A5067430944- Dementia and Cognitive Impairment Research
- Health disparities and outcomes
- Urban Transport and Accessibility
- Urban Green Space and Health
- Alzheimer's disease research and treatments
- Noise Effects and Management
- Migration, Aging, and Tourism Studies
- Frailty in Older Adults
- Health, Environment, Cognitive Aging
- Urban, Neighborhood, and Segregation Studies
- Geriatric Care and Nursing Homes
- Climate Change and Health Impacts
- Urban Heat Island Mitigation
- Aging and Gerontology Research
- Older Adults Driving Studies
- Spinal Dysraphism and Malformations
- Neurological Disease Mechanisms and Treatments
- Prenatal Screening and Diagnostics
- Land Use and Ecosystem Services
- Blood Pressure and Hypertension Studies
- Cholinesterase and Neurodegenerative Diseases
- Parkinson's Disease Mechanisms and Treatments
- Air Quality and Health Impacts
- Folate and B Vitamins Research
- Intracerebral and Subarachnoid Hemorrhage Research
University of Miami
2022-2025
Authorised Association Consortium
2023
Landscape Research Group
2023
Florida Atlantic University
2018-2021
Atlantic University
2018-2021
University of Washington
2012-2020
Lifespan
2018-2019
University of North Carolina at Chapel Hill
2008-2017
University of Southern California
2017
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2017
The neuropsychological battery of the Uniform Data Set (UDSNB) was implemented in 2005 by National Institute on Aging (NIA) Alzheimer Disease Centers program to measure cognitive performance dementia and mild impairment due Disease. This paper describes a revision, UDSNB 3.0.
We aimed to estimate the prevalence of Down syndrome (DS) among children and adolescents aged 0 19 years in 10 regions United States.This study was a cross-sectional analysis live-born infants with DS during 1979-2003 from population-based birth defects registries States. estimated at each region all pooled. The calculated overall according age group, race/ethnicity, infant gender, presence major heart defect.From 1979 through 2003, increased by 31.1%, 9.0 11.8 per 10000 live births US...
Neuropathologic evaluation remains the gold standard for determining presence and severity of aging-related neurodegenerative diseases. Researchers at U.S. Alzheimer's Disease Centers (ADCs) have worked >30 years studying human brains, with goals achieving new research breakthroughs. Harmonization sharing among 39 current past ADCs is promoted by National Coordinating Center (NACC), which collects, audits, disburses ADC-derived data to investigators on request. The decades witnessed revised...
Introduction: Four new nonproprietary tests were recommended for use in the National Alzheimer’s Coordinating Center’s Uniform Data Set Neuropsychological Battery. These are similar to previous but also allow continuity of longitudinal data collection and wide dissemination among research collaborators. Methods: A Crosswalk Study was conducted early 2014 assess correlation between each set tests. Tests with good equated using equipercentile equating. The resulting conversion tables scores on...
Compared to Caucasians, African Americans (AAs) have higher dementia prevalence, different genetic markers, and vascular risk factors. However, pathologic underpinnings are unknown.We used neuropathologic clinical data on 110 AA 2500 Caucasians who were demented before death. The groups compared regarding demographics, cognition, apolipoprotein E (APOE) genotype, comorbidities, characteristics.AA differed in their cognition at the last visit death, APOE presence of hypertension, primary...
The goal was to estimate the number of children and adolescents, 0 19 years age, living with spina bifida (SB) in United States.A retrospective study conducted by using population-based, birth defect surveillance data from 10 US regions, vital status ascertainment. Birth were obtained Arkansas, Georgia (5 central counties metropolitan Atlanta), California (11 counties), Colorado, Iowa, New York (New City excluded), North Carolina, Oklahoma, Texas, Utah. We estimated numbers age who SB...
White matter hyperintensities (WMH) on magnetic resonance imaging (MRI) have been postulated to be a core feature of Alzheimer's disease. Clinicopathological studies are needed elucidate and confirm this possibility.This study examined: 1) the association between antemortem WMH autopsy-confirmed disease neuropathology (ADNP), 2) relationship dementia in participants with ADNP, 3) relationships among cerebrovascular disease, WMH, ADNP.The sample included 82 from National Coordinating Center's...
Abstract Introduction Recent research with neuropathologic or biomarker evidence of Alzheimer's disease (AD) casts doubt on traumatic brain injury (TBI) as a risk factor for AD. We leveraged the National Coordinating Center to examine association between self‐reported TBI loss consciousness and AD changes, baseline longitudinal clinical status. Methods The sample included 4761 autopsy participants (453 remote consciousness; 2822 changes) from Center. Results Self‐reported did not predict...
Identifying asymptomatic older individuals at elevated risk for developing Alzheimer disease (AD) is of clinical importance. Among 1,081 adults, a recently validated polygenic hazard score (PHS) significantly predicted time to AD dementia and steeper longitudinal cognitive decline, even after controlling APOE ɛ4 carrier status. Older in the highest PHS percentiles showed incidence rates. decline among with moderate high Consortium Establish Registry Alzheimer's Disease (amyloid) Braak (tau)...
<h3>Objective:</h3> To conduct a clinicopathologic study to characterize clinical and neuropathologic features associated with cognitive impairment in participants no neuritic amyloid plaques (primary age-related tauopathy [PART] definite) sparse (amyloid sparse). <h3>Methods:</h3> Using the National Alzheimer9s Coordinating Center database, we identified 377 individuals who were PART definite (n = 170) or 207), clinically examined within 1 year of death, autopsied at 26 Institute on...
Primary age-related tauopathy is increasingly recognized as a separate neuropathological entity different from Alzheimer's disease. Both share the features of tau aggregates and neuronal loss in temporal lobe, but primary lacks requisite amyloid plaques central to While both have similar clinical presentations, individuals with symptomatic are commonly more advanced ages milder cognitive dysfunction. Direct comparison neuropsychological trajectories disease has not been thoroughly evaluated...
Introduction: We investigated whether cholinesterase inhibitors (ChEIs) benefit cognitive outcomes in mild impairment due to Alzheimer disease (MCI-AD) and AD dementia (ADdem). Methods: Data from 2242 individuals, clinically diagnosed with MCI-AD [Clinical Dementia Rating (CDR), 0 or 0.5] ADdem (CDR, 0.5 1), were available the National Alzheimer’s Coordinating Center’s (NACC) Uniform Set (UDS). General linear mixed models used examine annual change CDR Sum of Boxes (CDR-SB)...
Ambient air pollution, detrimental built and social environments, isolation (SI), low socioeconomic status (SES), rural (versus urban) residence have been associated with cognitive decline risk of Alzheimer's disease related dementias (ADRD). Research is needed to investigate the influence ambient pollution environments on SI among rural, disadvantaged, ethnic minority communities. To address this gap, cohort study will recruit an ethnoracially diverse, Florida sample in geographic proximity...
Declining physical functionality is an indicator of cognitive impairment, distinguishing normal cognition (NC) from dementia. Whether this extends to pre-dementia stages unclear. Assess performance patterns, evaluate relationships with imaging biomarkers, and identify specific measures NC, subjective decline (SCD) mild impairment (MCI). Group differences (78 35 SCD, 41 MCI) in function (global function, balance, gait speed, step length, single leg support) were evaluated logistic regression...