A5079198782- Cardiac Arrest and Resuscitation
- Traumatic Brain Injury and Neurovascular Disturbances
- Hemodynamic Monitoring and Therapy
- Non-Invasive Vital Sign Monitoring
- Optical Imaging and Spectroscopy Techniques
- Cardiac Ischemia and Reperfusion
- Thermal Regulation in Medicine
- Sepsis Diagnosis and Treatment
- Trauma and Emergency Care Studies
- Respiratory Support and Mechanisms
- Anesthesia and Neurotoxicity Research
- Heart Rate Variability and Autonomic Control
- Mitochondrial Function and Pathology
- Renal and Vascular Pathologies
- Venous Thromboembolism Diagnosis and Management
- Central Venous Catheters and Hemodialysis
- Injury Epidemiology and Prevention
- Pneumothorax, Barotrauma, Emphysema
- COVID-19 Clinical Research Studies
- Poisoning and overdose treatments
- Hydrogen's biological and therapeutic effects
- Renal Transplantation Outcomes and Treatments
- Pancreatitis Pathology and Treatment
- COVID-19 and healthcare impacts
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Northwell Health
2020-2025
Feinstein Institute for Medical Research
2020-2025
Osaka University
2016-2025
Kobe University
2024
North Shore University Hospital
2020-2023
Osaka University Hospital
2021
Osaka Gakuin University
2018-2019
Saitama International Medical Center
2010
P001 - Sepsis impairs the capillary response within hypoxic capillaries and decreases erythrocyte oxygen-dependent ATP efflux R. M. Bateman, D. Sharpe, J. E. Jagger, C. G. Ellis P002 Lower serum immunoglobulin G2 level does not predispose to severe flu. Solé-Violán, López-Rodríguez, Herrera-Ramos, Ruíz-Hernández, L. Borderías, Horcajada, N. González-Quevedo, O. Rajas, Briones, F. Rodríguez de Castro, Gallego P003 Brain protective effects of intravenous through inhibition complement...
Abstract Background Mitochondrial transplantation (MTx) is an emerging but poorly understood technology with the potential to mitigate severe ischemia–reperfusion injuries after cardiac arrest (CA). To address critical gaps in current knowledge, we test hypothesis that MTx can improve outcomes CA resuscitation. Methods This study consists of both vitro and vivo studies. We initially examined migration exogenous mitochondria into primary neural cell culture vitro. Exogenous extracted from...
The aim of this study was to evaluate an association between nutritional biomarkers and prognosis in septic patients.We retrospectively searched the including serum albumin (Alb), total protein (TP), cholesterol (T-chol), cholinesterase (ChE), for patients treated ICU >7 days. We used time-dependent Cox proportional hazard regression analysis resolve difference statistical weight each day's data all 14 consecutive days among individual sepsis patients. covariates were based on minimum moving...
We compared the outcome of COVID-19 in immunosuppressed solid organ transplant (SOT) patients to a naïve population. In total, 10 356 adult hospital admissions for from March 1, 2020 April 27, were analyzed. Data collected on demographics, baseline clinical conditions, medications, immunosuppression, and course. Primary was combined death or mechanical ventilation. assessed association between primary prognostic variables using bivariate multivariate regression models. also endpoint SOT an...
Pyrethroid insecticides are widely used because of their low toxicity in humans. Spray-type pyrethroids often formulated with kerosene as a carrier solvent, and inhalation kerosene-containing products can lead to pneumonitis the formation lung abscesses. We report case chemical resulting development abscess due intentional pyrethroids. A man his 50s psychiatric hospital for transient psychotic disorder attempted suicide during an overnight leave from hospital. He drank sodium hypochlorite,...
BackgroundCerebral oximetry (rSO2) may be useful in assessing the probability of return spontaneous circulation (ROSC). However, potential trend rSO2 value has not been discussed when determining ROSC.MethodsThis was a retrospective study out-of-hospital cardiac arrest (OHCA) patients with continuous values recorded during cardiopulmonary arrest. We used logistic regression analysis at each time point to investigate best subsets rSO2-related variables for ROSC, which included (baseline),...
Abstract Cardiac arrest (CA) patients suffer from systemic ischemia–reperfusion (IR) injury leading to multiple organ failure; however, few studies have focused on tissue-specific pathophysiological responses IR-induced oxidative stress. Herein, we investigated biological and physiological parameters of the brain heart, particularly lung dysfunction that has not been well studied date. We aimed understand susceptibility stress tested how oxygen concentrations in post-resuscitation setting...
Hyperglycemia is a common response to acute illness, but it not often seen in critical conditions. The frequency and cause of hypoglycemia septic patients have been well elucidated. In this study, we focused on sepsis-associated the early phase evaluated impact mortality.We performed retrospective review 265 with sepsis admitted tertiary medical center. Blood glucose levels admission were analyzed by Cox proportional hazard model.We categorized into five groups according blood levels. Seven...
Objective Cardiac arrest (CA) is a major health burden with brain damage being significant contributor to mortality. We found lysophosphatidylcholine (LPC), including species containing docosahexaenoic acid (LPC‐DHA), was significantly decreased in plasma post‐CA, supplementation of which improved neurological outcomes. The aim this study understand the protective role LPC‐DHA on post‐CA. Methods first evaluated associations between level and injury outcomes human patients CA. then utilized...
Deep vein thrombosis (DVT) is a major complication in critical care. There are various methods of prophylaxis, but none them fully prevent DVT, and each method has adverse effects. Electrical muscle stimulation (EMS) could be new effective approach to DVT intensive care unit (ICU) patients. We hypothesized that EMS increases the venous flow lower limbs prophylactic effect against formation DVT. This study included 26 patients admitted single ICU. enrolled who not move themselves due spinal...
Abstract Cardiac arrest (CA) and concomitant post‐CA syndrome lead to a lethal condition characterized by systemic ischemia–reperfusion injury. Oxygen (O 2 ) supply during cardiopulmonary resuscitation (CPR) is the key success in resuscitation, but sustained hyperoxia can produce toxic effects post CA. However, only few studies have investigated optimal duration dosage of O administration. Herein, we aimed determine whether high concentrations at are beneficial or harmful. After rats were...
Bicycle accidents are one of the major causes unintentional traumatic injury in childhood. The purpose this study was to examine characteristics and risks handlebar We conducted a more than 5-year retrospective survey patients under 15 years age with bicycle-related injuries admitted eight urban tertiary emergency centers Osaka, Japan. Patients were divided into direct-impact (HI) group non-handlebar (NHI) group. HI included 18 NHI 308 patients. Median Injury Severity Score (ISS) 9. sites...
Despite the benefits of extracorporeal cardiopulmonary resuscitation (ECPR) in cohorts selected patients with cardiac arrest (CA), membrane oxygenation (ECMO) includes an artificial and circuits that contact circulating blood induce excessive oxidative stress inflammatory responses, resulting coagulopathy endothelial cell damage. There is currently no pharmacological treatment has been proven to improve outcomes after CA/ECPR. We aimed test hypothesis administration hydrogen gas (H2)...
This prospective observational single-center cohort study aimed to determine an association between cerebrovascular autoregulation (CVAR) and outcomes in hypoxic-ischemic brain injury post-cardiac arrest (CA), assessed 100 consecutive post-CA patients Japan June 2017 May 2020 who experienced a return of spontaneous circulation. Continuous monitoring was performed for 96 h CVAR presence. A moving Pearson correlation coefficient calculated from the mean arterial pressure cerebral regional...
OBJECTIVES: Cardiac arrest and subsequent resuscitation have been shown to deplete plasma phospholipids. This depletion of phospholipids in circulating may contribute organ damage postresuscitation. Our aim was identify the diminishment essential postresuscitation develop a novel therapeutic approach supplementing these depleted that are required prevent dysfunction postcardiac arrest, which lead improved survival. DESIGN: Clinical case control study followed by translational laboratory...
We previously developed a risk assessment tool to predict outcomes after heat-related illness (J-ERATO score), which consists of six binary prehospital vital signs. aimed evaluate the ability score clinical for hospitalized patients with illnesses. In nationwide, prospective, observational study, adult illnesses were registered. A logistic regression model and receiver operating characteristic (ROC) curve analysis used assess relationship between J-ERATO survival at hospital discharge as...
Background: Cardiac arrest (CA) can lead to neuronal degeneration and death through various pathways, including oxidative, inflammatory, metabolic stress. However, current neuroprotective drug therapies will typically target only one of these most single attempts correct the multiple dysregulated pathways elicited following cardiac have failed demonstrate clear benefit. Many scientists opined on need for novel, multidimensional approaches disturbances after arrest. In study, we developed a...
This case series reviews four critically ill patients infected with severe acute respiratory syndrome coronavirus 2 (SARS - CoV 2) [coronavirus disease 2019 (COVID-19)] suffering from pneumatosis intestinalis (PI) during their hospital admission. All received the biological agent tocilizumab (TCZ), an interleukin (IL)-6 antagonist, as experimental treatment for COVID-19 before developing PI. and TCZ have been independently linked to PI risk, yet cause of this relationship is unknown under...
Abstract Background Despite much evidence supporting the monitoring of divergence transcutaneous partial pressure carbon dioxide (tcPCO 2 ) from arterial (artPCO as an indicator shock status, data are limited on relationships gradient between tcPCO and artPCO (tc-artPCO with systemic oxygen metabolism hemodynamic parameters. Our study aimed to test hypothesis that tc-artPCO can detect inadequate tissue perfusion during hemorrhagic resuscitation. Methods This prospective animal was performed...