A5101648107- Cancer-related Molecular Pathways
- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Radiation Therapy and Dosimetry
- Sleep and Wakefulness Research
- DNA Repair Mechanisms
- Effects of Radiation Exposure
- Pancreatic and Hepatic Oncology Research
- Monoclonal and Polyclonal Antibodies Research
- Discourse Analysis in Language Studies
- Viral Infections and Immunology Research
- Cancer Cells and Metastasis
- Renal Diseases and Glomerulopathies
- Cancer, Hypoxia, and Metabolism
- Viral Infections and Vectors
- Cell death mechanisms and regulation
- Parkinson's Disease Mechanisms and Treatments
- Hepatitis Viruses Studies and Epidemiology
- Renal and related cancers
- Mosquito-borne diseases and control
- Ubiquitin and proteasome pathways
- Restless Legs Syndrome Research
- Transcranial Magnetic Stimulation Studies
- TGF-β signaling in diseases
- Systemic Lupus Erythematosus Research
Rawalpindi Medical University
2022-2025
Liaquat University of Medical & Health Sciences
2024-2025
Holy Family Hospital
2022-2025
East Sussex Healthcare NHS Trust
2024
University of Miami
2010-2023
Dow University of Health Sciences
2022
Altoona Arthritis and Osteoporosis Center
2021
Mehran University of Engineering and Technology
2020
Cleveland Sleep Research Center
2015-2018
Mysore Medical College
2012
Primary treatment of obstructive sleep apnea can be accompanied by a persistence excessive sleepiness despite adherence. Furthermore, effectiveness is limited poor Currently available pharmacologic options for the in this population are limited.
Monkeypox that started spreading from central and western Africa has recently been detected in various countries including Spain, Canada, Australia, UAE. Though it a very low incidence rate, is still significant threat must be dealt with as quickly possible the probability of to many other high. It caused by virus belongs genus Orthopox also include smallpox virus, which quite similar clinical presentation Monkeypox. With fading immunity against Smallpox, important counter this newly...
Spatially Fractionated high dose (Grid) Radiation Treatment (SFGRT) involves irradiation of bulky tumors with one high, grid-delivered, 15 Gy followed by multiple consecutive doses 2 each. The goal this study is to determine the effect treatment on serum ceramide content and investigate possible involvement in tumor regression after SFGRT. Serum Secretory SMase (SSMase) were quantified 11 patients before at 24, 48 72 h Gy. Furthermore, LDL particles isolated from their apoptotic ability was...
Cheyne-Stokes respiration (CSR) in severe stable congestive heart failure (CHF) may be associated with significant nocturnal arterial oxygen desaturation and sleep disruption. Previous investigations of inhaled CO2 CSR have been uncontrolled short duration, has not monitored electroencephalographically, most patients studied had neurological disease or without cardiac disease. The purpose our study was to document the effects on CHF (left ventricular ejection fraction <35% NYHA class 3 4...
AbstractIn this study, we investigated the influence of bcl-2 overexpression on radiosensitizing potential Didox (DX; 3,4-Dihydroxybenzohydroxamic acid), a novel ribonucleotide reductase inhibitor, in p53-null prostate cancer cell line PC-3. The PC-3 cells were transfected with vector alone or ectopically overexpressed CMV-bcl-2 construct. effect radiation (IR) DX and combination (pre post IR exposure DX) survival was determined by colony-forming assay. impact these two treatments cycle flow...
The tumor suppressor protein p53 is a pivotal regulator of apoptosis, and prostate cancer cells that lack are moderately resistant to apoptotic death by ionizing radiation. Genes encoding the transcription factor <i>early growth response-1</i> (EGR-1) cytokine necrosis factor-α (TNF-α) were induced upon irradiation cells, inhibition EGR-1 function resulted in abrogation both TNF-α induction apoptosis. Induction gene radiation was mediated via GC-rich EGR-1-binding motif promoter. Because...
Exposure to ionizing radiation leads induction of the immediate-early gene, early growth response-1 (Egr-1). Previous studies have suggested distinct cell type- and inducer-specific roles for EGR-1 protein in cellular inhibition. The present study was undertaken determine functional role inhibition caused by exposure tumor cells radiation. human melanoma A375-C6. Inhibition either function stable transfection with a dominant-negative mutant or expression transient an antisense oligomer...
The current study was undertaken to investigate the influence of wild-type or mutant p53 status on radiosensitizing effect paclitaxel in colorectal tumor cell lines.HCT-116 (contains p53) and HT-29 established from moderately differentiated carcinomas were used this study. Colony-forming assay performed after exposure either different radiation doses (0.5-6 gray [Gy]) (1-10 nM) combination. Induction p21(waf1/cip1) by these treatments determined immunocytochemistry Western blot...
Multidrug resistance (MDR) is associated with the overproduction of 170-kDa transmembrane protein P-glycoprotein (MDR1) caused by transcriptional activation. However, activity MDR1 promoter in response to different doses ionizing radiation has not been investigated. In this study, two squamous cell carcinoma oral cavity lines, T-167 and T-409, were exposed either a standard clinical dose 2 Gy or low-dose fractionated therapy (LDFRT), delivered as 0.5 four fractions. gene expression degree...
This study examined the effects of milnacipran on polysomnographic (PSG) measures sleep and subjective complaints in patients with fibromyalgia disturbed sleep.
This article presents the case of a 52-year-old male who arrived at emergency department with escalating chest pain and shortness breath. An urgent CT scan revealed right pulmonary embolism inferior vena cava thrombus, prompting immediate anticoagulant therapy. Further diagnostic evaluations confirmed nephrotic syndrome (NS). The patient was discharged on apixaban, ramipril, amlodipine, atorvastatin. A subsequent renal biopsy showed features consistent minimal change disease, which resolved...
Chikungunya virus is no stranger to the Indian sub-continent.Since its first isolation in Calcutta [1] 1963, there have been several reports of chikungunya infection different parts India [2], [3], [4].The last outbreak occurred 1971.Subsequently has active or passive surveillance carried out country and therefore, it 'seemed' that had 'disappeared' from subcontinent [5] However, recent large scale outbreaks fever caused by Southern confirmed re-emergence this virus.It estimated over...