A5037314029- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Sleep and Wakefulness Research
- Sleep and related disorders
- High Altitude and Hypoxia
- Respiratory Support and Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Tracheal and airway disorders
- Sleep and Work-Related Fatigue
- Voice and Speech Disorders
- Airway Management and Intubation Techniques
- Heart Rate Variability and Autonomic Control
- Neonatal Respiratory Health Research
- Restless Legs Syndrome Research
- Cardiovascular and Diving-Related Complications
- Adipose Tissue and Metabolism
- Dysphagia Assessment and Management
- Asthma and respiratory diseases
- Non-Invasive Vital Sign Monitoring
- Hemoglobinopathies and Related Disorders
- Circadian rhythm and melatonin
- Olfactory and Sensory Function Studies
- Epilepsy research and treatment
- Regulation of Appetite and Obesity
- Cardiovascular Syncope and Autonomic Disorders
Case Western Reserve University
2016-2025
University Hospitals of Cleveland
2015-2025
Louis Stokes Cleveland VA Medical Center
2016-2025
University School
2010-2025
VA Northeast Ohio Healthcare System
2019-2024
University of Houston
2024
University Hospitals Cleveland Medical Center
2007-2019
University of Iowa
2018
Columbia University
2002-2018
University of British Columbia Hospital
2018
The American Academy of Sleep Medicine (AASM) Apnea Definitions Task Force reviewed the current rules for scoring respiratory events in 2007 AASM Manual Scoring and Associated Events to determine if revision was indicated. goals task force were (1) clarify simplify rules, (2) review evidence new monitoring technologies relevant (3) strive greater concordance between adult pediatric rules. cited by systematic reliability validity published studies that have appeared literature since...
Background: Although sleep apnea is common, it often goes undiagnosed in primary care encounters. Objective: To test the Berlin Questionnaire as a means of identifying patients with apnea. Design: Survey followed by portable, unattended studies subset patients. Setting: Five sites Cleveland, Ohio. Patients: 744 adults (of 1008 surveyed [74%]), whom 100 underwent studies. Measurements: items addressed presence and frequency snoring behavior, waketime sleepiness or fatigue, history obesity...
Obstructive sleep apnea is associated with considerable health risks. Although continuous positive airway pressure (CPAP) can mitigate these risks, effectiveness be reduced by inadequate adherence to treatment. We evaluated the clinical safety and of upper-airway stimulation at 12 months for treatment moderate-to-severe obstructive apnea. Using a multicenter, prospective, single-group, cohort design, we surgically implanted an device in patients who had difficulty either accepting or...
In this case-control family study of sleep-disordered breathing (SDB), we describe the distributions SDB and risk factors in African-Americans Caucasians. A total 225 622 Caucasians, ages 2 to 86 yr, recruited as members families with an individual known sleep apnea (85 index families) or neighborhood control (63 were studied overnight home sleep-study, questionnaires, physical measurements. subsample underwent cephalometry. Outcome measures respiratory disturbance (RDI) a binary variable...
A general model is developed to account for all kinds of periodic breathing (PB) resulting from instability in respiratory control: normals during sleep and on acute exposure high altitude, sleeping infants, patients with cardiovascular or neurologic lesions. It found that almost every case the ventilatory oscillation mediated predominantly by peripheral controller. System stability decreased hypoxia, hypercapnia, increased lung washout times, prolonged lung-chemoreceptor delays, controller...
Narcolepsy is caused by the loss of hypocretin/orexin neurons in hypothalamus, which likely result an autoimmune process. Recently, concern has been raised over reports narcolepsy northern Europe following H1N1 vaccination.The study a retrospective analysis onset subjects diagnosed Beijing, China (1998-2010). Self-reported month and year were collected from 629 patients (86% children). Graphical presentation, autocorrelations, chi-square, Fourier used to assess monthly variation onset....
Strollo, Patrick J. JR*; Soose, Ryan J.†; Maurer, Joachim T.‡; de Vries, Nico§; Cornelius, Jason‖; Froymovich, Oleg¶; Hanson, Ronald D.#; Padhya, Tapan A.**; Steward, David L.††; Boyd Gillespie, M.‡‡; Woodson, Tucker§§; Van Heyning, Paul H.‖‖; Goetting, Mark G.¶¶; Vanderveken, Oliver M.‖‖; Feldman, Neil##; Knaack, Lennart***; STROHL, Kingman P.††† for the STAR (Stimulation Therapy Apnea Reduction) Trial Group Author Information
The American Academy of Sleep Medicine Task Force on Respiratory Scoring reviewed the evidence that addresses: validity specific sensors in detecting airflow, tidal volume, oxyhemoglobin saturation, and CO2; reliability scoring approaches for quantifying sleep related breathing disorders (SRBD); using various definitions apnea hypopnea index (AHI) as assessed by strength consistency associations with several comorbidities (hypertension, cardiovascular disease, sleepiness, impaired quality...
Primary treatment of obstructive sleep apnea can be accompanied by a persistence excessive sleepiness despite adherence. Furthermore, effectiveness is limited poor Currently available pharmacologic options for the in this population are limited.
Objective To present 5‐year outcomes from a prospective cohort of patients with obstructive sleep apnea (OSA) who were treated upper airway stimulation (UAS) via unilateral hypoglossal nerve implant. Study Design A multicenter study. Setting Industry‐supported academic and clinical trial. Methods From 126 patients, 97 completed protocol, 71 consented to voluntary polysomnogram. Those having continuous positive pressure failure moderate severe OSA, body mass index <32 kg/m 2 , no...
Continuous positive airway pressure (CPAP) is considered the treatment of choice for obstructive sleep apnea (OSA), and studies have shown that there a correlation between patient adherence outcomes. Newer CPAP machines can track adherence, hours use, mask leak, residual apnea-hypopnea index (AHI). Such data provide strong platform to examine OSA outcomes in chronic disease management model. However, are no standards capturing data, scoring flow signals, or measuring how clinicians should...
Previous feasibility studies have shown that electrical stimulation of the hypoglossal nerve can improve obstructive sleep apnea (OSA). The current study examined safety and preliminary effectiveness a second generation device, Upper Airway Stimulation (UAS) system, identified baseline predictors for therapy success. Two consecutive open prospective studies. UAS systems were implanted in patients with moderate to severe OSA who failed or intolerant continuous positive airway pressure (CPAP)....
To describe the 36-month clinical and polysomnography (PSG) outcomes in an obstructive sleep apnea (OSA) cohort treated with hypoglossal cranial nerve upper airway stimulation (UAS). A multicenter prospective study. Industry-supported academic setting. Participants (n = 116) at 36 months from a of 126 implanted participants. were enrolled phase III trial evaluating efficacy UAS for moderated to severe OSA. Prospective included apnea-hypopnea index, oxygen desaturation other PSG measures,...
Section:ChooseTop of pageAbstract <<ContentsOverviewIntroductionMethodsHow Much Sleep Is Enough ...Sleep in ChildrenShort DurationLong DurationDrowsy DrivingSleep and OccupationSleep DisordersFuture Directions: Resear...ConclusionsReferencesCITING ARTICLES
Background Obstructive sleep apnoea (OSA) is a heterogeneous disorder, and improved understanding of physiologic phenotypes their clinical implications needed. We aimed to determine whether routine polysomnographic data can be used identify OSA (clusters) assess the associations between cardiovascular outcomes. Methods Cross-sectional longitudinal analyses multisite, observational US Veteran (n=1247) cohort were performed. Principal components-based clustering was features in OSA’s four...
Purpose. To identify and model the effects of sleep loss fatigue on resident–physicians' professional lives personal well-being. Method. In 2001–02, 149 residents at five U.S. academic health centers from six specialties (obstetrics–gynecology, emergency medicine, family internal pediatrics, surgery) were recruited for study. Residents all in good standing their programs. a mixed-methods design, focus groups consisted an average seven (range, three to 14) individuals same year training...
Elevated hemoglobin concentrations have been reported for high-altitude sojourners and Andean natives since early in the 20th century. Thus, reports that appeared 1970s describing relatively low concentration among Tibetan were unexpected. These suggested a hypothesis of population differences hematological response to hypoxia. A case quantitatively different responses one environmental stress would offer an opportunity study broad evolutionary question origin adaptations. However, many...
We describe, in Ethiopia, a third successful pattern of human adaptation to high-altitude hypoxia that contrasts with both the Andean “classic” (erythrocytosis arterial hypoxemia) and more recently identified Tibetan (normal venous hemoglobin concentration patterns. A field survey 236 Ethiopian native residents at 3,530 m (11,650 feet), 14–86 years age, without evidence iron deficiency, hemoglobinopathy, or chronic inflammation, found an average 15.9 15.0 g/dl for males females,...
Although questionnaires have been developed to assess symptoms of obstructive sleep apnea (OSA), their overall reliability and utility not established. We evaluated the ability a questionnaire identify increased activity (IAA) in 465 participants an epidemiologic study OSA. Subjects roommates each completed underwent in-home studies. Responses 56 questions about habits, sleepiness, daytime performance were analyzed with factor analysis, logistic regression, receiver-operator curves (ROCs)....