A5021131852- Dermatology and Skin Diseases
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Urticaria and Related Conditions
- Psoriasis: Treatment and Pathogenesis
- Autoimmune Bullous Skin Diseases
- Food Allergy and Anaphylaxis Research
- Olfactory and Sensory Function Studies
- Stress Responses and Cortisol
- Exercise and Physiological Responses
- Immune Cell Function and Interaction
- Advancements in Transdermal Drug Delivery
- T-cell and B-cell Immunology
- Contact Dermatitis and Allergies
- Skin Diseases and Diabetes
- Pain Mechanisms and Treatments
- Genetic and rare skin diseases.
- Ion Channels and Receptors
- Sport Psychology and Performance
- Abdominal vascular conditions and treatments
- Autoimmune and Inflammatory Disorders
- Hydrogen's biological and therapeutic effects
- Wnt/β-catenin signaling in development and cancer
- Restraint-Related Deaths
- Medical and Biological Sciences
Jikei University School of Medicine
2016-2025
Japanese Urological Association
2024
Yahoo (United Kingdom)
2023
Creative Commons
2023
Wake Forest University
2007-2011
Beiersdorf (Germany)
2009
Journal Article Distinct patterns of brain activity evoked by histamine‐induced itch reveal an association with intensity and disease severity in atopic dermatitis Get access Y. Ishiuji, Ishiuji Department DermatologyDepartment Dermatology, The Jikei University School Medicine, Tokyo, Japan Search for other works this author on: Oxford Academic Google Scholar R.C. Coghill, Coghill Neurobiology & Anatomy Neuroscience Center T.S. Patel, Patel Dermatology Oshiro, Oshiro R.A. Kraft, Kraft...
Abstract Atopic dermatitis ( AD ) is a common inflammatory skin disease that characterized by chronic and persisting pruritic eczematous lesions. There has been no study of work productivity activity in patients relation to severity. The purpose this was examine the impact severity on impairment WPAI adult using J apanese version questionnaire. Data were collected from 112 who visited ikei University Hospital. Outcomes as measured questionnaire included employment status, total TWPI TAI )....
Itching tends to worsen at night in patients with itchy skin diseases, such as atopic dermatitis. Unconscious scratching during sleep can exacerbate symptoms, cause disturbances, or reduce quality of life. Therefore, evaluating nocturnal behaviour is important for better patient care. However, no report exists on the specific detection overnight dermatitis using a non-wearable sensor. A novel algorithm was developed specifically detect sheet-shaped body vibrometer placed under mattress. To...
The relationship between dry skin and uraemic pruritus remains controversial. In addition, there is a lack of published data describing the structure function stratum corneum (SC) in end-stage renal disease (ESRD). purpose present study was to assess barrier patients with ESRD correlate any abnormalities pruritus.Thirty-eight subjects participated study; 20 18 healthy controls. Subjects underwent evaluation SC integrity permeability recovery, surface pH, skin. content glycerol, an important...
Background Repetitive scratching is the most common behavioural response to itch in atopic dermatitis (AD). Patients with chronic often report that very hot showers inhibit itch. We recently reported and noxious heat stimuli histamine‐induced healthy subjects. However, no psychophysical studies have been performed AD assess effects of repetitive pain on Objectives To examine intensity patients using quantitative sensory testing devices. Methods Itch was induced histamine iontophoresis 16...
Lipocalin-2 (LCN2), a protein secreted mainly by activated neutrophils, has been associated with neurodegeneration, obesity, and inflammatory responses. Serum LCN2 concentration reported elevated in patients psoriasis, but lower atopic dermatitis (AD). Spinal astrocyte-derived was found to be involved enhancement of itch mouse model AD. However, the relationship between psoriasis not determined. Objective. This study examined correlation serum levels degrees psoriasis. concentrations were...
Background Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by intermittent itchy rash. Type 2 cytokines such as interleukin (IL)-4, IL-13, and IL-31 are strongly implicated in AD pathogenesis. Stimulation of cognate receptors on C-fiber nerve endings believed to activate neurons the dorsal root ganglion (DRG), causing itch. The receptor heterodimer OSMRβ IL31RA subunits, can also bind oncostatin M (OSM), pro-inflammatory cytokine released monocytes/macrophages,...
Abstract Psoriasis is a chronic inflammatory skin disease mainly mediated by T‐helper cell subset, Th17 cells. Recently, increased levels of total serum immunoglobulin (Ig)E have been reported in subset psoriatic patients. Ustekinumab ( UST ) one the most commonly used biologic agents for treatment moderate to severe plaque psoriasis, and previous report also documented effectiveness patients with high IgE levels. We experienced two levels, whom completely improved psoriasis but...
The aim of this study is to elucidate the relationship between 2 different types severity-indicating parameters (i.e. subjective and objective parametersin patients with atopic dermatitis. disease severity 55 dermatitis was assessed using 7 indicating severity, including visual analogue scale for itch, Patient-Oriented Eczema Measure, 5-D itch scale, Dermatology Life Quality Index, Area Severity body surface area, Investigator Global Assessment, 8 eosinophil relative count,...
BackgroundAtopic dermatitis (AD) is a common chronic eczematous skin disease with severe pruritus. Several new therapeutic agents for AD such as dupilumab, an anti–IL-4Rα antibody, have been developed in recent years. We need to predict which agent the best choice each patient, but this remains difficult.ObjectiveOur aim was examine clinical background factors and baseline biomarkers that could achievement of improved outcomes patients treated dupilumab.MethodsA multicenter, prospective...
Abstract The T‐cell immunoglobulin and immunoreceptor tyrosine‐based inhibitory motif domain (TIGIT) is a co‐inhibitory receptor mainly expressed on T cells. Although TIGIT plays an important role in various autoimmune diseases, its atopic dermatitis (AD) remains unclear. In this study, we examined the expression levels of their association with clinical features patients AD. CD4 + cells, central memory effector cells regulatory was determined by flow cytometry. exhibited enhanced AD...
Background: Atopic dermatitis (AD) is a common eczematous skin disorder that profoundly reduces the quality of life due to intractable pruritus. Excellent therapeutic success anti-interleukin 4 receptor-α antibody dupilumab in clinical trials and real-world context indicates crucial roles interleukin (IL)-4 IL-13 pathogenesis AD. Along with improvement scores pruritus, significantly progressively normalizes upregulated expression T helper type 2 signatures such as Chemokine (C-C motif)...
To develop precision medicine for atopic dermatitis (AD), it is critical to establish relevant biomarkers. However, the characteristics of various biomarkers have not been fully understood. We previously carried out Biomarkers Predict Clinical Improvement AD in Patients Treated with Dupilumab (B-PAD) study, a comprehensive nationwide study Japan, explore AD.The aim this find associated objective and subjective clinical findings patients moderate-to-severe based on B-PAD identify sensitive...
As yet no transdermal topical formulations have been developed for the treatment of chronic itch. We a formulation containing 2 mg butorphanol tartrate in 100 microl purified water encapsulated into multilamellar phospholipid vesicles. Drug permeation experiments were studied with Franz diffusion chambers using human skin vitro and on rat vivo. Histological analysis skins was performed to evaluate irritation Physical properties showed stable desirable viscosity. In dermal penetration rate...