A5084094196- Birth, Development, and Health
- Renal Diseases and Glomerulopathies
- Maternal Mental Health During Pregnancy and Postpartum
- Gestational Diabetes Research and Management
- Pregnancy and preeclampsia studies
- Pregnancy and Medication Impact
- Breastfeeding Practices and Influences
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Neurogenetic and Muscular Disorders Research
- Systemic Lupus Erythematosus Research
- Fetal and Pediatric Neurological Disorders
- Neonatal Respiratory Health Research
- Neurological Complications and Syndromes
- Pharmacological Effects and Toxicity Studies
- Respiratory viral infections research
- RNA modifications and cancer
- Kawasaki Disease and Coronary Complications
- Immunodeficiency and Autoimmune Disorders
- Ectopic Pregnancy Diagnosis and Management
- Teratomas and Epidermoid Cysts
- Coronary Artery Anomalies
- Neurosurgical Procedures and Complications
- Congenital Diaphragmatic Hernia Studies
Yokohama City University
2010-2025
Hyogo University
2024
Kyoto University
2023
National Center For Child Health and Development
2010-2022
Hyogo Prefectural Amagasaki General Medical Center
2021-2022
Nagoya City University
2021
Fukushima Prefectural Culture Center
2020
Kanagawa Children's Medical Center
1996
Capturing epidemiological signatures is essential to document burdens of disease and design health care services, including prevention measures, clinical interventions, policies. There are large geographical ethnic variations in the epidemiology allergic immunological diseases. Various data available from North America Europe, but diseases Asia not well documented.
Background. Childhood-onset systemic lupus erythematosus (SLE) is frequently complicated with nephritis (LN), which characterized by the deposition of DNA-containing immune complex to glomerulus. Toll-like receptor 9 (TLR9), capable recognizing microbially derived CpG oligonucleotide, plays a crucial role in innate immunity. TLR9 also assumed be related aetiology SLE recognition anti-DNA antibody-containing complex, but this remains controversial. We conducted study elucidate association...
Abstract Purpose The effects of general anesthesia on neurodevelopment in children remain controversial. We explored the relationship between and participating Japan Environment Children’s Study (JECS). Methods This study enrolled born 37 41 weeks pregnancy via single-vaginal delivery to pregnant women registered JECS January 2011 March 2014. Data were collected from mother-completed questionnaires medical transcripts. Neurodevelopment five domains was assessed every 6 months 12 48 age,...
Abstract Background Atopic dermatitis (AD) is reported to be more prevalent in children who were born autumn than spring. Here, we investigated how early the association between season of birth and eczema or AD can observed postnatal period. We also examined whether specific prevalence outcomes for infant differed according sex maternal history allergic disease a large Japanese cohort. Methods Using data 81,615 infants from Japan Environment Children’s Study, associations month with four...
Abstract Background Determining the appropriate preconception care to reduce occurrence of hypertensive disorder pregnancy (HDP) remains a challenge in modern obstetrics. This study aimed examine association between pre-pregnancy calcium (Ca) intake and HDP normotensive primiparas. Methods We used data from Japan Environment Children’s (JECS), which is largest birth cohort study. A total 33,894 Japanese primiparas were recruited for JECS January 2011 March 2014. Participants categorized into...
Abstract Background The deletion region of 22q11.2 syndrome (22q11.2DS) contains a gene encoding glycoprotein Ibβ (GPIbβ), which is required to express the GPIb/IX/V complex on platelet surface. Therefore, patients with 22q11.2DS may have congenital disorders. However, information limited platelets and bleeding symptoms. In this study, we investigated clinical information, including symptoms, counts, GPIb expression levels in children adolescents/adults 22q11.2DS. Procedure Thirty‐two were...
Abstract Background Previous studies revealed positive, negative, and no influence of social capital on the health outcomes pregnant women. It was considered that such differences were caused by disparities outcome measures sample sizes between studies. Our chief aim to verify positive condition women using established large-scale nationwide survey data. Methods We employed questionnaire data from 79,210 respondents Japan Environment Children’s Study, physical mental component summary scores...
Abnormal maternal gestational weight gain (GWG) increases the risk of obstetric-related complications. This investigation examined impact GWG on infant neurodevelopmental abnormalities at 12 months age using data a nationwide Japanese cohort study. Questionnaire were obtained from ongoing Japan Environment and Children's Study Maternal was subdivided as below, within, or above reference values Institution Medicine pregnancy guidelines. The Ages Stages Questionnaire, third edition (ASQ-3) is...
Abstract Background Postpartum depression is one of the most commonly experienced psychological disorders for women after childbirth, usually occurring within year. This study aimed to clarify whether with delivery anesthesia, including epidural analgesia, spinal-epidural and paracervical block, had a decreased risk postpartum giving birth in Japan. Methods The Japan Environment Children’s Study (JECS) was prospective cohort that enrolled registered fetal records (n = 104,065) 15 regions...
Abstract Maternal tobacco smoke exposure during pregnancy impairs fetal body size, including head circumference (HC) at birth; however, the mechanism still remains unclear. This analysis using a large prospective cohort study evaluated impact of maternal on their offspring’s HC and relationship with placental weight ratio (PWR) abnormalities. Parents-children pairs (n = 84,856) were included from 104,065 records Japan Environmental Children’s Study. perinatal clinical social information by...
In reproductive medicine, vitamin D (VitD) is of particular interest because its deficiency has been linked to various infertility issues. Thus, preconception care, including appropriate VitD supplementation, essential, especially in women using assisted technology (ART). Despite the therapeutic benefits VitD, adverse events due a high daily intake may influence obstetric outcomes. However, effects either low or on outcomes, outcomes who used ART, remain unclear. Therefore, aim this study...
Women with nausea and vomiting of pregnancy (NVP) have higher birth weight infants, while those hyperemesis gravidarum, a severe manifestation NVP, lower infants. We aimed to investigate the associations between maternal loss (a consequence gravidarum), infant weight.This study was secondary analysis nationwide cohort in Japan. Singleton pregnancies delivered at 28-41 weeks gestation were included analysis. categorized based on their change 1st trimester (as proportion pre-pregnancy weight:...
N-3 polyunsaturated fatty acids (n-3 PUFAs), which are an important nutrient for humans, particularly essential to the growth and development of central nervous system (CNS) in fetuses infants. Consequently, sufficient n-3 PUFA intake by mothers during pregnancy is considered contribute CNS their known be associated with sleep, but no large epidemiological studies have yet confirmed that infants' sleep.After exclusion multiple imputation from a dataset comprising 104 065 records Japan...
The association of maternal preconception dysmenorrhea, especially primary with obstetric complications has not been clearly described. Therefore, we evaluated the dysmenorrhea while accounting for presence pelvic pathologies.We analyzed data women singleton live births at and after 22 weeks gestation enrolled in Japan Environment Children's Study, a nationwide birth cohort study, between 2011 2014. Participants psychological disorders were excluded. Preconception identified medical record...
Abstract Background Healthcare workers are often exposed to hazardous agents and at risk for adverse health consequences that affect not only themselves but also their infants. This study aimed examine whether such occupational exposure increased the of childhood cancer in offspring. Methods We used dataset Japan Environment Children’s Study, a nationwide birth cohort involving over 100,000 mother–child pairs. Information was obtained via successive questionnaires were completed until child...