A5023405914- Functional Brain Connectivity Studies
- Dementia and Cognitive Impairment Research
- Advanced Neuroimaging Techniques and Applications
- Memory and Neural Mechanisms
- Advanced MRI Techniques and Applications
- Neural and Behavioral Psychology Studies
- Alzheimer's disease research and treatments
- Health, Environment, Cognitive Aging
- Birth, Development, and Health
- Memory Processes and Influences
- Neural dynamics and brain function
- Cognitive Abilities and Testing
- Sleep and related disorders
- Sleep and Wakefulness Research
- EEG and Brain-Computer Interfaces
- Neonatal and fetal brain pathology
- Diet and metabolism studies
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Fetal and Pediatric Neurological Disorders
- Identity, Memory, and Therapy
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurobiology of Language and Bilingualism
- Attention Deficit Hyperactivity Disorder
- Neurogenesis and neuroplasticity mechanisms
University of Oslo
2016-2025
Oslo University Hospital
2016-2025
Norwegian University of Science and Technology
2004-2024
Lifespan
2013-2023
Max Planck Institute for Human Development
2023
657 Oslo
2022
Czech Academy of Sciences, Institute of Psychology
2022
Centre for Life
2021
University College London
2018
Birkbeck, University of London
2018
Magnetic resonance imaging volumetry studies report inverted U-patterns with increasing white-matter (WM) volume into middle age suggesting protracted WM maturation compared the cortical gray matter. Diffusion tensor (DTI) is sensitive to degree and direction of water permeability in biological tissues, providing vivo indices microstructure. The aim this cross-sectional study was delineate trajectories DTI 430 healthy subjects ranging 8-85 years age. We used automated regional brain...
The development of cortical gray matter, white matter (WM) volume, and WM microstructure in adolescence is beginning to be fairly well characterized by structural magnetic resonance imaging (sMRI) diffusion tensor (DTI) studies. However, these aspects brain have rarely been investigated concurrently the same sample hence relations between them are not understood. We delineated age-related changes thickness, regional characteristics relationships properties development. One hundred...
Cross-sectional magnetic resonance imaging (MRI) studies of cortical thickness and volume have shown age effects on large areas, but there are substantial discrepancies across regarding the localization magnitude effects. These hinder understanding aging brain morphometry, limit potential usefulness MR in research healthy pathological age-related changes. The present study was undertaken to overcome this problem by assessing consistency 6 different samples with a total 883 participants. A...
An accurate description of changes in the brain healthy aging is needed to understand basis age-related cognitive function. Cross-sectional magnetic resonance imaging (MRI) studies suggest thinning cerebral cortex, volumetric reductions most subcortical structures, and ventricular expansion. However, there a paucity detailed longitudinal support cross-sectional findings. In present study, 142 elderly participants (60–91 years age) were followed with repeated MRI, compared 122 patients mild...
Human cortical thickness and surface area are genetically independent, emerge through different neurobiological events during development, sensitive to clinical conditions. However, the relationship between changes in two over time is unknown. Additionally, longitudinal studies have almost invariably been restricted older adults, precluding delineation of adult life span trajectories change structure. In this study, we investigated thickness, area, volume after an average interval 3.6 years...
Brain development during late childhood and adolescence is characterized by decreases in gray matter (GM) increases white (WM) ventricular volume. The dynamic nature of across different structures is, however, not well understood, the present magnetic resonance imaging study took advantage a whole-brain segmentation approach to describe developmental trajectories 16 neuroanatomical volumes same sample children, adolescents, young adults ( n = 171; range, 8–30 years). cerebral cortex, WM,...
Older adults exhibit global reductions in cortical surface area, but little is known about the regional patterns of or how these relate to other measures brain structure. This knowledge critical understanding dynamic relationship between different macrostructural properties cortex throughout adult life. Here, arealization, local gyrification index (LGI), and thickness were measured vertex wise across 322 healthy (20-85 years), with aims 1) characterizing age three separate 2) testing...
Several theories link processes of development and aging in humans. In neuroscience, one model posits for instance that healthy age-related brain degeneration mirrors development, with the areas thought to develop later also degenerating earlier. However, intrinsic evidence such a between structure remains elusive. Here, we show data-driven analysis structural variation across 484 participants (8-85 y) reveals largely--but not only--transmodal network whose lifespan pattern change...
It is well established that human brain white matter structure changes with aging, but the timescale and spatial distribution of this change remain uncertain. Cross-sectional diffusion tensor imaging (DTI) studies indicate that, after a period relative stability during adulthood, there an accelerated decline in anisotropy increase diffusivity values senescence; and, spatially, results have been discussed within context several anatomical frameworks. However, inferring trajectories from...
Does accelerated cortical atrophy in aging, especially areas vulnerable to early Alzheimer's disease (AD), unequivocally signify neurodegenerative or can it be part of normal aging? We addressed this 3 ways. First, age trajectories thickness were delineated cross-sectionally (n = 1100) and longitudinally 207). Second, effects undetected AD on the simulated by mixing sample with a patients very mild moderate AD. Third, AD-vulnerable regions was examined older adults low probability incipient...
Significance Here we show that developmental and adult aging-related changes in cortical thickness follow closely the genetic organization of cerebral cortex. A total 1,633 MRI scans from 974 participants 4.1 to 88.5 y age were used measure longitudinal thickness, topographic pattern change was compared with relationship between subdivisions maximal shared influence, obtained an independent sample 406 middle-aged twins. Cortical due maturation adhered cortex, indicating individual...
Cerebral myelin maturation and aging-related degradation constitute fundamental features of human brain integrity functioning. Although mostly studied in the white matter, cerebral cortex contains significant amounts myelinated axons. However, how intracortical content evolves during development, decays aging, links with cognition remain poorly understood. Several studies have shown potential mapping by use T1-weighted (T1w) T2-weighted (T2w) magnetic resonance imaging signal intensity,...
<h3>BACKGROUND AND PURPOSE:</h3> Different biomarkers for AD may potentially be complementary in diagnosis and prognosis of AD. Our aim was to combine MR imaging, FDG-PET, CSF the diagnostic classification 2-year MCI AD, by examining following: 1) which measures are most sensitive status, 2) what extent methods provide unique information classification, 3) predictive clinical decline. <h3>MATERIALS METHODS:</h3> ADNI baseline data from 42 controls, 73 patients with MCI, 38 AD; follow-up 36...
A growing body of research indicates benefits cognitive training in older adults, but the neuronal mechanisms underlying effect intervention remains largely unexplored. Neuroimaging methods are sensitive to subtle changes brain structure and show potential for enhancing our understanding both aging- training-related plasticity. Specifically, studies using diffusion tensor imaging (DTI) suggest substantial white matter (WM) aging, it is not known whether might modulate these structural...
Alzheimer's disease (AD) has a slow onset, so it is challenging to distinguish brain changes in healthy elderly persons from incipient AD. One-year with distinct frontotemporal pattern have been shown older adults. However, not clear what extent these may affected by undetected, early To address this, we estimated 1-year atrophy magnetic resonance imaging (MRI) 132 who had remained free of diagnosed mild cognitive impairment or AD for at least 3 years. We found significant volumetric...