A5041967108- RNA modifications and cancer
- Cytokine Signaling Pathways and Interactions
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Pharmacological Effects of Natural Compounds
- Cancer, Hypoxia, and Metabolism
- Flavonoids in Medical Research
- Phytochemistry and Biological Activities
- Fibroblast Growth Factor Research
- Natural product bioactivities and synthesis
- Cancer Cells and Metastasis
- interferon and immune responses
- Kruppel-like factors research
- Chromatin Remodeling and Cancer
- Hippo pathway signaling and YAP/TAZ
- Cancer Immunotherapy and Biomarkers
- DNA Repair Mechanisms
- Oral and gingival health research
- Abdominal Surgery and Complications
- NF-κB Signaling Pathways
- Phytochemical Studies and Bioactivities
- Protein Degradation and Inhibitors
- Selenium in Biological Systems
- Traditional Chinese Medicine Analysis
The First Affiliated Hospital, Sun Yat-sen University
2017-2024
Sun Yat-sen University
2017-2024
Guangzhou University of Chinese Medicine
2014-2019
China National Pharmaceutical Group Corporation (China)
2015
Lingnan University
2014
Abstract Background Lymphatic metastasis has been associated with poor prognosis in bladder cancer patients limited therapeutic options. Emerging evidence shows that heat shock factor 1 (HSF1) drives diversified transcriptome to promote tumor growth and serves as a promising target. However, the roles of HSF1 lymphatic remain largely unknown. Herein, we aimed illustrate clinical mechanisms explore its potential. Methods We screened most relevant gene among overexpressed factors (HSFs)...
Abstract Background N6‐methyladenosine (m6A) methylation, a well‐known modification with new epigenetic functions, has been reported to participate in gastric cancer (GC) tumourigenesis, providing novel insights into the molecular pathogenesis of GC. However, involvement Wilms’ tumour 1‐associated protein (WTAP), key component m6A GC progression is controversial. Here, we investigated biological role and underlying mechanism WTAP Methods We determined expression using tissue microarrays The...
The mechanistic action of bromodomain-containing protein 4 (BRD4) in cancer motility, including epithelial-mesenchymal transition (EMT), remains largely undefined. We found that targeted inhibition BRD4 reduces migration, invasion, vivo growth patient-derived xenograft (PDX), and lung colonization breast (BC) cells. Inhibition rapidly decreases the expression Snail, a powerful EMT transcription factor (EMT-TF), via diminishing its stability transcription. Protein kinase D1 (PRKD1) is...
MicroRNAs have been proposed as novel biomarkers for the diagnosis and treatment of many types cancer. The levels five candidate microRNAs (miRNAs) (miR-99a-5p, miR-31-5p, miR-138-5p, miR-21-5p, miR-375-3p) in sera from oral cancer patients paired tumor normal tissues were detected by real-time qPCR. diagnostic power these miRNAs was analyzed receiver operating characteristic (ROC) curves. Patient-derived xenograft (PDX) models established utilized to verify potential therapeutic effect...
Abstract Osteosarcoma is the most common primary bone tumor in children and adolescents. Many patients with osteosarcoma always develop drug resistance to current chemotherapy regimens, which induces a poor prognosis. And cancer stem cells (CSCs) have been reported possess properties self-renew maintain phenotype of tumor, may lead clinical treatment failure. Thus, it an urgent task several potentially useful therapeutic agents, could target CSCs osteosarcoma. This study aims clarify vitro...
The extracellular matrix (ECM) has been demonstrated to be dysregulated and crucial for malignant progression in gastric cancer (GC), but the mechanism is not well understood. Here, that discoidin domain receptor 1 (DDR1), a principal ECM receptor, recognized as key driver of GC reported. Mechanistically, DDR1 directly interacts with PAS hypoxia-inducible factor-1α (HIF-1α), suppresses its ubiquitination subsequently strengthens transcriptional regulation angiogenesis. Additionally,...
Abstract Background The effectiveness of ketogenic diet (KD) in ameliorating fatty liver has been established, although its mechanism is under investigation. Fibroblast growth factor 21 (FGF21) positively regulates obesity-associated metabolic disorders and elevated by KD. FGF21 conventionally initiates intracellular signaling via receptor β-klotho (KLB). However, the mechanistic role FGF21-KLB for KD-ameliorated remains unknown. This study aimed to delineate critical ameliorative effects KD...
Abstract CDK4/6 inhibitors show promising antitumor activity in a variety of solid tumors; however, their role head and neck squamous cell carcinoma (HNSCC) requires further investigation. The senescence-associated secretory phenotype (SASP) induced by has dual effects on cancer treatment. need to address the SASP is serious challenge clinical application inhibitors. We investigated whether metformin can act as senostatic drug modulate enhance anticancer efficacy HNSCC. In this study,...
In rheumatoid arthritis (RA), imbalanced T cells subsets play a critical role in sustaining chronic inflammatory responses the synovium. Naïve RA patients undergo maldifferentiation, including an increase effector Th1/Th17 lineage and reduction regulatory (Treg) cells. Upon stimulation, naïve CD4+CD45RO− from exhibited insufficient expression of Foxp3, which induced deficiency Tregs production imbalance Treg/Th17 differentiation. Further mechanistic study indicated that failed to produce...
In the process of epithelial-mesenchymal transition (EMT), epithelial cancer cells transdifferentiate into mesenchymal-like with high motility and aggressiveness, resulting in spread tumor cells. Immune inflammation microenvironment are driving factors EMT, but few studies have explored core targets interaction between EMT immune We analyzed thousands cases gastric tissue specimens TCGA, CPTAC, GTEx analyzing QPCR IHC data 56 patients SYSU Gastric Cancer Research Center. It was known that...
Signal transducer and activator of transcription 3 (STAT3) is an oncogene constitutively activated in hepatocellular carcinoma (HCC) cells HCC cancer stem (CSCs). Constitutively STAT3 plays a pivotal role holding stemness CSCs, which are essential for hepatoma initiation, relapse, metastasis drug resistance. Therefore, has been validated as novel anti-cancer target the strategies targeting CSCs may bring new hopes to therapy. This study aimed isolate identify small-molecule signaling...
Anlotinib, a novel multitarget tyrosine kinase inhibitor, has shown promising results in the management of various carcinomas. This study aimed to investigate antitumor activity anlotinib oral squamous cell carcinoma (OSCC) and underlying molecular mechanism. A retrospective clinical revealed that improved median progression-free survival (mPFS) overall (mOS) patients with recurrent metastatic (R/M) OSCC, respectively. Functional studies markedly inhibited vitro proliferation OSCC cells...
Background The efficacy of docetaxel-based chemotherapy is limited by the development drug resistance. Recent studies demonstrated anti-programmed death-1 (PD-1)/programmed cell death ligand-1 (PD-L1) immunotherapies in metastatic prostate cancer. ataxia telangiectasia mutation (ATM) protein plays a crucial role maintaining genome stability and function mitosis. Here, we aimed to determine whether PD-1/PD-L1 signaling contributes resistance DTX elucidate mechanism underlying DTX-induced...
We showed that microtubule-associated tumor suppressor gene (MTUS1/ATIP) downregulation correlated with poor survival in head and neck squamous cell carcinoma (HNSCC) patients MTUS1/ATIP1 was the most abundant isoform HNSCC tissue. However, location function of have remain unclear. In this study, we confirmed inhibited proliferation, growth metastasis cell- patient-derived xenograft models
Constitutive activation of the signal transducer and activator transcription 3 ( STAT 3) or nuclear factor‐κB NF ‐κB) pathway occurs frequently in cancer cells contributes to oncogenesis. The Janus kinase 2 JAK 2) IκB IKK ) are key events ‐κB signaling, respectively. We have identified 2‐methoxystypandrone (2‐ MS from a traditional Chinese medicinal herb Polygonum cuspidatum as novel dual inhibitor . 2‐ inhibits both interleukin‐6‐induced constitutively‐activated 3, well tumor necrosis...
OS (Osteosarcoma) is the most common malignant tumor in adolescents, and lung metastasis limits its therapeutic outcome. The present study aimed to establish a highly metastatic human cell line directly from metastases characterize biological functions. In this study, epithelioid cells with large nucleo-cytoplasmic ratio abundant organelles were obtained by tissue mass adherent repeated digestion method named ZOSL-1 cells. had potential proliferate vitro doubling time of 39.28 ± 3.04 h...
The oncogene, malignant T-cell-amplified sequence 1 (MCTS1), has been found to be highly expressed in a variety of cancer cell lines. It shown involved cycle progression and confer growth advantage for lymphomas breast cancer. Nevertheless, the role MCTS1 contributing development oral remains elusive.We analyzed gene expression profiles normal keratinocytes cancerous cells. Cellular proliferation, invasion, migration experiments were performed detect effect on biological evolution vitro...
Head and neck squamous cell carcinoma (HNSCC) has been recognized as the seventh most prevalent malignant tumor globally. It is a neoplasm that arises from mucosal epithelium of head region. In our previous research, we have demonstrated MTUS1/ATIP1 exhibits anti-cancer properties in HNSCC. Nevertheless, underlying mechanism responsible for reduction expression not investigated. HNSCC adjacent normal tissues were collected examined using m6A MeRIP-seq, qRT-PCR, IHC to investigate...