A5100446027- Cardiovascular Function and Risk Factors
- Hormonal Regulation and Hypertension
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiac Ischemia and Reperfusion
- Adipose Tissue and Metabolism
- Histone Deacetylase Inhibitors Research
- Mitochondrial Function and Pathology
- Cardiac Arrhythmias and Treatments
- Renin-Angiotensin System Studies
- Heart Failure Treatment and Management
- Cardiac Arrest and Resuscitation
- Acute Myocardial Infarction Research
- Cardiac Fibrosis and Remodeling
- Cardiac Imaging and Diagnostics
- Cardiomyopathy and Myosin Studies
- Blood Pressure and Hypertension Studies
- Venous Thromboembolism Diagnosis and Management
- Receptor Mechanisms and Signaling
- Heart Rate Variability and Autonomic Control
- Intracranial Aneurysms: Treatment and Complications
- Signaling Pathways in Disease
- Cardiovascular Disease and Adiposity
- Antiplatelet Therapy and Cardiovascular Diseases
- Diet and metabolism studies
Shanghai East Hospital
2023-2025
Jilin Jianzhu University
2025
Luoyang Central Hospital Affiliated to Zhengzhou University
2018-2024
Shanghai Jiao Tong University
2013-2024
First Affiliated Hospital of Wannan Medical College
2024
Capital Medical University
2014-2024
Suzhou Kowloon Hospital
2024
Beijing Tian Tan Hospital
2018-2024
Yueyang Hospital
2024
Handan College
2024
Primary treatment of obstructive sleep apnea can be accompanied by a persistence excessive sleepiness despite adherence. Furthermore, effectiveness is limited poor Currently available pharmacologic options for the in this population are limited.
The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an important target for vaccine and drug development. However, the rapid emergence variant strains with mutated S proteins has rendered many treatments ineffective. Cleavage by host proteases essential viral infection. Here, we discovered that contains two previously unidentified Cathepsin L (CTSL) cleavage sites (CS-1 CS-2). Both are highly conserved among all known SARS-CoV-2 variants. Our structural...
To investigate the associations of sleep duration, midday napping, quality, and change in duration with risk incident stroke subtypes.Among 31,750 participants aged 61.7 years on average at baseline from Dongfeng-Tongji cohort, we used Cox regression models to estimate hazard ratios (HRs) 95% confidence intervals (CIs) for stroke.Compared sleeping 7 <8 hours/night, those reporting longer (≥9 hours/night) had a greater total (hazard ratio [HR] 1.23; interval [CI] 1.07-1.41), while shorter (<6...
Irisin, a newly identified hormone, is critical to modulating body metabolism, thermogenesis and reducing oxidative stresses. However, whether irisin protects the heart against myocardial ischemia reperfusion (I/R) injury remains unknown. In this study, we determine effect of on I/R in Langendorff perfused cultured myocytes. Adult C57/BL6 mice were treated with (100 mg/kg) or vehicle for 30 min elicit preconditioning. The isolated hearts subjected followed by reperfusion. Left ventricular...
Abstract Muscle function loss is characterized as abnormal or completely lost muscle capabilities, and it can result from neurological disorders nerve injuries. The currently available clinical treatment to electrically stimulate the diseased muscles. Here, a self‐powered system of stacked‐layer triboelectric nanogenerator (TENG) multiple‐channel epimysial electrode directly muscles demonstrated. Then, two challenges regarding direct TENG stimulation are further investigated. For first...
The LACE index has been used to predict the risk of unplanned readmission within 30 days after hospital discharge in both medical and surgical patients. aim this study is validate accuracy using CHF This was a retrospective study. score calculated on each patient who admitted due an acute exacerbation. Operational clinical variables were collected from patients including basic characteristics, length hospitalization, comorbidities, number previous ED visits past 6 months before admission,...
Histone deacetylases are recently identified to act as key regulators for cardiac pathophysiology and metabolic disorders. However, the function of histone deacetylase (HDAC) in controlling performance Type II diabetes obesity remains unknown. Here, we determine whether HDAC inhibition attenuates high fat diet (HFD)-induced dysfunction improves features. Adult mice were fed with either HFD or standard chow food 24 weeks. Starting at 12 weeks, divided into four groups randomly, which sodium...
We conducted a randomized controlled trial among African-American patients attending primary-care provider visit to compare efficacy of computer-delivered tailored intervention increase colorectal cancer (CRC) screening (n ¼ 273) with non-tailored print material-an American Cancer Society brochure on CRC 283).Health Belief Model constructs were used develop messages and examined as outcomes.Analysis covariance models changes between knowledge health belief scores at baseline 1 week...
This study examined sustained co-delivery of vascular endothelial growth factor (VEGF), angiopoietin-1 and basic fibroblast (bFGF) encapsulated in angiogenic microspheres. These spheres were delivered to sites spinal cord contusion injury rats, their ability induce vessel formation, neural regeneration improve hindlimb motor function was assessed. At 2-8 weeks after injury, ELISA-determined levels VEGF, angiopoietin-1, bFGF significantly higher tissues rats that received microspheres than...
We investigated the effects of astaxanthin supplementation on egg quality, antioxidant capacity, and ovarian aging aged laying hens. Six groups 68-wk-old Hy-line brown hens with six replications each, fifteen chickens in each replicate were fed for 12 wk. The control group was a basal diet, positive diet supplemented 100 mg/kg vitamin E, experimental 15 mg/kg, 30 45 or 60 (Ax15, Ax30, Ax45, Ax60, respectively). results showed that accumulated yolks improved yolk color (P < 0.01) Haugh unit...
Cardiac troponin I (cTnI) is a phosphoprotein subunit of the troponin‐tropomyosin complex that thought to inhibit cardiac muscle contraction during diastole. To investigate contributions cTnI phosphorylation regulation, transgenic mice were created with sites mutated alanine. Activation protein kinase C (PKC) by perfusion hearts phorbol‐12‐myristate‐13‐acetate (PMA) or endothelin‐1 (ET‐1) inhibited maximum ATPase rate up 25 % and increased Ca 2+ sensitivity activity isometric tension 0.15...
Irisin is a recently identified myokine which brings increases in energy expenditure and contributes to the beneficial effects of exercise through browning white adipose tissues. However, its heart remains unknown. This study sought determine irisin on hypoxia/reoxygenation injury relationship with HDAC4. Wild type stable HDAC4-overexpression cells were generated from H9c2 cardiomyoblasts. HDAC4 overexpression wild exposed 24 hours hypoxia followed by one hour reoxygenation vitro presence or...
Critical tissues that undergo regeneration in periodontal tissue are of mesenchymal origin; thus, investigating the regulatory mechanisms underlying fate ligament stem cells could be beneficial for application regeneration. Nitric oxide (NO) regulates many biological processes developing embryos and adult cells. The present study was designed to investigate effects NO on function human (PDLSCs) as well elucidate molecular mechanisms. Immunofluorescent staining flow cytometry were used cell...
Irisin, a newly identified hormone and cardiokine, is critical for modulating body metabolism. New evidence indicates that irisin protects the heart against myocardial ischemic injury. However, whether enhances cardiac progenitor cell (CPC)-induced repair remains unknown. This study examines effect of on CPC-induced when these cells are introduced into infarcted myocardium. Nkx2.5+ CPC stable were isolated from mouse embryonic stem cells. Nkx2.5 + CPCs (0.5 × 10 6 ) reintroduced myocardium...
Abstract Background Induction therapy for acute myeloid leukemia (AML) is an anthracycline-based chemotherapy regimen. However, many patients experience a relapse or exhibit refractory disease (R/R). There urgent need more effective regimens to reverse anthracycline resistance in these patients. Methods In this paper, Twenty-seven R/R AML with consecutively received chidamide combination regimen as salvage at the Chinese PLA General Hospital. Results Of 27 who had one course of therapy, 13...
Background: Low voltage areas (LVAs) on left atrial (LA) mapping correlate with fibrosis. However, there is no uniform standard for the definition of LVAs, or techniques and rhythms, so that predictive value LVAs recurrence fibrillation (AF) uncertain. This study aimed to explore relationship between presence pre-ablation risk recurrent AF after catheter ablation. Methods: The databases PubMed, Embase, Web science, Cochrane library, Scopus, Wanfang Datebase, China National Knowledge...
The colon and rectum are highly innervated, with neural components within the tumor microenvironment playing a significant role in colorectal cancer (CRC) progression. While perineural invasion (PNI) is associated poor prognosis CRC, impact of nerve density diameter on behavior remains unclear. This study aims to evaluate prognostic value characteristics CRC verify nerves growth. Tissue samples from 129 patients were stained immunofluorescent markers NF-L S100B detect nerves. Nerve measured...
Abstract Perineural invasion (PNI), characterized by tumor cells surrounding and invading nerves, is associated with poor prognosis in colorectal cancer (CRC). Understanding the mechanisms of PNI crucial for developing targeted therapies to impede progression. In this study, clinical information transcriptome data are obtained from TCGA database. Stable MAGEA6 knockdown CRC cell lines established investigate impact on malignancy. Immunohistochemical staining used assess significance MAGEA6....
Considerable attention is focused on polymorphisms in the gene encoding transforming growth factor-beta1 (TGF-beta1), a multifunctional cytokine that turn potent inhibitor involved wound healing and differentiation. In humans, it promotes pathogenesis of organ fibrosis, atherosclerosis, cancer, autoimmune inflammatory diseases, keloid disease, hypertrophic scarring. For this reason, much emphasis has been placed studies elucidating impact TGF-beta1 its variations for susceptibility these...