A5025584813- Obstructive Sleep Apnea Research
- Sleep and Wakefulness Research
- Neuroscience of respiration and sleep
- Sleep and related disorders
- Respiratory Support and Mechanisms
- Heart Rate Variability and Autonomic Control
- EEG and Brain-Computer Interfaces
- Non-Invasive Vital Sign Monitoring
- Sleep and Work-Related Fatigue
- Cardiovascular Syncope and Autonomic Disorders
- Circadian rhythm and melatonin
- Restless Legs Syndrome Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Tracheal and airway disorders
- Cardiovascular and Diving-Related Complications
- Nutritional Studies and Diet
- Cardiovascular Disease and Adiposity
- Neural dynamics and brain function
- Ocular and Laser Science Research
- Long-Term Effects of COVID-19
- High Altitude and Hypoxia
- Functional Brain Connectivity Studies
- Dysphagia Assessment and Management
- Voice and Speech Disorders
- Epilepsy research and treatment
Beth Israel Deaconess Medical Center
2016-2025
Harvard University
2014-2025
Hadassah Medical Center
2017-2024
Massachusetts General Hospital
2005-2024
Beth Israel Deaconess Hospital
2001-2024
Center for Pain and the Brain
2024
Harvard University Press
2009-2024
Athinoula A. Martinos Center for Biomedical Imaging
2005-2023
Hallym University Dongtan Sacred Heart Hospital
2023
Seoul National University Bundang Hospital
2021-2023
Primary treatment of obstructive sleep apnea can be accompanied by a persistence excessive sleepiness despite adherence. Furthermore, effectiveness is limited poor Currently available pharmacologic options for the in this population are limited.
Sleep disturbance is common in dementia, although it unclear whether differences sleep architecture precede dementia onset. We examined the associations between and prospective risk of incident community-based Framingham Heart Study (FHS).
To evaluate a new automated measure of cardiopulmonary coupling during sleep using single-lead electrocardiographic signal. Using training and test datasets 35 polysomnograms each, we assessed the correlations an electrocardiogram-based interactions with respect to standard staging, as well cyclic alternating pattern classification. The in 15 healthy individuals was also assessed. American Academy Sleep Medicine Accredited Disorders Center. None From continuous, electrocardiogram, extracted...
Functional magnetic resonance imaging was used to map cerebral activation in 16 patients with obstructive sleep-disordered breathing (OSDB) and healthy subjects, during the performance of a 2-back verbal working memory task. Six OSDB were reimaged after minimum period 8 wk treatment positive airway pressure. Working speed significantly slower than group average showed absence dorsolateral prefrontal activation, regardless nocturnal hypoxia. After treatment, resolution subjective sleepiness...
Obstructive sleep apnea (OSA) contributes to the development of systemic hypertension, and hypertension strongly predicts white matter change (WMC). Thus, it is plausible that OSA mediates WMC. The goal current study determine whether a contextual relationship exists between cerebral Cross-sectional analyses conducted in population-based study. Korean community-based sample from Genome Epidemiology Study (KoGES) who attended examinations 2011 at medical center. There were 503 individuals...
Complex sleep apnea is defined as disordered breathing secondary to simultaneous upper airway obstruction and respiratory control dysfunction. The objective of this study was assess the utility an electrocardiogram (ECG)-based cardiopulmonary coupling technique distinguish obstructive from central or complex apnea. Analysis archived polysomnographic datasets. A laboratory for computational signal analysis. None. PhysioNet Sleep Apnea Database, consisting 70 polysomnograms including...
Obstructive sleep apnea (OSA) is associated with atrial remodeling, fibrillation (AF), and increased incidence of arrhythmia recurrence after pulmonary vein (PV) isolation. We aimed to characterize the substrate, including AF triggers in patients paroxysmal OSA.In 86 (43 ≥moderate OSA [apnea-hypopnea index ≥15] 43 without <5]), right left voltage distribution, conduction velocities, electrogram characteristics were analyzed during pacing. examined before PV isolation targeted for ablation....
To test the hypothesis that excessive amyloid deposition is a biological link between obstructive sleep apnea (OSA) and Alzheimer’s disease, we determined whether OSA increases cerebral burden, relative to controls, using Pittsburgh Compound B (PiB) PET imaging. The subjects were adult participants (age 50–65 years) from Korean Genome Epidemiology Study. Polysomnography, brain MRI including 3D images, detailed neuro-cognitive function battery done in 2011–2012. Nineteen (Apnea–Hypopnea Index...
Abstract Study Objectives Sleep is reflected not only in the electroencephalogram but also heart rhythms and breathing patterns. We hypothesized that it possible to accurately stage sleep based on electrocardiogram (ECG) respiratory signals. Methods Using a dataset including 8682 polysomnograms, we develop deep neural networks from ECG Five consisting of convolutional long- short-term memory are trained using breathing, timing R peaks ECG, abdominal chest effort, combinations these Results...
To determine if weekend catch-up sleep (CUS) impacts body mass index (BMI) in the general population.A stratified random sample (2156 subjects; age 19-82 years old, 43.0 ± 14.5; 1183 male) from population was evaluated, 2010, using face-to-face interviews about sociodemographic characteristics, height, weight, habitual duration, and time-in-bed at night on weekdays weekend, sleep-related profiles, mood anxiety scales, comorbid-medical conditions. Weekend CUS identified when nocturnal...
Seizures and epilepsy in the elderly are an important increasingly common clinical problem. Major known causes include cerebrovascular disease, brain tumor, degenerative disorders such as Alzheimer disease cerebral amyloid angiopathy, toxic-metabolic syndromes nonketotic hyperglycemia, postcardiac arrest, drug-induced seizures. Recognition of seizures may be complicated by relatively unique presentations differential diagnosis. Nonconvulsive status epilepticus present recurrent episodes...
Introduction Enhanced characterization of sleep architecture, compared with routine polysomnographic metrics such as stage percentages and efficiency, may improve the predictive phenotyping fragmented sleep. One approach involves using transition analysis to characterize continuity. Methods Principal Findings We analyzed hypnograms from Sleep Heart Health Study (SHHS) participants following designations: wake after onset (WASO), non-rapid eye movement (NREM) sleep, REM show that individual...
Significance The carotid body (CB) is the major sensory organ responsible for monitoring arterial blood oxygen content. Glomus cells in CB express heme oxygenase 2 (HO-2) and cystathionine-γ-lyase (CSE), enzymes that generate gasotransmitters carbon monoxide (CO) hydrogen sulfide (H S), respectively. In normoxia, CO inhibits CSE from producing H S. During hypoxia, HO-2 produces less CO, resulting increased S production, which stimulates activity, leading to increases respiratory rate, heart...
To define the clinical and polysomnographic features of a distinct variant obstructive sleep-disordered breathing that is remarkably mild during rapid eye movement (REM) sleep.Observational study evaluation records.American Academy Sleep Medicine-accredited multidisciplinary sleep disorders center laboratory.35 medication-free subjects with severe selected for dominance 1 2 disordered patterns.Positive airway pressure titration.Nasal was used to score respiratory events. scored by both...