A5042293459- Cardiac Arrest and Resuscitation
- Cardiac Ischemia and Reperfusion
- Traumatic Brain Injury and Neurovascular Disturbances
- Heart Rate Variability and Autonomic Control
- Mitochondrial Function and Pathology
- Neuroscience of respiration and sleep
- Metabolomics and Mass Spectrometry Studies
- Anesthesia and Neurotoxicity Research
- Thermal Regulation in Medicine
- Eicosanoids and Hypertension Pharmacology
- Intensive Care Unit Cognitive Disorders
- Sleep and Wakefulness Research
- Heme Oxygenase-1 and Carbon Monoxide
- Topic Modeling
- Fatty Acid Research and Health
- Pneumothorax, Barotrauma, Emphysema
- Hydrogen's biological and therapeutic effects
- S100 Proteins and Annexins
- Pancreatitis Pathology and Treatment
- Advanced Steganography and Watermarking Techniques
- Advanced Text Analysis Techniques
- Chaos-based Image/Signal Encryption
- Advanced Glycation End Products research
- Natural Language Processing Techniques
- Vagus Nerve Stimulation Research
Feinstein Institute for Medical Research
2019-2024
Northwell Health
2019-2024
University of Cincinnati
2021-2024
Osh State University
2024
North Shore University Hospital
2021-2023
IPS Academy
2023
ABES Engineering College
2022
University of California, Berkeley
2020-2022
Gyan Vihar University
2018
Osmania University
2018
Machine learning is an area of computer science in which the predicts next task to perform by analyzing data provided it. The accessed can be form digitized training sets or via interaction with environment. algorithms machine are constructed such a way as learn and make predictions from unlike static programming that need explicit human instruction. There have been different supervised unsupervised techniques proposed order solve problems, as, Rule-based techniques, Logic-based...
Abstract Background Mitochondrial transplantation (MTx) is an emerging but poorly understood technology with the potential to mitigate severe ischemia–reperfusion injuries after cardiac arrest (CA). To address critical gaps in current knowledge, we test hypothesis that MTx can improve outcomes CA resuscitation. Methods This study consists of both vitro and vivo studies. We initially examined migration exogenous mitochondria into primary neural cell culture vitro. Exogenous extracted from...
The human brain possesses three predominate phospholipids, phosphatidylcholine (PC), phosphatidylethanolamine (PE) and phosphatidylserine (PS), which account for approximately 35–40%, 20% of the brain’s respectively. Mitochondrial membranes are relatively diverse, containing aforementioned PC, PE, PS, as well phosphatidylinositol (PI) phosphatidic acid (PA); however, cardiolipin (CL) phosphatidylglycerol (PG) exclusively present in mitochondrial membranes. These phospholipid interactions...
In this article, a novel technique about secure medical information transmission of patient inside cover image is presented by concealing data using decision tree concept. Decision shows robust mechanism providing decisions for secret location in carrier mapping RSA encryption algorithm being used patient's unique enciphering. The outcome the structured into various equally distributed blocks. steganography, cipher blocks are assigned to inserting breadth first search. Receiver gets hidden...
In this article, we have proposed an improved diagonal queue medical image steganography for patient secret data transmission using chaotic standard map, linear feedback shift register, and Rabin cryptosystem, improvement of previous technique (Jain Lenka in Springer Brain Inform 3:39–51, 2016). The algorithm comprises four stages, generation pseudo-random sequences (pseudo-random are generated by register map), permutation XORing sequences, encryption the queues. Security analysis has been...
Abstract Cardiac arrest (CA) is a leading cause of death and there necessity for animal models that accurately represent human injury severity. We evaluated rat model severe CA by comparing plasma metabolic alterations to patients. Plasma was obtained from adult control patients post-resuscitation, male Sprague–Dawley rats at baseline after 20 min followed 30 cardiopulmonary bypass resuscitation. An untargeted metabolomics evaluation using UPLC-QTOF-MS/MS performed metabolome comparison....
Objective Cardiac arrest (CA) is a major health burden with brain damage being significant contributor to mortality. We found lysophosphatidylcholine (LPC), including species containing docosahexaenoic acid (LPC‐DHA), was significantly decreased in plasma post‐CA, supplementation of which improved neurological outcomes. The aim this study understand the protective role LPC‐DHA on post‐CA. Methods first evaluated associations between level and injury outcomes human patients CA. then utilized...
Abstract Cardiac arrest (CA) and concomitant post‐CA syndrome lead to a lethal condition characterized by systemic ischemia–reperfusion injury. Oxygen (O 2 ) supply during cardiopulmonary resuscitation (CPR) is the key success in resuscitation, but sustained hyperoxia can produce toxic effects post CA. However, only few studies have investigated optimal duration dosage of O administration. Herein, we aimed determine whether high concentrations at are beneficial or harmful. After rats were...
Cardiac arrest (CA) produces global ischemia/reperfusion injury resulting in substantial multiorgan damage. There are limited efficacious therapies to save lives despite CA being such a lethal disease process. The small population of surviving patients suffer extensive brain damage that results morbidity. Mitochondrial dysfunction most organs after has been implicated as major source injury. Metformin, first-line treatment for diabetes, shown promising the other diseases and is known...
Vagus nerve stimulation (VNS) has shown therapeutic potential in a variety of different diseases with many ongoing clinical trials. The role VNS reducing ischemic injury the brain requires further evaluation. Cardiac arrest (CA) causes global ischemia and leads to vital organs, especially brain. In this study, we investigated protective effects customized threshold-adjusted (tVNS) rat model CA resuscitation.
We present the results of an ongoing collaboration between computer science and psychology researchers that employs Natural Language Processing (NLP) methods to examine trajectory semantic space used during group idea generation sessions. Specifically, we track estimate region being degree which new ideas expand space. a visualization this mapping endeavor compare human ratings creativity dimensions (i.e., novelty, task-relevance, elaboration) algorithm-based estimations those same...
Despite the benefits of extracorporeal cardiopulmonary resuscitation (ECPR) in cohorts selected patients with cardiac arrest (CA), membrane oxygenation (ECMO) includes an artificial and circuits that contact circulating blood induce excessive oxidative stress inflammatory responses, resulting coagulopathy endothelial cell damage. There is currently no pharmacological treatment has been proven to improve outcomes after CA/ECPR. We aimed test hypothesis administration hydrogen gas (H2)...
The close interaction between neurons and astrocytes has been extensively studied. However, the specific behavior of these cells after ischemia-reperfusion injury hypothermia remains poorly characterized. A growing body evidence suggests that mitochondria function putative transference may play a fundamental role in adaptive homeostatic responses systemic insults such as cardiac arrest, which highlights importance better understanding how behave individually settings. Brain is one most...
Abstract Background Cardiac arrest (CA) results in loss of blood circulation to all tissues leading oxygen and metabolite dysfunction. Return flow during resuscitative efforts is the beginning reperfusion injury marked by generation reactive species (ROS) that can directly damage tissues. The plasma serves as a reservoir transportation medium for metabolites critical survival well ROS are generated. However, complicated interplay among various antioxidant counterparts, particularly after CA,...
OBJECTIVES: Cardiac arrest and subsequent resuscitation have been shown to deplete plasma phospholipids. This depletion of phospholipids in circulating may contribute organ damage postresuscitation. Our aim was identify the diminishment essential postresuscitation develop a novel therapeutic approach supplementing these depleted that are required prevent dysfunction postcardiac arrest, which lead improved survival. DESIGN: Clinical case control study followed by translational laboratory...
Ovarian cancer remains a highly lethal disease due to its late clinical presentation and lack of reliable early biomarkers. Protein-based diagnostic markers have presented limitations in identifying ovarian cancer. We tested the potential phospholipids as by utilizing inter-related regulation phospholipids, unique property that allows use ratios between phospholipid species for quantitation. High-performance liquid chromatography mass spectrometry was used measure phospholipid,...
Background: Cardiac arrest (CA) can lead to neuronal degeneration and death through various pathways, including oxidative, inflammatory, metabolic stress. However, current neuroprotective drug therapies will typically target only one of these most single attempts correct the multiple dysregulated pathways elicited following cardiac have failed demonstrate clear benefit. Many scientists opined on need for novel, multidimensional approaches disturbances after arrest. In study, we developed a...
This case series reviews four critically ill patients infected with severe acute respiratory syndrome coronavirus 2 (SARS - CoV 2) [coronavirus disease 2019 (COVID-19)] suffering from pneumatosis intestinalis (PI) during their hospital admission. All received the biological agent tocilizumab (TCZ), an interleukin (IL)-6 antagonist, as experimental treatment for COVID-19 before developing PI. and TCZ have been independently linked to PI risk, yet cause of this relationship is unknown under...