A5076817789- Cardiac Arrest and Resuscitation
- Cardiac Ischemia and Reperfusion
- Blood Coagulation and Thrombosis Mechanisms
- Mitochondrial Function and Pathology
- Cardiac tumors and thrombi
- Protease and Inhibitor Mechanisms
- Anesthesia and Neurotoxicity Research
- Atherosclerosis and Cardiovascular Diseases
- Myasthenia Gravis and Thymoma
- Sarcoma Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Peptidase Inhibition and Analysis
- Cancer Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Mechanical Circulatory Support Devices
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Pancreatic and Hepatic Oncology Research
- Ovarian cancer diagnosis and treatment
- Respiratory Support and Mechanisms
- Ultrasound in Clinical Applications
- Treatment of Major Depression
- Blood properties and coagulation
- Ear Surgery and Otitis Media
- Inflammatory Myopathies and Dermatomyositis
- Pharmacological Effects of Natural Compounds
Feinstein Institute for Medical Research
2023-2025
Northwell Health
2023-2025
University of Miyazaki
2015-2025
Case Western Reserve University
2024
Osaka University of Pharmaceutical Sciences
2021
Nayoro City General Hospital
2020
Osaka Medical and Pharmaceutical University
2017-2020
University of Miyazaki Hospital
2016-2019
The Nakamura Hajime Eastern Institute
2016
Osaka Kaisei Hospital
2013
Abstract Background Mitochondrial transplantation (MTx) is an emerging but poorly understood technology with the potential to mitigate severe ischemia–reperfusion injuries after cardiac arrest (CA). To address critical gaps in current knowledge, we test hypothesis that MTx can improve outcomes CA resuscitation. Methods This study consists of both vitro and vivo studies. We initially examined migration exogenous mitochondria into primary neural cell culture vitro. Exogenous extracted from...
The thrombogenic potential of cells within atherosclerotic plaques is critical in the formation a coronary thrombus. We hypothesized that combination inflammatory and hypoxic stimuli enhances tissue factor (TF) expression glycolysis contributes to thrombus formation. To identify TF- hexokinase (HK)-II-expressing thrombi determine effects combined on TF peripheral blood mononuclear cell-derived macrophages. immunohistochemically assessed HK-II stable (n = 20) unstable 24) human aspirated...
Patients with peripheral artery disease (PAD) have a high prevalence of cardiovascular morbidity and mortality; however, majority patients PAD are asymptomatic. This study aimed to histologically evaluate whether asymptomatic, lower extremity plaques associated systemic atherosclerosis the onset (CVD) events using autopsy cases.We investigated atherosclerotic common iliac, carotid, coronary, renal arteries from 121 cases without symptoms (mean age:67.6 years; 63% men; 83% non-CVD death). We...
Background Cardiac arrest (CA) is a significant public health concern. There the high imminent mortality and survival in those who are resuscitated substantively compromised by post-CA syndrome (PCAS), characterized multiorgan ischemia–reperfusion injury (IRI). The inflammatory response PCAS complex involves various immune cell types, including lymphocytes myeloid cells that have been shown to exacerbate organ IRI, such as myocardial infarction. Purinergic signaling, regulated CD39 CD73, has...
Summary We report a case of rapid pleural effusion after discontinuation lenvatinib. A 73-year-old woman was diagnosed with poorly differentiated thyroid cancer right metastasis. Weekly paclitaxel treatment performed for 18 weeks, but it not effective. Oral administration lenvatinib, multi-target tyrosine kinase inhibitor, reduced the size cervical and thoracic tumors lowered serum thyroglobulin levels. Lenvatinib discontinued on day 28 because Grade 2 thrombocytopenia 3 petechiae. Seven...
Inflammation and hypertension contribute to the progression of atherosclerotic aneurysm in aorta. Vascular cell metabolism is regarded modulate atherogenesis, but metabolic alterations that occur remain unknown. The present study aimed identify pathways metabolites aneurysmal walls examine their roles atherogenesis.Gene expression using microarray metabolite levels early lesions obtained from 42 patients undergoing aortic surgery were investigated (early lesion n=11, n=35) capillary...
Plaque erosion, a type of coronary atherothrombosis, involves superficial injury to smooth muscle cell (SMC)-rich plaques. Elevated levels coagulation factor VIII (FVIII) correlate with an increased ischemic heart disease risk. FVIII may contribute thrombus formation on eroded
Ovarian seromucinous borderline tumors (SMBTs) are rare. They architecturally resemble serous but much more frequently associated with endometriosis. The coexistence of other is also extremely Here, we report an unusual combination bilateral ovarian SMBT and clear cell carcinoma polypoid endometriosis the colon, in a 62-year-old woman. There was no transitional lesion between two tumors. Immunohistochemistry showed different staining patterns tumor components. Seromucinous cells were...
Abstract Background Previous clinical studies have reported that Shakuyaku‐kanzo‐to (SKT) has a therapeutic effect on muscle cramps, but few clarified how SKT acts to treat cramps. The aim of this study was perform an updated systematic review trials for in patients with Methods literature systematically reviewed assess the effects PubMed, Web Science, Cochrane Library, Google Scholar, and Ichushi‐Web were searched using terms “Shakuyaku‐kanzo‐to” (“shakuyakukanzoto”, etc), “clinical trials”...
Clostridium perfringens can cause various infections, including food poisoning, gas gangrene, cellulitis and fasciitis. C. septicemia is rare, but a known of hemolysis by damaging red blood cell, often proves rapidly fatal in emergency department (ED) situations. A previously healthy 76-year-old man presented to the ED 8 h after onset acute abdominal pain diarrhea. Laboratory examination revealed large discrepancy between cell count 1.91 × 106/mm3 hemoglobin level 10.3 g/dL, suggesting...
Inflammatory activity and hypoxia in atherosclerotic plaques are associated with plaque instability thrombotic complications. Recent studies show that vascular cell metabolism affects atherogenesis thrombogenicity. This study aimed to identify the metabolites macrophage-rich unstable modulate serve as potential markers of instability. Atherosclerotic were induced by balloon injury iliofemoral arteries rabbits fed on a conventional or 0.5% cholesterol diet. At 3 months post-balloon injury,...
Abstract Dysgerminoma is a rare germ cell tumor, accounting for 1% to 2% of all malignant ovarian tumors. Here, we report case dysgerminoma diagnosed by aspiration cytology cervical lymph node. A 20‐year‐old woman presented with an abdominal mass and left swelling. CT revealed large pelvic along nodular lesion on the side neck. Fine needle (FNA) node showed atypical cells small lymphocytes. Immunocytochemical staining block material that these tumor were positive placental alkaline...
BCL10 was recently demonstrated to be a biomarker for pancreatic acinar cell carcinoma, but whether altered expression can detected in block specimens is unclear. Here, we report carcinoma with cytological findings that showed block. A 72‐year‐old man presented tumor and underwent endoscopic ultrasound‐fine needle aspiration (EUS‐FNA) additional passes performed preparation. The EUS‐FNA cytology loose cohesive clusters focal acinar‐ or gland‐like‐structures prominent nucleoli. preoperative...
The seasonal incidence of acute abdomens, such as appendicitis, is reportedly more common in summer but reported less frequently Asia. Additionally, variations the severity abdomens have been evaluated insufficiently. This study and Japan. retrospective observational used a multicenter database containing data from 42 hospitals We included all patients diagnosed with diverticulitis, cholecystitis, cholangitis between January 2011 December 2019. Baseline patient admission date, sequential...
Abstract Background Fibroblast activation protein-α (FAP), a type-II transmembrane serine protease, is expressed during wound healing, in cancer-associated fibroblasts, and chronic fibrosing diseases. However, its expression deep vein thrombus (DVT) remains unclear. Therefore, this study, we investigated FAP localization DVT. Methods First, pathologically accessed aspirated thrombi of patients with DVT (n=14), classifying thrombotic areas as follows; fresh, cellular lysis,...
Abstract Introduction The glossopharyngeal nerve is important for gas exchange in fish, but mammals concentration focused on the hypoglossal (Dewald et al, 2018). In present study, we hypothesize discharge pattern of activity (GPNA) will relate to 3-phase respiratory motor apparent vagal, hypoglossal, and phrenic nerves mammals. Methods We recorded GPNA from situ arterially perfused brainstem preparations juvenile rats (n=10) compared these data simultaneously (PNA), vagal (VNA), (HNA)...
Abstract Background and aims Neutrophil extracellular traps (NETs), fibrin, the von Willebrand factor (VWF) are present in acute coronary thrombotic plaques. However, presence extent of NETs, VWF early-to-unstable atherosclerotic lesions remain unclear. This study to determine neutrophils, formation during human atherogenesis. Methods Coronary sections from autopsy patients with non-cardiac death (n=5, 37 sections) ischemic heart diseases (n= 11, 65 were classified by atherosclerosis...