A5002718933- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Statistical Methods and Bayesian Inference
- Endometriosis Research and Treatment
- Sperm and Testicular Function
- Pregnancy and Medication Impact
- Uterine Myomas and Treatments
- Asthma and respiratory diseases
- Dermatology and Skin Diseases
- Maternal and fetal healthcare
- Statistical Methods and Inference
- Reproductive Biology and Fertility
- Effects and risks of endocrine disrupting chemicals
- Bayesian Methods and Mixture Models
- Reproductive Health and Technologies
- Cerebrovascular and Carotid Artery Diseases
- Intracranial Aneurysms: Treatment and Complications
- Statistical Methods in Clinical Trials
- Assisted Reproductive Technology and Twin Pregnancy
- Air Quality and Health Impacts
- Toxic Organic Pollutants Impact
- Traumatic Brain Injury and Neurovascular Disturbances
- Food Allergy and Anaphylaxis Research
- Fatty Acid Research and Health
Second Affiliated Hospital of Fujian Medical University
2015-2025
Fujian Medical University
2015-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2025
Peking Union Medical College Hospital
2015-2025
First Affiliated Hospital of Zhengzhou University
2012-2024
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2015-2024
National Institutes of Health
2015-2024
Regeneron (United States)
2020-2024
Chengdu University of Traditional Chinese Medicine
2024
University of Pennsylvania
2006-2024
What is the relationship between body size, physical activity and semen parameters among male partners of couples attempting to become pregnant? Overweight obesity are associated with a higher prevalence low ejaculate volume, sperm concentration total count. Higher BMI impaired parameters, while increasing waist circumference (WC) also in infertile men. Data from Longitudinal Investigation Fertility Environment (LIFE) Study were utilized. The LIFE study population-based prospective cohort...
Benzophenone (BP)-type UV filters are widely used in a variety of personal care products for the protection skin and hair from irradiation. Despite estrogenic potencies BP derivatives, few studies have examined occurrence these compounds human matrices. Furthermore, associations among exposure to estrogen-dependent diseases (such as endometriosis) not been previously. In this study, we determined concentrations five 2-hydroxy-4-methoxybenzophenone (2OH-4MeO-BP), 2,4-dihydroxybenzophenone...
Thyroid diseases are inconsistently reported to increase risk for pregnancy complications. The objective of this study was complications associated with common and uncommon thyroid diseases. We analyzed singleton pregnancies (N = 223 512) from a retrospective US cohort, the Consortium on Safe Labor (2002–2008). outcomes were derived electronic medical records. Multivariable logistic regression generalized estimating equations estimated adjusted odds ratios (ORs) 99% confidence intervals (99%...
Type 2 inflammation is common in numerous atopic/allergic diseases and can be identified by elevated biomarker levels. Dupilumab, a fully human monoclonal antibody, blocks the shared receptor component for interleukin-4 interleukin-13, key central drivers of type inflammation.
OBJECTIVES: To determine whether inpatient palliative consultation services improve outcomes of care. DESIGN: Retrospective telephone surveys conducted with family members veterans who received or outpatient care from a Department Veterans Affairs (VA) medical facility in the last month life. SETTING: Five VA Medical Centers their affiliated nursing homes and clinics. PARTICIPANTS: had participating One member completed each survey. MEASUREMENTS: The survey assessed nine aspects patient his...
We address the important practical problem of how to select random effects component in a linear mixed model. A hierarchical Bayesian model is used identify any effect with zero variance. The proposed approach reparameterizes so that functions covariance parameters distribution are incorporated as regression coefficients on standard normal latent variables. allow effectively drop out by choosing mixture priors point mass at for variances. Due reparameterization, enjoys conditionally...
Summary Buck Louis GM, Schisterman EF, Sweeney AM, Wilcosky TC, Gore‐Langton RE, Lynch CD, Boyd Barr D, Schrader SM, Kim S, Chen Z, Sundaram R, on behalf of the LIFE Study. Designing prospective cohort studies for assessing reproductive and developmental toxicity during sensitive windows human reproduction development – Paediatric Perinatal Epidemiology 2011; 25: 413–424. The relationship between environment fecundity fertility remains virtually unstudied from a couple‐based perspective in...
Evidence suggesting that persistent environmental pollutants may be reproductive toxicants underscores the need for prospective studies of couples whom exposures are measured.We examined relationship between selected and couple fecundity as measured by time to pregnancy.A cohort 501 who discontinued contraception become pregnant was prospectively followed 12 months trying conceive or until a human chorionic gonadotrophin (hCG) test confirmed pregnancy. Couples completed daily journals on...
Are urinary phthalate concentrations associated with altered semen quality parameters among males recruited from the general population? Urinary levels of metabolites diesters are lower total sperm counts, larger head sizes, and higher percentages morphologically abnormal sperm. High dose experiments in rats implicate phthalates as anti-androgens. Studies involving infertile men seeking care suggest that influence measures raising concern about implications for population. This prospective...
What are the pain characteristics among women, with no prior endometriosis diagnosis, undergoing laparoscopy or laparotomy regardless of clinical indication? Women surgically visualized reported highest chronic/cyclic and significantly greater dyspareunia, dysmenorrhea, dyschezia compared women other gynecologic pathology (including uterine fibroids, pelvic adhesions, benign ovarian cysts, neoplasms congenital Müllerian anomalies) a normal pelvis. Prior research has shown that various...
OBJECTIVE: To investigate whether prepregnancy obesity is associated with adverse pregnancy outcomes among women without chronic disease. METHODS: Singleton deliveries (N=112,309) mothers diseases in the Consortium on Safe Labor, a retrospective U.S. cohort, were analyzed using Poisson regression robust variance estimation. Relative risks and 95% confidence intervals (CIs) estimated perinatal relation to status adjusted for age, race–ethnicity, parity, insurance, smoking alcohol use during...
Management of moderate-to-severe atopic dermatitis (AD) commonly requires long-term treatment. The aim this study was to report the safety and efficacy dupilumab treatment for up 3 years in adults with AD. This ongoing, multicenter, open-label extension (LIBERTY AD OLE; NCT01949311) assessed previously enrolled trials. Patients received 300 mg weekly 148 weeks. primary outcome safety. Of 2677 patients treated, 347 reached week 148. Mean self-reported drug compliance 98.2%. Safety data were...
BackgroundPruritus (itch) is a cardinal symptom in atopic dermatitis (AD).ObjectiveTo evaluate the timing and effect of dupilumab on itch.MethodsAnalysis data from 1505 patients with moderate to severe AD included 4 randomized controlled studies, treated for up 52 weeks. Adults received 300 mg every 2 weeks or placebo monotherapy (SOLO 1: NCT02277743; SOLO 2: NCT02277769), concomitant topical corticosteroids (CHRONOS: NCT02260986); adolescents (≥12 <18 y) were (200 baseline weight <60 kg;...