A5037010654- Dementia and Cognitive Impairment Research
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Alzheimer's disease research and treatments
- Genetic Associations and Epidemiology
- EEG and Brain-Computer Interfaces
- Neuroscience and Music Perception
- Health, Environment, Cognitive Aging
- Hearing Loss and Rehabilitation
- Advanced MRI Techniques and Applications
- Nutritional Studies and Diet
- Neural dynamics and brain function
- Diet and metabolism studies
- Neural and Behavioral Psychology Studies
- Alcohol Consumption and Health Effects
- Bioinformatics and Genomic Networks
- Multisensory perception and integration
- MRI in cancer diagnosis
- Birth, Development, and Health
- Blood Pressure and Hypertension Studies
- Substance Abuse Treatment and Outcomes
- Cerebrovascular and Carotid Artery Diseases
- Neurological Disease Mechanisms and Treatments
- Memory and Neural Mechanisms
- Liver Disease Diagnosis and Treatment
University of California, San Diego
2016-2025
Kaiser Permanente Washington Health Research Institute
2023-2025
Human Longevity (United States)
2021-2025
Kaiser Permanente
2024
Seattle University
2024
Wake Forest University
2024
Health Data Research UK
2023
University of Cambridge
2023
Alzheimer’s Disease Neuroimaging Initiative
2023
Union Bank of Switzerland
2023
Changes in cortical activity during working memory tasks were examined with electroencephalograms (EEGs) sampled from 115 channels and spatially sharpened magnetic resonance imaging (MRI)-based finite element deblurring. Eight subjects performed requiring comparison of each stimulus to a preceding one on verbal or spatial attributes. A frontal midline theta rhythm increased magnitude load. Dipole models localized this signal the region anterior cingulate cortex. slow (low-frequency),...
An accurate description of changes in the brain healthy aging is needed to understand basis age-related cognitive function. Cross-sectional magnetic resonance imaging (MRI) studies suggest thinning cerebral cortex, volumetric reductions most subcortical structures, and ventricular expansion. However, there a paucity detailed longitudinal support cross-sectional findings. In present study, 142 elderly participants (60–91 years age) were followed with repeated MRI, compared 122 patients mild...
We assessed working memory load during computer use with neural network pattern recognition applied to EEG spectral features. Eight participants performed high-, moderate-, and low-load tasks. Frontal theta activity increased alpha decreased increasing load. These changes probably reflect task difficulty-related increases in mental effort the proportion of cortical resources allocated performance. In analyses, test data segments from high low levels were discriminated better than 95%...
Inappropriate response tendencies may be stopped via a specific fronto/basal ganglia/primary motor cortical network. We sought to characterize the functional role of two regions in this putative stopping network, right inferior frontal gyrus (IFG) and primary cortex (M1), using electocorticography from subdural electrodes four patients while they performed stop-signal task. On each trial, was initiated, on minority trials stop signal instructed patient try response. For patient, there...
To determine the neurocognitive effects of continuous positive airway pressure (CPAP) therapy on patients with obstructive sleep apnea (OSA).The Apnea Positive Pressure Long-term Efficacy Study (APPLES) was a 6-month, randomized, double-blind, 2-arm, sham-controlled, multicenter trial conducted at 5 U.S. university, hospital, or private practices. Of 1,516 participants enrolled, 1,105 were and 1,098 diagnosed OSA contributed to analysis primary outcome measures.Active sham CPAP MEASUREMENTS:...
Background Identifying individuals at risk for developing Alzheimer disease (AD) is of utmost importance. Although genetic studies have identified AD-associated SNPs in APOE and other genes, information has not been integrated into an epidemiological framework prediction. Methods findings Using genotype data from 17,008 AD cases 37,154 controls the International Genomics Alzheimer's Project (IGAP Stage 1), we (at p < 10−5). We then these a Cox proportional hazard model using subset 6,409...
Several lines of evidence suggest that genome-wide association studies (GWAS) have the potential to explain more "missing heritability" common complex phenotypes. However, reliable methods identify a larger proportion single nucleotide polymorphisms (SNPs) impact disease risk are currently lacking. Here, we use genetic pleiotropy-informed conditional false discovery rate (FDR) method on GWAS summary statistics data new loci associated with schizophrenia (SCZ) and bipolar disorders (BD), two...
To use structural magnetic resonance (MR) images to identify a pattern of regional atrophy characteristic mild Alzheimer disease (AD) and investigate whether presence this prospectively can aid prediction 1-year clinical decline increased loss in cognitive impairment (MCI).The study was conducted with institutional review board approval compliance HIPAA regulations. Written informed consent obtained from each participant. High-throughput volumetric segmentation cortical surface...
Recent genome-wide association studies (GWAS) and pathway analyses supported long-standing observations of an between immune-mediated diseases Parkinson disease (PD). The post-GWAS era provides opportunity for cross-phenotype different complex phenotypes.To test the hypothesis that there are common genetic risk variants conveying both PD autoimmune (ie, pleiotropy) to identify new shared their pathways by applying a novel statistical framework in approach.Using conjunction false discovery...
To evaluate the spatial pattern and regional rates of neocortical atrophy from normal aging to early Alzheimer disease (AD).Longitudinal MRI data were analyzed using high-throughput image analysis procedures for 472 individuals diagnosed as normal, mild cognitive impairment (MCI), or AD. Participants divided into 4 groups based on Clinical Dementia Rating Sum Boxes score (CDR-SB). Annual derived by calculating percent cortical volume loss between baseline 12-month scans. Repeated-measures...
<h3>BACKGROUND AND PURPOSE:</h3> Different biomarkers for AD may potentially be complementary in diagnosis and prognosis of AD. Our aim was to combine MR imaging, FDG-PET, CSF the diagnostic classification 2-year MCI AD, by examining following: 1) which measures are most sensitive status, 2) what extent methods provide unique information classification, 3) predictive clinical decline. <h3>MATERIALS METHODS:</h3> ADNI baseline data from 42 controls, 73 patients with MCI, 38 AD; follow-up 36...
Alzheimer's disease (AD) has a slow onset, so it is challenging to distinguish brain changes in healthy elderly persons from incipient AD. One-year with distinct frontotemporal pattern have been shown older adults. However, not clear what extent these may affected by undetected, early To address this, we estimated 1-year atrophy magnetic resonance imaging (MRI) 132 who had remained free of diagnosed mild cognitive impairment or AD for at least 3 years. We found significant volumetric...
Converging evidence implicates immune abnormalities in schizophrenia (SCZ), and recent genome-wide association studies (GWAS) have identified immune-related single-nucleotide polymorphisms (SNPs) associated with SCZ. Using the conditional false discovery rate (FDR) approach, we evaluated pleiotropy SNPs SCZ (n=21,856) multiple sclerosis (MS) (n=43,879), an inflammatory, demyelinating disease of central nervous system. Because bipolar disorder (BD) show substantial clinical genetic overlap,...
Abstract Introduction Alzheimer's Disease Neuroimaging Initiative (ADNI) is now in its 10th year. The primary objective of the magnetic resonance imaging (MRI) core ADNI has been to improve methods for clinical trials disease (AD) and related disorders. Methods We review contributions MRI from present past cycles (ADNI‐1, ‐Grand Opportunity ‐2). also plans future‐ADNI‐3. Results Contributions include creating standardized acquisition protocols quality control methods; examining effect...
Working memory (WM), the ability to briefly retain and manipulate information in mind, is central intelligent behavior. Here we take advantage of high temporal resolution electrophysiological measures obtain a millisecond timescale view activity induced distributed cortical networks by tasks that impose significant WM demands. We examined how these are affected type amount be remembered, task practice. Evoked potentials (EPs) were obtained from eight subjects performing spatial verbal...
Infrequent "deviant' auditory stimuli embedded in a homogeneous sequence of "standard' sounds evoke neuromagnetic mismatch field (MMF), which is assumed to reflect automatic change detection the brain. We investigated whether MMFs would reveal hemispheric differences cortical processing. Seven healthy adults were studied with whole-scalp neuromagnetometer. The sound sequence, delivered one ear at time, contained three infrequent deviants (differing from standards duration, frequency, or...
Abstract Noninvasive MRI biomarkers for Alzheimer's disease (AD) may enable earlier clinical diagnosis and the monitoring of therapeutic effectiveness. To assess potential neuroimaging biomarkers, Disease Neuroimaging Initiative is following normal controls (NC) individuals with mild cognitive impairment (MCI) or AD. We applied high‐throughput image analyses procedures to these data demonstrate feasibility detecting subtle structural changes in prodromal Raw DICOM scans (139 NC, 175 MCI, 84...
This study examined how sleep loss affects neurophysiologic signals related to attention and working memory.
Brain atrophy and altered CSF levels of amyloid β (Aβ 42 ) the microtubule-associated protein tau are potent biomarkers Alzheimer's disease (AD)-related pathology. However, relationship between brain morphometry is poorly understood. Thus, we addressed following questions. (1) Can biomarker explain morphometric differences normal controls (NC) patients with mild cognitive impairment (MCI) or AD? (2) How related to across brain? (3) closely clinical change [clinical dementia rating sum boxes...