A5038334551- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Dermatology and Skin Diseases
- Eosinophilic Esophagitis
- Contact Dermatitis and Allergies
- Child Nutrition and Feeding Issues
- Urticaria and Related Conditions
- Neonatal Respiratory Health Research
- Pregnancy and Medication Impact
- Effects and risks of endocrine disrupting chemicals
- Maternal Mental Health During Pregnancy and Postpartum
- Pediatric health and respiratory diseases
- Breastfeeding Practices and Influences
- Respiratory viral infections research
- Immunodeficiency and Autoimmune Disorders
- Birth, Development, and Health
- Pharmaceutical studies and practices
- Neonatal skin health care
- Respiratory and Cough-Related Research
- Obesity, Physical Activity, Diet
- Mobile Health and mHealth Applications
- Drug-Induced Adverse Reactions
- Health Literacy and Information Accessibility
- Digital Mental Health Interventions
National Center For Child Health and Development
2016-2025
National University Health System
2024
Oxfam
2023
Liechtenstein Institute
2023
John Wiley & Sons (United States)
2023
John Wiley & Sons (United Kingdom)
2023
Hudson Institute
2023
Aichi Medical University
2015-2019
Yamamoto Hospital
2015
Yamaguchi University
2009
Abstract Atopic dermatitis ( AD ) is a disease characterized by relapsing eczema with pruritus as primary lesion. The current strategies to treat in Japan from the perspective of evidence‐based medicine consist three measures: (i) use topical corticosteroids and tacrolimus ointment main treatment for inflammation; (ii) application emollients cutaneous barrier dysfunction; (iii) avoidance apparent exacerbating factors, psychological counseling advice about daily life. guidelines present...
BackgroundIn the past few decades, prevalence of allergic diseases has increased rapidly worldwide. At same time, overuse antibiotics been observed, especially in Japan.ObjectiveTo elucidate association early childhood antibiotic use with later at 5 years age.MethodsRelevant data were extracted from hospital-based birth cohort study, Tokyo Children's Health, Illness and Development Study. To identify signs asthma children, International Study Asthma Allergies Childhood questionnaire was...
The aims of the present report were to estimate prevalence congenital anomalies (CAs) among infants in Japan using data from Environment and Children's Study (JECS) evaluate validity CA classification within JECS.
Capturing epidemiological signatures is essential to document burdens of disease and design health care services, including prevention measures, clinical interventions, policies. There are large geographical ethnic variations in the epidemiology allergic immunological diseases. Various data available from North America Europe, but diseases Asia not well documented.
Abstract This is the English version of Clinical Practice Guidelines for Management Atopic Dermatitis 2021. dermatitis (AD) a disease characterized by relapsing eczema with pruritus as primary lesion. In Japan, from perspective evidence‐based medicine, current strategies treatment AD consist three measures: (i) use topical corticosteroids, tacrolimus ointment, and delgocitinib ointment main inflammation; (ii) application emollients to treat cutaneous barrier dysfunction; (iii) avoidance...
Importance Atopic dermatitis onset usually occurs in childhood. Persistence of disease into adolescence and adulthood is common. It important to evaluate new treatment options adolescents because the high unmet need this population. Objective To assess efficacy safety upadacitinib treat moderate-to-severe atopic adolescents. Design, Setting, Participants Prespecified analysis enrolled 3 randomized, double-blind, placebo-controlled phase clinical trials more than 20 countries across Europe,...
Although pregnancies conceived by assisted reproductive technology (ART) have a higher risk of maternal/perinatal complications, the overall adverse outcomes necessitating advanced obstetric care has not been closely examined. The present study aimed to assess and compare complications in pregnancy childbirth ART with those naturally.This was conducted as part Japan environment children's (JECS), an ongoing nationwide birth cohort Japan. assessed mode conception (natural conception,...
The molecular pathogenesis of atopic dermatitis (AD), presenting skin barrier dysfunction and abnormal inflammations around 1-2 months, is unreported.We aimed to examine the very early-onset AD by surface lipid-RNA (SSL-RNA) using a non-invasive technology in infants aged 1 2 months from prospective cohort.We collected sebum oil-blotting film analysed RNAs their sebum. We diagnosed according United Kingdom Working Party's criteria.Infants with month showed lower expression genes related...
Abstract Food allergy is postulated to originate from cutaneous sensitization through a disrupted skin barrier, particularly in atopic dermatitis (AD). Strategies for food prevention currently centre around early allergic introduction, but there now increasing evidence the role of barrier restoration form prophylactic emollient therapy and aggressive, proactive treatment established AD prevention. Research gaps that remain be addressed include type or anti‐inflammatory medication, which...
The Japanese Guideline for Childhood Asthma (JGCA) 2020 is a translation of the Pediatric Treatment and Management (JPGL) 2017 into English, which was published by Society Allergy Clinical Immunology. It makes recommendations best practices in management childhood asthma, including acute exacerbations non-pharmacological pharmacological management. These guidelines will be interest to non-specialist physicians involved care children with asthma. In JPGL, JPGL2017 first evidence-based updated...
Skin inflammation leads to altered cytokine/chemokine production and causes systemic inflammation. The mechanism of atopic dermatitis (AD) is recognized affect metabolism. This study aimed examine the relationship between early-onset persistent eczema body weight, height, mass index (BMI), in addition food allergy a birth cohort among infants. design was nationwide, multicenter, prospective study—the Japan Environment Children’s Study (JECS). Generalized linear models were fitted for z...
Safer and more effective cow milk (CM)-oral immunotherapy that does not induce allergic reactions has yet been standardised. We sought to explore the efficacy feasibility of a combination heat-killed Lactiplantibacillus plantarum YIT 0132 (LP0132) oral for treating IgE-mediated allergy (CMA). conducted 24-week, double-blind, randomised (1:1), two-arm, parallel-group, placebo-controlled, phase 2 trial LP0132 intervention CMA in children aged 1-18 years (n=60) from January 29, 2018 July 12,...
Severe asthma attacks can be life-threatening and contribute to a high global mortality rate. Traditionally, severe in children are influenced by poor access care, suboptimal drug regimens, comorbid allergic diseases, environmental exposures (such as tobacco smoke, pollutants, allergens fungi), obesity, genetic factors socio-economic conditions [1-3]. The past review addressed that with were likelier have non-allergic chronic diseases comorbidities [4]. We speculated the contributing...
Down syndrome (DS) is a risk factor for severe food protein-induced enterocolitis (FPIES), with DS patients tending to have multiple-food FPIES. This the first case where infant history of chronic FPIES milk and soy could effectively be introduced some untested high-risk foods through hospital-based oral challenges (OFCs). The 20-month-old girl DS, who was diagnosed milk- soy-induced Considering her intensive care unit reactions, we considered that introducing other foods, such as wheat...