A5023093481- IgG4-Related and Inflammatory Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neuroendocrine Tumor Research Advances
- Gastrointestinal disorders and treatments
- Colorectal Cancer Surgical Treatments
- Neonatal Respiratory Health Research
- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Medical Imaging and Pathology Studies
- Sarcoidosis and Beryllium Toxicity Research
- Liver Disease Diagnosis and Treatment
- Systemic Lupus Erythematosus Research
- Tracheal and airway disorders
- Colorectal Cancer Treatments and Studies
- Immune Cell Function and Interaction
- Inhalation and Respiratory Drug Delivery
- Immunotherapy and Immune Responses
- Lung Cancer Treatments and Mutations
- Salivary Gland Tumors Diagnosis and Treatment
- Systemic Sclerosis and Related Diseases
- Vascular Malformations and Hemangiomas
- Inflammatory Bowel Disease
- Peripheral Artery Disease Management
- Cytokine Signaling Pathways and Interactions
Nagoya City University
2016-2025
Sapporo Medical University
2015-2024
Mizuho (Japan)
2007-2024
University of Electro-Communications
2022-2024
Yamagata University
2013-2024
Kameda Medical Center
2024
Liechtenstein Institute
2023
Tokushima University
2023
University of Tsukuba
2023
Saiseikai Ibaraki Hospital
2023
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease without proven effective therapy. A multicentre, double-blind, placebo-controlled, randomised phase III clinical trial was conducted in Japanese patients with well-defined IPF to determine the efficacy and safety of pirfenidone, novel antifibrotic oral agent, over 52 weeks. Of 275 (high-dose, 1,800 mg·day −1 ; low-dose, 1,200 or placebo groups ratio 2:1:2), 267 were evaluated for pirfenidone. Prior unblinding, primary...
Idiopathic pulmonary fibrosis (IPF) has an unknown etiology and poor prognosis. Several large-scale epidemiologic studies have been conducted predominantly in Western countries. There are few reported from Asian It remains unclear whether ethnic difference exists IPF. is important to determine the current IPF status populations compare it with that of populations.To provide Japan investigate differences.We selected Hokkaido prefecture (population, 5.6 million) as cohort among Japanese. On...
IgG4-related disease (IgG4-RD) is a fascinating clinical entity first reported in this century Japan, and includes wide variety of diseases, such as formerly named Mikulicz's (MD), autoimmune pancreatitis (AIP), interstitial nephritis, prostatitis retroperitoneal fibrosis. The Japanese IgG4 team organized by the Ministry Health, Labor Welfare (MHLW) Japan has published criteria, comprehensive diagnostic (CD) criteria for IgG-RD 2011. Thereafter, IgG4-RD been accepted widely many cases have...
P001 - Sepsis impairs the capillary response within hypoxic capillaries and decreases erythrocyte oxygen-dependent ATP efflux R. M. Bateman, D. Sharpe, J. E. Jagger, C. G. Ellis P002 Lower serum immunoglobulin G2 level does not predispose to severe flu. Solé-Violán, López-Rodríguez, Herrera-Ramos, Ruíz-Hernández, L. Borderías, Horcajada, N. González-Quevedo, O. Rajas, Briones, F. Rodríguez de Castro, Gallego P003 Brain protective effects of intravenous through inhibition complement...
Interleukin-6 (IL-6) has an important role in cancer progression, and high levels of plasma IL-6 are correlated with a poor prognosis variety cancers. It also been reported that tumour stromal fibroblasts necessary for steps such as angiogenesis. There have few reports correlation between fibroblast actions levels. In this study, we examined the utility therapeutic target human colon cancer. The expression VEGF cell lines were evaluated using real-time PCR ELISA. anti-angiogenic effect...
Journal Article Risk of malignancies in IgG4-related disease Get access Motohisa Yamamoto, Yamamoto First Department Internal Medicine, Sapporo Medical University School South 1-West 16, Chuo-ku, Sapporo, Hokkaido 0608543, Japan Correspondence to: e-mail: mocha@cocoa.plala.or.jp Search for other works by this author on: Oxford Academic Google Scholar Hiroki Takahashi, Takahashi Tetsuya Tabeya, Tabeya Chisako Suzuki, Suzuki Yasuyoshi Naishiro, Naishiro Keisuke Ishigami, Ishigami Hidetaka...
IgG4-related disease (IgG4-RD) is considered a systemic, chronic, and inflammatory disorder that characterized by the enlargement of involved organs, elevated levels IgG4, abundant infiltration plasmacytes with IgG4 fibrosis in organs. It necessary to differentiate IgG4-RD from malignant tumors. Recently we have looked at case reports malignancy was discovered systemic screening. In this study, analyzed relationship between malignancies. The study subjects were 106 patients who had been...
Summary Background Although thiopurines have a proven role in maintenance therapy for Crohn's disease, an alternative is needed patients intolerant or resistant to thiopurines. Aim To evaluate the effectiveness of home enteral nutrition as regimen which half daily calorie requirement provided by elemental diet and remaining free diet. We refer this ‘half diet’. Methods Between 2002 2005, 51 remission from two hospitals were randomly assigned group ( n = 26) 25). The primary outcome measure...
Objective. Mikulicz's disease (MD) has been included within the diagnosis of primary Sjögren's syndrome (SS), but represents a unique condition involving enlargement lachrymal and salivary glands characterized by few autoimmune reactions good responsiveness to glucocorticoids. We have previously described elevated immunoglobulin (Ig) G4 in serum four patients with MD. In this paper, we accumulated more MD cases undertook clinical histopathological analysis these clarify differences between SS.
Abstract CXC‐chemokines are involved in the chemotaxis of neutrophils, lymphocytes and monocytes. However, role these chemokines tumorigenesis, especially with regard to interaction between tumor its microenvironment, has not been clearly elucidated. The purpose this study was analyze co‐operative CXCL8 CXCL12 tumor‐stromal pancreatic cancer (PaCa). Using enzyme‐linked immunosorbent assay (ELISA) reverse transcription polymerase chain reaction (RT‐PCR), we initially confirmed expression...
Gastro-esophageal reflux and related pulmonary bile acid aspiration were prospectively investigated as possible contributors to postlung transplant bronchiolitis obliterans syndrome (BOS). We also studied the impact of on surfactant collectin proteins SP-A SP-D phospholipids--all important components innate immunity in lung. Proximal distal esophageal 24-h pH testing broncho-alveolar lavage fluid (BALF) assays performed at 3-month posttransplant 50 patients. BALF was assayed for SP-A,...
Pulmonary alveolar microlithiasis is an autosomal recessive disorder in which microliths are formed the space.To identify responsible gene that causes pulmonary microlithiasis.By means of a genomewide single-nucleotide polymorphism analysis using DNA from three patients, we have narrowed region candidate located. From this region, identified has mutations all patients with microlithiasis.We gene, SLC34A2, encodes type IIb sodium phosphate cotransporter and mutated six investigated. SLC34A2...
An enzyme-linked immunosorbent assay using monoclonal antibodies to human lung surfactant protein A (SP-A) was applied sera from patients with diseases. We examined whether SP-A appears in the of diseases that are known cause alterations composition bronchoalveolar lavage fluids, and we characterized found. The level 57 healthy volunteers 45 ± 3 ng/ml (mean SEM). levels idiopathic pulmonary fibrosis (IPF) (205 23 ng/ml, n = 32) alveolar proteinosis (PAP) (285 6) were significantly higher...
Summary Background We recently identified a novel anorexigenic protein, nesfatin‐1, which is processed from nesfatin/nucleobindin‐2 (NUCB2). However, the clinical importance of this protein has not been determined. Objective To investigate its significance in humans, we have established new specific enzyme‐linked immunosorbent assay (ELISA) for human nesfatin‐1 peripheral blood and measured circulating concentration healthy subjects. Design The sandwich‐type ELISA method was validated then...
The forkhead box protein 3 (FOXP3) transcription factor is highly expressed in tumor cells as well regulatory T (Tregs). It plays a tumor-enhancing role Tregs and suppresses carcinogenesis potent repressor of several oncogenes. clinical prognostic value FOXP3 expression has not yet been elucidated. In this study, immunohistochemistry was used to investigate the significance tumor-infiltrating lymphocytes (TILs) breast cancer patients. Of 100 specimens obtained from primary invasive...
The aim was to further characterize immunoglobulin G4-related disease (IgG4-RD) by a large-scale multicenter study of its clinical and laboratory features conducted multidisciplinary physicians IgG4-RD in Japan.Various specialists retrospectively evaluated patients diagnosed between 1996 2015 five hospitals analyzing their baseline features, laboratory, imaging, pathological test findings, treatment.Of the 334 listed, 205 were male median age at diagnosis 65 years. mean number organs...
Objective Takayasu arteritis (TAK) is a systemic vasculitis affecting large arteries and branches of the aorta. Ulcerative colitis (UC) prevalent autoimmune colitis. Since TAK UC share HLA–B*52:01 IL12B as genetic determinants, since there are case reports co‐occurrence these diseases, we hypothesized that common complication TAK. We undertook this study to perform large‐scale analysis TAK, both evaluate prevalence concurrent cases identify estimate susceptibility genes shared between 2...