A5031575826- Dermatology and Skin Diseases
- Allergic Rhinitis and Sensitization
- Psoriasis: Treatment and Pathogenesis
- Asthma and respiratory diseases
- Receptor Mechanisms and Signaling
- Microbial bioremediation and biosurfactants
- Urticaria and Related Conditions
- Enzyme Structure and Function
- bioluminescence and chemiluminescence research
- Photoreceptor and optogenetics research
- Mast cells and histamine
- Autoimmune Bullous Skin Diseases
- Biochemical and Molecular Research
- Contact Dermatitis and Allergies
- Nosocomial Infections in ICU
- Microbial metabolism and enzyme function
- Biochemical Acid Research Studies
- Skin Diseases and Diabetes
- Vasculitis and related conditions
- Ion channel regulation and function
- Cancer and Skin Lesions
- Chemical Reactions and Isotopes
- Liver Diseases and Immunity
- Neuropeptides and Animal Physiology
- Nonmelanoma Skin Cancer Studies
Nippon Medical School
2016-2025
Nippon Medical School Hospital
2016-2024
Gakushuin University
2005-2014
Nagoya University Hospital
1995-2011
RIKEN Center for Brain Science
2009
Kyoto University
1998-2007
Kyoto University Institute for Chemical Research
1998-2007
Kyoto Bunkyo University
2007
SPring-8
2006
RIKEN
2006
Abstract This is the English version of Clinical Practice Guidelines for Management Atopic Dermatitis 2021. dermatitis (AD) a disease characterized by relapsing eczema with pruritus as primary lesion. In Japan, from perspective evidence‐based medicine, current strategies treatment AD consist three measures: (i) use topical corticosteroids, tacrolimus ointment, and delgocitinib ointment main inflammation; (ii) application emollients to treat cutaneous barrier dysfunction; (iii) avoidance...
Psoriasis is accompanied by systemic inflammation that includes the liver. The fibrosis-4 (FIB-4) index was developed to predict significant liver fibrosis. present study evaluated effects of biologics, including TNF inhibitors, on FIB-4 in psoriasis patients. All adult patients with who were prescribed biologics (TNF IL-17 or IL-23 inhibitors) at Nippon Medical School from June 2014 January 2024 for first time (biologic-naïve patients) included this study. calculated before and after 6...
Fluoroacetate dehalogenase (EC 3.8.1.3) catalyzes the dehalogenation of fluoroacetate and other haloacetates. The amino acid sequence from <i>Moraxella</i>sp. B is similar to that haloalkane 3.8.1.5) from<i>Xanthobacter autotrophicus</i> GJ10 in regions around Asp-105 His-272, which correspond active site nucleophile Asp-124 base catalyst His-289 dehalogenase, respectively (Krooshof, G. H., Kwant, E. M., Damborský, J., Koča, Janssen, D. B. (1997)<i>Biochemistry</i> 36, 9571–9580). After...
BackgroundAtopic dermatitis (AD) is a common chronic eczematous skin disease with severe pruritus. Several new therapeutic agents for AD such as dupilumab, an anti–IL-4Rα antibody, have been developed in recent years. We need to predict which agent the best choice each patient, but this remains difficult.ObjectiveOur aim was examine clinical background factors and baseline biomarkers that could achievement of improved outcomes patients treated dupilumab.MethodsA multicenter, prospective...
Abstract Psoriasis is a chronic, relapsing, inflammatory keratotic skin disease. To elucidate the medication adherence and treatment satisfaction, we performed questionnaire survey using eight‐item Morisky Medication Adherence Scale ( MMAS ‐8) nine‐item Treatment Satisfaction Questionnaire for TSQM ‐9) of 163 psoriatic patients who regularly visited hospitals or clinics. assess relationship between ‐8/ ‐9 outcomes severity psoriasis, two different clinical indices were used: Area Severity...
Abstract Background Acanthosis nigricans ( AN ) can occur as a cutaneous manifestation of genetic diseases, one which is associated with activating mutations the fibroblast growth factor receptor 3 gene FGFR ). Objective We explored familial patients and examined effectiveness glycolic acid GA peeling in improving their skin manifestations. Methods Sanger sequencing was performed for genomic DNA extracted from leucocytes family members involving . carried out two once every 2 weeks. Results...
Background: Atopic dermatitis (AD) is a common eczematous skin disorder that profoundly reduces the quality of life due to intractable pruritus. Excellent therapeutic success anti-interleukin 4 receptor-α antibody dupilumab in clinical trials and real-world context indicates crucial roles interleukin (IL)-4 IL-13 pathogenesis AD. Along with improvement scores pruritus, significantly progressively normalizes upregulated expression T helper type 2 signatures such as Chemokine (C-C motif)...
To develop precision medicine for atopic dermatitis (AD), it is critical to establish relevant biomarkers. However, the characteristics of various biomarkers have not been fully understood. We previously carried out Biomarkers Predict Clinical Improvement AD in Patients Treated with Dupilumab (B-PAD) study, a comprehensive nationwide study Japan, explore AD.The aim this find associated objective and subjective clinical findings patients moderate-to-severe based on B-PAD identify sensitive...
We have examined whether the long third intracellular loop (i3) of muscarinic acetylcholine receptor M 2 subtype has a rigid structure. Circular dichroism (CD) and nuclear magnetic resonance spectra i3 expressed in purified from Escherichia coli indicated that consists mostly random coil. In addition, differential CD spectrum between Δi3 receptors, latter which lacks most except N‐ C‐terminal ends, gave no indication secondary These results suggest central part flexible
Abstract This is the English version of 2024 clinical practice guidelines for management atopic dermatitis (AD). AD a disease characterized by relapsing eczema with pruritus as primary lesion. A crucial aspect treatment prompt induction remission via suppression existing skin inflammation and pruritus. To achieve this, topical anti‐inflammatory drugs, such corticosteroids, tacrolimus ointment, delgocitinib difamilast have been used. However, following treatments should be considered in...
Metabolic dysfunction-associated steatotic liver disease (MASLD) is positively associated with the prevalence and severity of psoriasis. The fibrosis-4 (FIB-4) index was developed to predict significant fibrosis. Using FIB-4 index, present study evaluated screening data for fibrosis, including MASLD, in patients refractory psoriasis treated biologics.
dl-2-Haloacid dehalogenase from Methylobacterium sp. CPA1 (dl-DEX Mb) is a unique enzyme that catalyzes the dehalogenation reaction without formation of an ester intermediate. A recombinant form dl-DEX Mb has been expressed in Escherichia coli, purified and crystallized using hanging-drop vapour-diffusion method. The crystal belongs to hexagonal space group P63, with unit-cell parameters = b 186.2, c 114.4 Å. crystals are likely contain between four eight monomers asymmetric unit, VM value...
Abstract Background Dupilumab, a fully human monoclonal antibody that blocks signalling pathways of interleukin (IL)‐4 and IL‐13, is effective in treating patients with atopic dermatitis (AD). We previously showed transitions serum thymus activation‐regulated chemokine (TARC) levels eosinophil numbers were strongly associated AD activity the lactate dehydrogenase (LDH) immunoglobulin E (IgE) weakly not activity, respectively, treated without dupilumab. Objectives The purpose this study was...
Psoriasis is a chronic immune-mediated inflammatory skin disease characterized by hyperproliferation of epidermal keratinocytes. Biologics have been available for the treatment patients with refractory psoriasis since 2010 in Japan, and as December 2021, 10 biologics were available. The Review Committee Japanese Dermatological Association recommends blood examination tests antinuclear antibodies (ANA), Krebs von den Lugen (KL)-6, hepatitis B surface antigen (HBsAg), (HBsAb), core (HBcAb), C...
Three categories of biologics-tumor necrosis factor (TNF) inhibitors, interleukin (IL) -17 and IL-23 inhibitors-are available for treatment refractory psoriasis. Recent studies have shown that laboratory biomarkers such as peripheral blood neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte (PLR), monocyte-lymphocyte (MLR), serum C-reactive protein (CRP) levels are associated with psoriasis or its severity. This study evaluated associations transition NLR, PLR, MLR, CRP disease activity...