A5017168859- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Health, Environment, Cognitive Aging
- Cerebrovascular and Carotid Artery Diseases
- Neurobiology of Language and Bilingualism
- Machine Learning in Healthcare
- Traumatic Brain Injury Research
- Blood Pressure and Hypertension Studies
- Functional Brain Connectivity Studies
- Nutritional Studies and Diet
- Acute Ischemic Stroke Management
- Neurological Disease Mechanisms and Treatments
- Cardiovascular Health and Disease Prevention
- Genetic Associations and Epidemiology
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced Neuroimaging Techniques and Applications
- Cognitive Functions and Memory
- Frailty in Older Adults
- Diet and metabolism studies
- Technology Use by Older Adults
- Bioinformatics and Genomic Networks
- Folate and B Vitamins Research
- Cardiovascular Health and Risk Factors
- Health Systems, Economic Evaluations, Quality of Life
- Artificial Intelligence in Healthcare
Boston University
2016-2025
Framingham Heart Study
2016-2025
Intuit (United States)
2024-2025
National Heart Lung and Blood Institute
2011-2024
Alzheimer’s Disease Neuroimaging Initiative
2024
New York University
2022-2024
University of California, San Diego
2023
Landscape Research Group
2023
Authorised Association Consortium
2023
University School
1996-2023
Our aim was to test the association of vascular risk factor exposure in midlife with progression MRI markers brain aging and measures cognitive decline.A total 1,352 participants without dementia from prospective Framingham Offspring Cohort Study were examined. Multivariable linear logistic regressions implemented study longitudinal change white matter hyperintensity volume (WMHV), (TBV), temporal horn volume, logical memory delayed recall, visual reproductions delayed-recall (VR-d),...
To relate performance on tests of cognitive ability to the subsequent development probable Alzheimer disease (pAD) and identify pattern earliest changes in functioning associated with a diagnosis pAD.From May 1975 November 1979, screening neuropsychological battery was administered Framingham Study participants. They were followed up prospectively for 22 years examined at least every 2 pAD.A community-based center epidemiological research.Subjects 1076 participants aged 65 94 who free...
The lifetime risk (LTR) of stroke has not been reported for the United States population; such data would assist public education and health planning.Framingham Original cohort participants (n=4897) who were stroke- dementia-free at 55 years age followed biennially up to 51 (115 146 person years). We estimated sex-specific 10-, 20-, 30-year risks LTR developing a by baseline blood pressure (BP) compared it with Alzheimer disease (AD).A total 875 (522 women) developed first-ever stroke; 749...
Background: Docosahexaenoic acid (DHA) is an abundant fatty in the brain.In diet, DHA found mostly fish.The content of has been shown to be decreased brain and plasma patients with dementia.Objective: To determine whether phosphatidylcholine (PC) associated risk developing dementia.Design, Setting, Participants: A prospective follow-up study 899 men women who were free dementia at baseline, had a median age 76.0 years, followed up for mean 9.1 years development all-cause Alzheimer...
We compared two methods of diagnosing mild cognitive impairment (MCI): conventional Petersen/Winblad criteria as operationalized by the Alzheimer's Disease Neuroimaging Initiative (ADNI) and an actuarial neuropsychological method put forward Jak a
The term “repetitive head impacts” (RHI) refers to the cumulative exposure concussive and subconcussive events. Although RHI are believed increase risk for later-life neurological consequences (including chronic traumatic encephalopathy), quantitative analysis of this relationship has not yet been examined because lack validated tools quantify lifetime exposure. objectives study were: 1) develop a metric from football, which we “cumulative impact index” (CHII); 2) use CHII examine...
White matter hyperintensities and MRI-defined brain infarcts (BIs) have individually been related to stroke, dementia, mortality in population-based studies, mainly older people. Their significance middle-aged community-dwelling persons the relative importance of these associations remain unclear. We simultaneously assessed relation white BI with incident mild cognitive impairment, a community-based cohort.A total 2229 Framingham Offspring Study participants aged 62+/-9 years underwent...
<b>Objectives:</b> Depression may be associated with an increased risk for dementia, although results from population-based samples have been inconsistent. We examined the association between depressive symptoms and incident dementia over a 17-year follow-up period. <b>Methods:</b> In 949 Framingham original cohort participants (63.6% women, mean age = 79), were assessed at baseline (1990-1994) using 60-point Center Epidemiologic Studies Scale (CES-D). A cutpoint of ≥16 was used to define...
We estimated the remaining lifetime risks of developing Alzheimer9s disease (AD) and dementia from all causes, based on data longitudinal population studies. The risk AD during one9s depends both incidence life expectancy. Conventional estimates cumulative overestimate when there is a substantial probability mortality due to competing causes. A total 2,611 cognitively intact subjects (1,061 men, 1,550 women; mean age, 66± 7 years) were prospectively evaluated for development or other...
<b>Objective:</b> To examine whether serum cytokines and spontaneous production of peripheral blood mononuclear cell (PBMC) are associated with the risk incident Alzheimer disease (AD). <b>Methods:</b> We followed 691 cognitively intact community-dwelling participants (mean age 79 years, 62% women) related PBMC cytokine (tertiles interleukin 1 [IL-1], IL-1 receptor antagonist, tumor necrosis factor α [TNF-α]) C-reactive protein 6 (IL-6) to AD. <b>Results:</b> Adjusting for clinical...
<h3>Context</h3>The adipokine leptin facilitates long-term potentiation and synaptic plasticity in the hippocampus, promotes β-amyloid clearance, improves memory function animal models of aging Alzheimer disease (AD).<h3>Objective</h3>To relate baseline circulating concentrations a community-based sample individuals without dementia to incident AD during follow-up magnetic resonance imaging (MRI) measures brain survivors.<h3>Design, Setting, Participants</h3>Prospective study plasma measured...
Gender-specific risks for dementia and Alzheimer's disease (AD) starting in midlife remain largely unknown.Prospectively ascertained dementia/AD cause-specific mortality Framingham Heart Study (FHS) participants was used to generate 10- 50-year risk estimates of on the basis Kaplan-Meier method (cumulative incidence) or accounting competing death (lifetime [LTR]).Overall, 777 cases incident (601 AD) occurred 7901 (4333 women) over 136,266 person-years. Whereas cumulative incidences were...
<b>Objectives</b> To relate cancer since entry into the Framingham Heart Study with risk of incident Alzheimer’s disease and to estimate among participants without disease. <b>Design</b> Community based prospective cohort study; nested age sex matched case-control study. <b>Setting</b> Study, USA. <b>Participants</b> 1278 a history who were aged 65 or more free dementia at baseline (1986-90). <b>Main outcome measures</b> Hazard ratios 95% confidence intervals for risks cancer. <b>Results</b>...
<h3>Objective</h3> To examine the relationship between white matter hyperintensity (WMH) volume on magnetic resonance images and cognitive tests in a large, population-based sample. <h3>Methods</h3> Quantitative imaging neuropsychological evaluations were performed 1820 dementia- stroke-free participants from Framingham Offspring Cohort. The WMH relative to total cranial was computed; volumes more than 1 SD above age-predicted mean defined as large. Adjusting for age, sex, education, height,...
Background and Purpose— Identification of risk factors for dementia after stroke is best performed in comparison with stroke-free controls, because older subjects at high also have a substantial the absence stroke. Previous case-control studies were hospital-based. We used nested design to prospectively evaluate these community-based Framingham Study cohort. Methods— compared 212 who free January 1982 sustained first this date, 1060 age- sex-matched, stroke- dementia-free controls....
Alzheimer's disease is the primary cause of dementia worldwide, with an increasing morbidity burden that may outstrip diagnosis and management capacity as population ages. Current methods integrate patient history, neuropsychological testing MRI to identify likely cases, yet effective practices remain variably applied lacking in sensitivity specificity. Here we report interpretable deep learning strategy delineates unique signatures from multimodal inputs MRI, age, gender, Mini-Mental State...
Background and Purpose— Previous estimates of the prevalence silent cerebral infarction (SCI) on MRI in community-based samples have varied between 5.8% 17.7% depending age, ethnicity, presence comorbidities, imaging techniques. We document risk factors associated with SCI at midlife Framingham sample. Methods— Our study sample comprised 2040 Offspring (53% female; mean 62±9 years) who attended sixth examination (1996–1998), underwent volumetric brain (1999–2005,) were free clinical stroke...
Carotid atherosclerosis has been associated with increased risk of stroke and poorer cognitive performance in older adults. The relation carotid to impairment MRI indices ischemia aging midlife is less clear.We studied 1975 Framingham Offspring Study participants free dementia available ultrasound, brain MRI, neuropsychological testing. We related common internal artery intima-media thickness stenosis large white matter hyperintensity (>1 SD above age-specific mean), total volume,...