A5005506987- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Gout, Hyperuricemia, Uric Acid
- Hepatitis C virus research
- Autoimmune and Inflammatory Disorders Research
- Musculoskeletal synovial abnormalities and treatments
- Hepatitis B Virus Studies
- Spondyloarthritis Studies and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Immunodeficiency and Autoimmune Disorders
- Chronic Lymphocytic Leukemia Research
- Inflammatory Myopathies and Dermatomyositis
- Systemic Sclerosis and Related Diseases
- Salivary Gland Disorders and Functions
- Bone Metabolism and Diseases
- Biosimilars and Bioanalytical Methods
- Lymphoma Diagnosis and Treatment
- Cell Adhesion Molecules Research
- Cytokine Signaling Pathways and Interactions
- HER2/EGFR in Cancer Research
- Eosinophilic Disorders and Syndromes
- Osteoarthritis Treatment and Mechanisms
- Liver Disease Diagnosis and Treatment
- Peroxisome Proliferator-Activated Receptors
- IgG4-Related and Inflammatory Diseases
Sun Yat-sen University
2016-2025
Sun Yat-sen Memorial Hospital
2016-2025
Xuzhou Medical College
2025
Second People’s Hospital of Huai’an
2025
First Affiliated Hospital of Jinan University
2025
University Medical Center Freiburg
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Foundation for Women’s Wellness
2015
HZ University of Applied Sciences
2015
X-Fab (Germany)
2015
Anti-malarial drug artesunate can suppress inflammation and prevent cartilage bone destruction in collagen-induced arthritis model rats—suggesting it may be a potent for rheumatoid (RA) therapy. We aimed to investigate its effect on the invasive property of fibroblast-like synoviocytes (FLS) from patients with RA. Synovial tissues were obtained by closed needle biopsy active RA patients, FLS isolated cultured vitro. RA-FLS treated at various concentrations, while methotrexate or...
Aim To investigate the impact of short-course tocilizumab (TCZ) on hepatitis B virus (HBV) reactivation in rheumatoid arthritis (RA) patients. Methods RA patients with moderate to high disease activity, at least one feature poor prognosis and inadequate response conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) were recruited. Three consecutive doses intravenous TCZ given combined csDMARDs. Liver function HBV infection status evaluated baseline, weeks 4, 8 12. Results...
To quantify inflammatory changes in synovial membranes from orthopaedic "non-inflammatory" arthropathies (Orth. A).Synovial patients with femur fracture, avascular necrosis of the femur, plica syndrome, and meniscus and/or ligament injury (n = 23); rheumatoid arthritis 28); osteoarthritis (OA; n 25); normal controls 10) were assessed by light microscopy, a histological synovitis score, immunostaining for CD3, CD20, CD38, CD68, Ki-67 von Willebrand factor, an immunohistochemical inflammation...
Objective . To explore the correlation between matrix metalloproteinase- (MMP-) 3 and histological synovitis in rheumatoid arthritis (RA). Methods Serum MMP-3 of 62 patients with active RA was detected by ELISA. Serial synovial tissue sections from all patients, 13 osteoarthritis, 10 orthopedic arthropathies were stained hematoxylin eosin immunohistochemically for MMP-3, CD3, CD20, CD38, CD68, CD15. Results The percentage lining MMP3+ cells significantly higher especially high grade it...
Abstract Background The link between body mass index (BMI) and disease characteristics in rheumatoid arthritis (RA) remains controversial. Body composition (BC) has been more frequently recommended to be used instead of BMI for accurate assessment. Our study aimed investigate the BC RA patients their associations with characteristics. Methods was assessed consecutive Chinese control subjects by bioelectric impedance analysis. Overfat defined fat percentage (BF%) as ≥25% men ≥35% women....
Our objective was to evaluate the feasibility, safety, and efficacy of intravenous (IV) infusion allogenic mesenchymal stem cells (MSCs) in ankylosing spondylitis (AS) patients who are refractory or cannot tolerate side effects nonsteroidal anti-inflammatory drugs (NSAIDs). AS enrolled this study received four IV infusions MSCs on days 0, 7, 14, 21. The percentage ASAS20 responders (the primary endpoint) at fourth week mean response duration secondary were used assess treatment MSC...
The epidemiological characteristics of Sjögren syndrome (SS) are significantly varied in different countries. We conducted the present study to survey primary SS China. recruited 483 patients from 16 Chinese medical centers nationwide January 2009 November 2011 and assessed salivary lacrimal gland dysfunction, organ involvement, autoimmunity these patients. cohort included 456 women 27 men (ratio, 17:1; mean age at onset, 42 ± 11 years; median diagnosis, 49 range, 41–56 years). Male showed a...
Objectives Previous studies have compared mycophenolate mofetil and azathioprine as maintenance therapy for lupus nephritis (LN). Leflunomide is an immunosuppressant widely used in the treatment of rheumatoid arthritis. The aim this investigator-initiated study was to compare efficacy safety leflunomide versus LN. Methods 270 adult patients with biopsy-confirmed active LN from 7 Chinese Rheumatology Centres were enrolled. All received induction 6–9 months intravenous cyclophosphamide plus...
In rheumatoid arthritis (RA), imbalanced T cells subsets play a critical role in sustaining chronic inflammatory responses the synovium. Naïve RA patients undergo maldifferentiation, including an increase effector Th1/Th17 lineage and reduction regulatory (Treg) cells. Upon stimulation, naïve CD4+CD45RO− from exhibited insufficient expression of Foxp3, which induced deficiency Tregs production imbalance Treg/Th17 differentiation. Further mechanistic study indicated that failed to produce...
Elevated cell-free DNA (cfDNA) levels in the plasma and synovial fluid of rheumatoid arthritis (RA) patients are proposed to be pathologically relevant. However, direct evidence support this perception is lacking, molecular feature cfDNA molecules with assumed pathological function not well characterized. Here, we confirm remarkably increased total cfDNAs a large cohort compared counterparts osteoarthritis, demonstrate potent inflammatogenic effects RA on both human monocyte cell line...
Synovium fibroblast-like synoviocytes (FLSs) are important participants in the pathogenesis of synovitis and joint destruction rheumatoid arthritis (RA). Pyroptosis is a pro-inflammatory cell lytic programmed death mechanism mediated by gasdermin (GSDM) family proteins. In this study, we demonstrated increased expression GSDME levels GSDME-mediated pyroptosis RA synovial tissues. vitro, stimulation with TNF-α plus hypoxia mimicking inflammatory hypoxic environment synovium induced RA-FLSs...
Objective: To investigate the characteristics of hand dysfunction and its associated factors in patients with rheumatoid arthritis (RA). Methods: A cross-sectional study. Patients RA were recruited from January 2019 to April 2024 at Department Rheumatology Immunology, Sun Yat-Sen Memorial Hospital, University. Demographic clinical data collected, including age, gender, active smoking, disease duration, time morning stiffness, factor anti-cyclic citrullinated peptide antibody, activity,...
To investigate the effects of thalidomide in preventing disease relapse with 'zero' glucocorticoids (GCs) usage IgG4-related (IgG4-RD). This was a multicentre, randomised, double-blinded, placebo-controlled study, which eligible patients active status were randomised into 2 groups (group 1: GCs+Thalidomide; group 2: GCs+Placebo) at 1:1 ratio. The primary outcome this trial rate month 12, whereas secondary outcomes remission 12 and incidence adverse events (AEs). A total 60 57...
Background and Objectives: Sarcopenia is a notable comorbidity of rheumatoid arthritis (RA), affecting about one third patients. However, the characteristic muscle function its association with RA disease remains unknown. Materials Methods: This cross-sectional study collected clinical data from real-world Chinese cohort. was defined as both myopenia low (LMF). Myopenia appendicular skeletal mass index (ASMI) < 7.0 kg/m2 in men <5.7 women. LMF strength (LMS, hand grip 28 kg <18...
Early menopause (EM, age ≤ 45 years) is associated with an increased risk of developing rheumatoid arthritis (RA). We aimed to investigate its impact on disease characteristics in RA patients. This cross-sectional study included natural post-menopausal patients from observational cohort recruited between January 2015 and October 2023. Demographic clinical data were collected. Patients divided into EM usual (UM, > groups. Patients-reported outcomes (PROs, patient global assessment activity...