A5032105584- Dermatology and Skin Diseases
- Urticaria and Related Conditions
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Food Allergy and Anaphylaxis Research
- Contact Dermatitis and Allergies
- Autoimmune Bullous Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- Nail Diseases and Treatments
- Medicine and Dermatology Studies History
- Pain Mechanisms and Treatments
- Stress Responses and Cortisol
- Advancements in Transdermal Drug Delivery
- Adrenal Hormones and Disorders
- Cutaneous lymphoproliferative disorders research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Exercise and Physiological Responses
- Skin Diseases and Diabetes
- Skin and Cellular Biology Research
- Olfactory and Sensory Function Studies
- Dermatological diseases and infestations
- Pharmacological Effects of Natural Compounds
- Genetic and rare skin diseases.
- Dermatologic Treatments and Research
- Hair Growth and Disorders
University of Miami
2016-2025
Pfizer (United States)
2024
American Orchid Society
2023-2024
Creative Commons
2021-2023
University of Miami Hospital
2017-2023
Miami University
2018-2022
Pfizer (United Kingdom)
2021
Eli Lilly (United States)
2021
Novartis (Switzerland)
2021
Regeneron (United States)
2021
Chronic itch is a common and distressing symptom that arises from variety of skin conditions systemic diseases. Despite this, there no clinically based classification pruritic diseases to assist in the diagnosis cost-effective medical care patients with pruritus. The proposed focuses on clinical signs distinguishes between without primary or secondary lesions. Three groups are proposed: pruritus diseased (inflamed) (group I), non-diseased (non-inflamed) II), presenting severe chronic scratch...
Many patients with psoriasis are known to suffer from itch. However, the data available regarding itch and its characteristics in sparse.To examine prevalence of pruritus various related clinical 101 extensive psoriasis.A structured questionnaire was used.Generalized a feature 84% patients. In 77% these it appeared on daily basis. It involved all areas body, had prolonged duration mainly evening at night. The significantly affected quality life. Important factors that were found exacerbate...
Moderate‐to‐severe atopic dermatitis (AD) is a chronic disease characterized by intense, persistent and debilitating itch, resulting in sleep deprivation, signs of anxiety depression, impaired quality life reduced productivity. The Peak Pruritus Numerical Rating Scale (NRS) was developed validated as single‐item, patient‐reported outcome (PRO) itch severity. To describe the content validity psychometric assessment (test–retest reliability, construct validity, known‐groups sensitivity to...
Prurigo nodularis is a chronic pruritic skin disease with multiple nodular lesions. Nemolizumab monoclonal antibody targeting the interleukin-31 receptor, which involved in pathogenesis of prurigo nodularis.
Prurigo nodularis (PN) is a chronic inflammatory skin disease with intensely pruritic nodules. The LIBERTY-PN PRIME and PRIME2 phase 3 trials enrolled adults PN ≥20 nodules severe itch uncontrolled topical therapies. Dupilumab, fully human monoclonal antibody, blocks the shared receptor component for interleukin (IL)-4 IL-13. Patients were randomized 1:1 to 300 mg dupilumab or placebo subcutaneously every 2 weeks 24 weeks. primary endpoint was pruritus improvement, measured by proportion of...
Prurigo nodularis is a chronic, debilitating, and severely pruritic neuroimmunologic skin disease. Nemolizumab, an interleukin-31 receptor alpha antagonist, down-regulates key pathways in the pathogenesis of prurigo nodularis. Download PDF Research Summary. In this phase 3, double-blind, multicenter, randomized trial, we assigned adults with moderate-to-severe to receive initial 60-mg dose nemolizumab followed by subcutaneous injections 30 mg or 60 (depending on baseline weight) every 4...
Chronic pruritus, defined as itch experienced for 6 weeks or longer, affects approximately 22% of people in their lifetime. Approximately 1% physician visits are the chief concern chronic pruritus. pruritus is associated with adverse outcomes, including impaired sleep and reduced quality life.
Objective. The aim of the study was to investigate skin barrier function in neonates different anatomic sites during first 2 days life. Design. population consisted 44 healthy full-term newborn infants. Transepidermal water loss (TEWL), stratum corneum hydration (SCH), and surface pH were measured (forehead, flexor part forearm, upper back, abdomen, inguinal region, palms, soles) 10 hours life 24 later. Measurements recorded with a Tevameter, Corneometer, meter flat glass electrode. Results...
Although pruritus is the predominant and commonest feature of atopic dermatitis, its clinical characteristics have not been explored.To characterize pattern sensory affective dimensions itch experience utilizing a comprehensive questionnaire.A structured questionnaire based on McGill pain was given to 102 Chinese patients with known dermatitis.There were 100 dermatitis who fully filled questionnaire. In 87% appeared daily basis. It had prolonged duration (mean 10.7 7.3 years). involved all...
Journal Article Distinct patterns of brain activity evoked by histamine‐induced itch reveal an association with intensity and disease severity in atopic dermatitis Get access Y. Ishiuji, Ishiuji Department DermatologyDepartment Dermatology, The Jikei University School Medicine, Tokyo, Japan Search for other works this author on: Oxford Academic Google Scholar R.C. Coghill, Coghill Neurobiology & Anatomy Neuroscience Center T.S. Patel, Patel Dermatology Oshiro, Oshiro R.A. Kraft, Kraft...