A5081258864- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Neurobiology of Language and Bilingualism
- Memory and Neural Mechanisms
- Functional Brain Connectivity Studies
- Health, Environment, Cognitive Aging
- Parkinson's Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Neural and Behavioral Psychology Studies
- Neurological Disease Mechanisms and Treatments
- Spatial Neglect and Hemispheric Dysfunction
- Memory Processes and Influences
- Frailty in Older Adults
- Neurological disorders and treatments
- Cognitive Functions and Memory
- Neurological Disorders and Treatments
- Language Development and Disorders
- Epilepsy research and treatment
- Cerebrovascular and Carotid Artery Diseases
- Cholinesterase and Neurodegenerative Diseases
- Health and Well-being Studies
- EEG and Brain-Computer Interfaces
- Visual perception and processing mechanisms
- Mental Health and Psychiatry
University of California, San Diego
2016-2025
Alzheimer’s Disease Neuroimaging Initiative
1991-2024
VA San Diego Healthcare System
1999-2021
Neurosciences Institute
2006-2021
Purdue University West Lafayette
2020
San Diego State University
1993-2020
Nagoya University
2020
Mayo Clinic in Florida
2020
Mayo Clinic
2020
Jacksonville University
2020
Based on the recent literature and collective experience, an international consortium developed revised guidelines for diagnosis of behavioural variant frontotemporal dementia. The validation process retrospectively reviewed clinical records compared sensitivity proposed earlier criteria in a multi-site sample patients with pathologically verified lobar degeneration. According to criteria, 'possible' dementia requires three six clinically discriminating features (disinhibition,...
Abstract We present here both linear regressions and multivariate analyses correlating three global neuropsychological tests with a number of structural neurochemical measurements performed on prospective series 15 patients Alzheimer's disease 9 neuropathologically normal subjects. The statistical data show only weak correlations between psychometric indices plaques tangles, but the density neocortical synapses measured by new immunocytochemical/densitometric technique reveals very powerful...
Thirty-six clinically diagnosed and pathologically confirmed Alzheimer9s disease (AD) patients included 13 with cortical subcortical Lewy bodies (LBs). The LBs appeared to constitute a distinct neuropathologic clinical subset of AD, the body variant (LBV). LBV group showed gross pallor substantia nigra, greater neuron loss in locus ceruleus, innominata, lower neocortical ChAT levels, fewer midfrontal tangles than did pure AD group, along high incidence medial temporal lobe spongiform...
Abstract We report the prevalence rates for dementia and Alzheimer's disease (AD) obtained from a probability sample survey of 5,055 noninstitutionalized older persons in Shanghai, China. A two‐stage procedure was used case finding identification. Chinese version Mini‐Mental State Examination to determine cases possible dementia. Three different cutoff points on this mental status test were depending respondent's level education. Clinical evaluations, based functional assessments psychiatric...
A new secondary prevention trial in older people with amyloid accumulation at high risk for Alzheimer’s disease dementia should provide insights into whether anti-amyloid therapy can delay cognitive decline.
The performances of 89 patients with dementia the Alzheimer type (DAT) and 53 demographically matched elderly normal control subjects were compared on four verbal fluency measures (category, letter, first names, supermarket fluency). Receiver operating characteristic curves plotted to determine each tasks' sensitivity (ie, true-positive rate) specificity true-negative rate). Category demonstrated greatest degree discrimination between DAT (sensitivity, 100%; specificity, 92.5%); letter was...
We compared two methods of diagnosing mild cognitive impairment (MCI): conventional Petersen/Winblad criteria as operationalized by the Alzheimer's Disease Neuroimaging Initiative (ADNI) and an actuarial neuropsychological method put forward Jak a
Abstract Episodic (recall of passages) and semantic (letter category fluency) memory tasks were administered to Alzheimer's Disease (early stages), Huntington's (HD), alcoholic Korsakoff patients matched for overall severity dementia. Although all three patient groups severely (and equally) impaired on passages, only the Alzheimer emitted numerous intrusion errors. On fluency tasks, performance mild was distinguishable from that other two groups. both HD demonstrated severe moderate...
The neuropsychological battery of the Uniform Data Set (UDSNB) was implemented in 2005 by National Institute on Aging (NIA) Alzheimer Disease Centers program to measure cognitive performance dementia and mild impairment due Disease. This paper describes a revision, UDSNB 3.0.
Memory loss in Alzheimer's disease (AD) is attributed to pervasive weakening and of synapses. Here, we present findings supporting a special role for excitatory synapses connecting pyramidal neurons the hippocampus cortex with fast-spiking parvalbumin (PV) interneurons that control network excitability rhythmicity. Excitatory on PV are dependent AMPA receptor subunit GluA4, which regulated by presynaptic expression synaptogenic immediate early gene NPTX2 neurons. In mouse model AD...