A5022231578- Sleep and Wakefulness Research
- Circadian rhythm and melatonin
- Sleep and related disorders
- Neuroscience and Neuropharmacology Research
- Neuroscience of respiration and sleep
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neuroendocrine regulation and behavior
- Neuroscience and Music Perception
- Tracheal and airway disorders
- Olfactory and Sensory Function Studies
- IL-33, ST2, and ILC Pathways
- Obstructive Sleep Apnea Research
- Hearing, Cochlea, Tinnitus, Genetics
- Ophthalmology and Eye Disorders
- Sepsis Diagnosis and Treatment
- Neurotransmitter Receptor Influence on Behavior
- Neurogenesis and neuroplasticity mechanisms
- Memory and Neural Mechanisms
- Educational Methods and Media Use
- Hemispheric Asymmetry in Neuroscience
- Stress Responses and Cortisol
- Regulation of Appetite and Obesity
- Pediatric health and respiratory diseases
- Hearing Loss and Rehabilitation
- Neuropeptides and Animal Physiology
Beth Israel Deaconess Medical Center
2018-2025
Harvard University
2020-2025
Hadassah Medical Center
2022-2024
Jawaharlal Nehru University
2012-2019
Sher-i-Kashmir Institute of Medical Sciences
2016
Abstract During obstructive sleep apnea, elevation of CO 2 during apneas contributes to awakening and restoring airway patency. We previously found that glutamatergic neurons in the external lateral parabrachial nucleus (PBel) containing calcitonin gene related peptide (PBel CGRP neurons) are critical for causing arousal hypercapnia. However, others genetic deletion serotonin (5HT) brainstem also prevented from To examine interactions between two systems, we showed dorsal raphe (DR) 5HT...
Many neurodegenerative disorders are associated with rapid eye movement sleep (REMS)-loss, however the mechanism was unknown. As REMS-loss elevates noradrenaline (NA) level in brain as well induces neuronal apoptosis and degeneration, this study we have delineated intracellular molecular pathway involved REMS deprivation (REMSD) NA-induced apoptosis. Rats were deprived for 6 days by classical flower-pot method, suitable controls conducted effects on markers evaluated. Further, role of NA...
ABSTRACT The parabrachial nucleus (PB), located in the dorsolateral pons, contains primarily glutamatergic neurons that regulate responses to a variety of interoceptive and cutaneous sensory signals. One lateral PB subpopulation expresses Calca gene, which codes for neuropeptide calcitonin gene‐related peptide (CGRP). These /CGRP relay signals related threatening stimuli such as hypercarbia, pain, nausea, yet their inputs neurochemical identity are only partially understood. We mapped...
Normally, rapid eye movement sleep (REMS) does not appear during waking or non-REMS. Isolated, independent studies showed that elevated noradrenaline (NA) levels inhibit REMS and induce loss-associated cytomolecular, cytomorphological, psychosomatic changes associated symptoms. However, the source of NA its target in brain for regulation function health diseases remained to be confirmed vivo . Using tyrosine hydroxylase (TH)-siRNA virus-coated TH-shRNA normal freely moving rats, we...
<title>Abstract</title> The secretion of cortisol in humans and corticosterone (Cort) rodents follows a daily rhythm which is important readying the individual for active cycle impaired chronic depression. This orchestrated by suprachiasmatic nucleus (SCN) governs activity neurons paraventricular hypothalamus that produce corticotropin-releasing hormone (PVH<sup>CRH</sup> neurons). dorsomedial (DMH) serves as crucial intermediary, being innervated SCN both directly via relays...
Abstract Introduction The lateral Hypothalamic area (LH) has been established as a critical site for regulating wakefulness. However, the exact neural elements within this region that promote and stabilize wakefulness are not completely understood. While orexin neurons in LH well-known, other subpopulations may also contribute to arousal control. In regard, we have recently identified subset of expressing neurotensin (Nts) promoting Optogenetic activation LH-Nts rapidly induces from...
Background: Emergence of newer culture methods and other diagnostic aids for neonatal sepsis makes evaluation known markers imperative to define their changing role. This study was designed assess role CRP, leukopenia, neutropenia thrombocytopenia in this era. Methods: A prospective observational conducted a level-3 NICU north India 2013. Study duration 1 year. All patients visiting our hospital with non-specific symptoms signs suggestive were admitted evaluated. Neonates confirmed allotted...
Serotoninergic dorsal (DRSert) and medullary raphe neurons are CO2 responsive, mice lacking these have impaired arousal to CO2. However, responsiveness can be restored by a 5HT2A agonist, suggesting that they modulatory. Recently, we showed the external lateral parabrachial nucleus containing calcitonin gene related peptide (PBelCGRP) required for hypercapnia-induced arousal. PBelCGRP also receive serotoninergic innervation from DRSert. We therefore hypothesize DRsert mediate its input PBel....