A5101610828- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Urban and spatial planning
- Biochemical Analysis and Sensing Techniques
- Nutritional Studies and Diet
- Phytoestrogen effects and research
- Cancer Risks and Factors
- Metabolism, Diabetes, and Cancer
- Diet and metabolism studies
- Glioma Diagnosis and Treatment
- Viral gastroenteritis research and epidemiology
- Virus-based gene therapy research
- Pancreatic function and diabetes
- GABA and Rice Research
- Global Cancer Incidence and Screening
- Rice Cultivation and Yield Improvement
- Respiratory viral infections research
- Land Use and Ecosystem Services
- Meningioma and schwannoma management
- Colorectal Cancer Screening and Detection
- Diabetes Treatment and Management
- Fatty Acid Research and Health
- Genetic Mapping and Diversity in Plants and Animals
- Glaucoma and retinal disorders
Fujisawa City Hospital
2015-2025
Japan Pediatric Society
2024
Tokyo Medical University
2019-2024
Kanagawa Children's Medical Center
2019-2023
Nagoya University
2012-2023
Clinical Trial Investigators
2022
Hokkaido Agricultural Research Center
2002-2022
National Agriculture and Food Research Organization
2007-2022
National Agricultural Research Organisation
2022
Kiryu University
2010-2021
The decrease in estrogen menopausal women increases body fat. present studies were undertaken to investigate the involvement of leptin production vivo. In first study, expression ob gene mRNA white adipose tissue was measured at 2 and 8 weeks after ovariectomy rats. second, serum concentration total fat 87 weight-matched human subjects (29 men, 29 premenopausal postmenopausal women). third, changes with menstrual cycle determined. decreased subcutaneous retroperitoneal ovariectomized rats...
Nesfatin-1 is a novel satiety molecule in the hypothalamus and also present peripheral tissues. Here we sought to identify active segment of nesfatin-1 determine mechanisms its action after administration mice. Intraperitoneal injection suppressed food intake dose-dependent manner. has three distinct segments; tested effect each on intake. Injection midsegment decreased under leptin-resistant conditions such as db/db mice fed high-fat diet. After midsegment, expression c-Fos was...
Background and Purpose— Despite the evidence for a positive association of dietary salt blood pressure, few prospective studies that have assessed between stroke reported inconsistent results. The purpose this study was to examine relation sodium intake death from in population-based cohort Japanese men women. Methods— In 1992, usual diet including determined 13 355 15 724 women Takayama City, Gifu, with use validated food frequency questionnaire. Results— There were 269 deaths (137 132...
Corticotropin-releasing factor (CRF) has been administered into the third ventricle of rats in acute and chronic experiments. Following a single 5-micrograms injection CRF, there was an reduction food intake at 30 60 min that no longer significant 3 h. Guanosine 5'-diphosphate (GDP) binding to mitochondria from interscapular brown adipose tissue (IBAT) 21-h deprived significantly increased after infusion 5 micrograms CRF. Serum corticosterone elevated both groups but higher group treated...
OBJECTIVE: To examine the relationship between depressive symptoms and incidence of type 2 diabetes. RESEARCH DESIGN AND METHODS: In 1984, 2,764 male employees an electrical company in Japan completed a self-administered questionnaire including Zung Self-Rating Depression Scale (SDS). They were followed for next 8 years, 2,380 (86%) responded to follow-up survey 1992. During survey, occurrence diabetes was diagnosed according World Health Organization criteria. RESULTS: A total 41 cases...
Nesfatin-1, a newly discovered satiety molecule, is located in the hypothalamic nuclei, including paraventricular nucleus (PVN) and supraoptic (SON). In this study, fine localization regulation of nesfatin-1 neurons PVN SON were investigated by immunohistochemistry neuropeptides c-Fos. PVN, 24% overlapped with oxytocin, 18% vasopressin, 13% CRH, 12% TRH neurons. SON, 35% oxytocin 28% vasopressin. After 48-h fast, refeeding for 2 h dramatically increased number expressing c-Fos...
Bullous pemphigoid (BP) is a blistering skin disease in which autoantibodies develop to hemidesmosomal components of the epidermal basement membrane zone, including two major antigenic proteins 230-kD antigen (BPAG1) and 180-kD (BPAG2). The present study demonstrated precise ultrastructural localization epitopes for against BPAG1 BPAG2 normal skin. Autoantibodies either or were affinity-purified using nitrocellulose membrane, was blotted with SDS-PAGE-fractionated antigens from human extract...
Summary Background We recently identified a novel anorexigenic protein, nesfatin‐1, which is processed from nesfatin/nucleobindin‐2 (NUCB2). However, the clinical importance of this protein has not been determined. Objective To investigate its significance in humans, we have established new specific enzyme‐linked immunosorbent assay (ELISA) for human nesfatin‐1 peripheral blood and measured circulating concentration healthy subjects. Design The sandwich‐type ELISA method was validated then...
Although the inverse association between coffee consumption and risk of diabetes has been reported numerous times, role caffeine intake in this remained unclear. We evaluated other beverages food containing relation to incidence diabetes. The study participants were 5897 men 7643 women a community-based cohort Takayama, Japan. Consumption coffee, green tea, oolong black tea chocolate snacks measured with semi-quantitative FFQ 1992. At follow-up survey 2002, development time diagnosis...
Leptin, ob gene product, inhibits feeding behavior and stimulates energy expenditure in rodents. Corticotropin-releasing hormone (CRH) neuropeptide Y (NPY), which act the hypothalamus to influence homeostasis, may mediate anorexic effect of leptin. The present studies were undertaken examine possible involvement hypothalamic CRH anorexigenic action leptin male Wistar rats. Recombinant (2 microg/rat), microinjected into third ventricle, inhibited food intake at 2 h by 33.3% (P < 0.01) rats...