A5042081356- Systemic Lupus Erythematosus Research
- Vasculitis and related conditions
- Atherosclerosis and Cardiovascular Diseases
- Rheumatoid Arthritis Research and Therapies
- Renal Diseases and Glomerulopathies
- Systemic Sclerosis and Related Diseases
- Monoclonal and Polyclonal Antibodies Research
- Platelet Disorders and Treatments
- Autoimmune and Inflammatory Disorders Research
- Eosinophilic Disorders and Syndromes
- T-cell and B-cell Immunology
- Ocular Diseases and Behçet’s Syndrome
- Cell Adhesion Molecules Research
- Venous Thromboembolism Diagnosis and Management
- Liver Diseases and Immunity
- Urticaria and Related Conditions
- Galectins and Cancer Biology
- Renal and Vascular Pathologies
- Inflammasome and immune disorders
- Blood disorders and treatments
- Sarcoidosis and Beryllium Toxicity Research
- Salivary Gland Disorders and Functions
- Diabetes and associated disorders
- Otitis Media and Relapsing Polychondritis
- Spondyloarthritis Studies and Treatments
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Peking Union Medical College Hospital
2016-2025
National Clinical Research Center for Digestive Diseases
2020-2025
Ministry of Education of the People's Republic of China
2015-2025
National Clinical Research
2021-2025
Academy of Medical Sciences
2008-2025
Ministry of Science
2020-2024
Leiden University Medical Center
2024
AstraZeneca (United States)
2023
Guang’anmen Hospital
2022
Since the publication of European League Against Rheumatism (EULAR) recommendations for management large vessel vasculitis (LVV) in 2009, several relevant randomised clinical trials and cohort analyses have been published, which potential to change care therefore supporting need update original recommendations.Using EULAR standardised operating procedures EULAR-endorsed recommendations, task force undertook a systematic literature review sought opinion from 20 experts 13 countries. We...
To characterize the clinical features of IgG4-related disease (IgG4-RD) in China.A prospective cohort study IgG4-RD was carried out Peking Union Medical College Hospital between 2011 and 2013. Patients with newly diagnosed were enrolled.A total 118 patients enrolled, including 82 males 36 females, aged 53.1 (s.d. 13.6) years. The most common symptom at onset lacrimal gland swelling (38/32.2%). A range organs involved: 77 (65.3%) had lymphadenopathy, 76 (64.4%) sialadenitis, 60 (50.8%)...
To investigate the clinical features of adult patients with hemophagocytic lymphohistiocytosis (HLH) and to explore possible risk factors for death, we retrospectively reviewed medical records 103 HLH hospitalized from 1997 2012. We analyzed underlying diseases, characteristics, 1aboratory findings, outcomes, prognostic factors. The most common cause was hematologic malignancies (n = 49), followed by infectious diseases 24) autoimmune disorders 14); 24 cases were unknown etiology. Eight had...
Rheumatoid arthritis patients are at higher risk of developing comorbidities. The main objective this study was to evaluate the prevalence major comorbidities in Chinese rheumatoid patients. We also aimed identify factors associated with these Baseline demographic, clinical characteristics and comorbidity data from RA enrolled Registry rhEumatoiD arthrITis (CREDIT) Nov 2016 August 2017 were presented compared those five other registries across world. Possible related three (cardiovascular...
Patients with systemic lupus erythematosus (SLE) suffered from an increasing risk of cardiovascular diseases. In this multi-center prospective study, we aimed to determine the association between antiphospholipid antibodies (aPLs) and future atherosclerotic disease (ASCVD) in SLE. total, 1573 SLE patients were recruited based on Chinese Treatment Research group (CSTAR) registry. aPLs profile, including anticardiolipin (aCL) IgG/IgM, anti-β2 glycoprotein I (aβ2GPI) anticoagulant (LA),...
Advances in treatment have swiftly alleviated systemic inflammation of Takayasu's arteritis (TAK), while subclinical vascular and the ensuing arterial remodeling continue to present unresolved challenges TAK. The phenotypic switching smooth muscle cells (VSMC) is regarded as first step pathology contributes remodeling. Exosomes facilitate transfer exchange proteins specific nucleic acids, thereby playing a significant role intercellular communication. Little known about modulatory serum...
Tumor necrosis factor (TNF) alpha and interleukin-17 (IL-17) are thought to be involved in the pathogenesis of Takayasu arteritis (TAK), TNF inhibitors (TNFi) recommended for treatment TAK. The present study was undertaken investigate efficacy secukinumab, an IL-17A monoclonal antibody, compared with TNFi.This a prospective, single-center, open-label cohort study. Patients active TAK who did not respond glucocorticoids combined 2 immunosuppressive agents were treated either secukinumab or...
The 2023 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) antiphospholipid syndrome (APS) classification criteria were developed with higher specificity but lower sensitivity compared the 2006 Sydney revised criteria.
Abstract Takayasu’s arteritis (TAK) is a chronic granulomatous inflammatory disease that involves aorta and its primary branches. It characterized by wall thickening, stenosis/obliteration or aneurysm formation of the involved arteries. In order to standardize diagnosis treatment TAK in China, clinical practice guideline with an evidence-based approach developed under leadership National Clinical Medical Research Center for Dermatologic Immunologic Diseases (NCRC-DID). Eleven recommendations...
We aimed to investigate the clinical characteristics of 411 Chinese Takayasu's arteritis (TAK) patients using a retrospective analysis.We retrospectively reviewed 810 medical charts with diagnosis TAK who were admitted Peking Union Medical College Hospital from 1990 2014. complete dataset finally included in analysis. The demographic data, features, angiographic patterns, and TAK-related surgical procedures collected analyzed.The median age at disease onset was 23 (18, 30) years old,...
Abstract Background High levels of circulating cell‐free DNA (cf ) have been reported in patients with inflammatory conditions. The aim the study was to investigate cf systemic lupus erythematosus ( SLE ). Materials and methods Comparative groups comprised 22 nonpregnant 36 pregnant women (test groups) 60 199 no history (control groups). plasma were quantitated by a fluorometric ds assay. Results Compared controls, median significantly higher (7.38 ng/mL vs 4.6 ng/mL, P = 0.033) (7.65 5.25...
To analyze the causes of death and related risk factors for in-patients with Takayasu arteritis (TAK) admitted to a referral center China during 1983 2014. The medical charts 12 deceased TAK patients (10 women, 2 men) were reviewed by two senior rheumatologists. demographic data, clinical manifestations, angiographic presentations, direct analyzed retrospectively. Medical records 40 (32 8 selected as controls age sex matching method from 81 who sampled isometrically 810 successively same...
Objectives To investigate both the prevalence and clinical characteristics of serositis in Chinese patients with systemic lupus erythematosus (SLE) a large cohort SLE Treatment Research group (CSTAR) database. Methods A prospective cross-sectional study was conducted based on data from CSTAR registry. Serositis defined according to 1999 revised American College Rheumatology (ACR) criteria for – that is, pleuritis/pleural effusion and/or pericarditis/pericardial detected by echocardiography,...
Background Synovial hypoxia is a hallmark of rheumatoid arthritis (RA). Photoacoustic (PA) imaging, based on the use laser-generated US, can detect oxygenation status tissue in individuals with RA. However, large studies are lacking, few investigating correlation between and disease activity. Purpose To measure synovial participants RA by using multimodal PA US imaging system to determine imaging-measured oxygen saturation (SO2) Materials Methods In this prospective observational cohort...
Thrombocytopenia, a frequent clinical manifestation in patients with APS, could be an independent predictor of recurrent thrombotic, obstetric and severe extracriteria events.This single-centre prospective study enrolled 218 consecutive diagnosed primary APS between 2010 2021. Thrombocytopenia was defined as platelet count less than 100 × 109/L.Our cohort included 74 (33.94%) thrombocytopenia 144 continuous normal count. Comparison baseline characteristics indicated that had more visceral...
To investigate the treatment efficacy and safety of baricitinib in patients with refractory Takayasu arteritis (TAK). We performed a prospective cohort study which 4 mg daily was prescribed to TAK, combined oral glucocorticoids (GCs). 10 TAK were enrolled median age 28 (IQR=22-37) years, disease duration 50 (IQR=24-65) months. The dose GCs (IQR=8.1-22.5) prednisone or equivalence dosage at baseline. At 6 months treatment, 6/10 (60%) had an overall response. During average follow-up 15.3...