNA-sequencing validated quantitative real-time...
Small ubiquitin-like modifier (SUMO) binding (termed SUMOylation) emerged as the inducer for sorting of bioactive molecules into extracellular vesicles (EVs), triggering lymphangiogenesis and further driving tumor lymph node (LN) metastasis, but precise mechanisms remain largely unclear. Here, we show that bladder cancer (BCa) cell-secreted EVs mediated intercellular communication with human lymphatic endothelial cells (HLECs) through transmission long noncoding RNA ELNAT1 promoted LN...
Abstract Epitranscriptomic RNA modifications constitute a critical gene regulatory component that can affect cancer progression. Among these, the N4-acetylcytidine (ac4C) modification, which is mediated by ac4C writer N-acetyltransferase 10 (NAT10), regulates stabilization of mRNA. Here, we identified modification induced upon cisplatin treatment and correlates with chemoresistance in bladder cancer. Both vitro vivo, NAT10 promoted cells enhancing DNA damage repair (DDR). Mechanistically,...
With the rapid development of technology, artificial intelligence (AI) has been widely used in diagnosis and prognosis prediction a variety diseases, including prostate cancer. Facts have proved that AI broad prospects accurate treatment cancer.This study mainly summarizes research on application field cancer through bibliometric analysis explores possible future hotspots.The articles reviews regarding between 1999 2020 were selected from Web Science Core Collection August 23, 2021....
Abstract Background Lymphatic metastasis has been associated with poor prognosis in bladder cancer patients limited therapeutic options. Emerging evidence shows that heat shock factor 1 (HSF1) drives diversified transcriptome to promote tumor growth and serves as a promising target. However, the roles of HSF1 lymphatic remain largely unknown. Herein, we aimed illustrate clinical mechanisms explore its potential. Methods We screened most relevant gene among overexpressed factors (HSFs)...
As a key step of tumor lymphatic metastasis, lymphangiogenesis is regulated by VEGFC-VEGFR3 signaling pathway mediated immune cells, mainly macrophages, in the microenvironment. However, little known whether associated neutrophils are involved lymphangiogenesis. Here, it found that TANs infiltration increased LN-metastatic BCa and with poor prognosis. Neutrophil depletion results significant reduction popliteal LN metastasis Mechanistically, transcription factor ETV4 enhances cells-derived...
Cancer-associated fibroblasts (CAFs) exhibit considerable heterogeneity in advanced cancers; however, the functional annotation and mechanism of CAFs early-stage cancers remain elusive. Utilizing single-cell RNA sequencing spatial transcriptomic, we identify a previously unknown PDGFRα+ITGA11+ CAF subset bladder cancer (BCa). Multicenter clinical analysis 910-case cohort confirms that are associated with lymphovascular invasion (LVI) poor prognosis BCa. These facilitate LVI lymph node (LN)...
Increasing evidence has suggested that dysregulation of certain microRNAs (miRNAs) may contribute to tumorigenesis. microRNA-125b (miR-125b) was implicated have close relationship with cell proliferation and differentiation, downregulation miR-125b observed in various types cancers. However, the biological function bladder tumorigenesis is still unknown. In our study, we showed expression significantly decreased cancer tissues four lines. Moreover, could suppress cells form colonies vitro...
No AccessJournal of UrologyInvestigative Urology1 Mar 2009MicroRNA-143 as a Tumor Suppressor for Bladder Canceris companion ofIntravesical Mycobacterial Cell Wall-DNA Complex in the Treatment Carcinoma In Situ After Standard Intravesical Therapy Has FailedA Double-Blind Randomized Crossover Study Oral Thalidomide Versus Placebo Androgen Dependent Prostate Cancer Treated With Intermittent Ablation Tianxin Lin, Wen Dong, Jian Huang, Qiuhui Pan, Xinlan Fan, Caixia Zhang, and Li Huang LinTianxin...
Increasing evidence has revealed that circular RNAs (circRNAs) play crucial roles in cancer biology. However, the role and underlying regulatory mechanisms of circFNDC3B bladder (BC) remain unknown. A cell invasion model was established by repeated transwell assays, invasion-related circRNAs BC were identified through an model. The expression detected 82 tissues lines quantitative real-time PCR. Functional assays performed to evaluate effects on proliferation, migration vitro-, tumorigenesis...
Abstract Background Circular RNAs (circRNAs) represent a subclass of regulatory that have been shown to significant roles in cancer progression. However, the biological functions circRNAs bladder (BCa) are largely unknown. Methods Cell invasion models were established, and invasion-related detected by qPCR. Using above method, circ- ZKSCAN1 was picked out for further study. Circ- expression survival analyses performed through The curves generated Kaplan-Meier log-rank test used assess...
BackgroundPreoperative lymph node (LN) status is important for the treatment of bladder cancer (BCa). However, a proportion patients are at high risk inaccurate clinical nodal staging by current methods. Here, we report an accurate magnetic resonance imaging (MRI)-based radiomics signature individual preoperative prediction LN metastasis in BCa.MethodsIn total, 103 eligible BCa were divided into training set (n = 69) and validation 34). And 718 features extracted from cancerous volumes...