A5059859995- EEG and Brain-Computer Interfaces
- Neural dynamics and brain function
- Neurological disorders and treatments
- Neuroscience and Neural Engineering
- Functional Brain Connectivity Studies
- Neural and Behavioral Psychology Studies
- Parkinson's Disease Mechanisms and Treatments
- Mental Health Research Topics
- Heart Rate Variability and Autonomic Control
- Memory Processes and Influences
- Transcranial Magnetic Stimulation Studies
- Genetic Neurodegenerative Diseases
- Health, Environment, Cognitive Aging
- Neuroscience and Music Perception
- Behavioral and Psychological Studies
- Nicotinic Acetylcholine Receptors Study
- Muscle activation and electromyography studies
- Advanced MRI Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Botulinum Toxin and Related Neurological Disorders
- Attention Deficit Hyperactivity Disorder
- Smoking Behavior and Cessation
- Analog and Mixed-Signal Circuit Design
- Blind Source Separation Techniques
- Memory and Neural Mechanisms
University of Oregon
2018-2024
Neurological Surgery
2014-2018
University of California, San Francisco
2014-2018
University of California, San Diego
2009-2012
Response inhibition is essential for navigating everyday life. Its derailment considered integral to numerous neurological and psychiatric disorders, more generally, a wide range of behavioral health problems. Response-inhibition efficiency furthermore correlates with treatment outcome in some these conditions. The stop-signal task an tool determine how quickly response implemented. Despite its apparent simplicity, there are many features (ranging from design data analysis) that vary across...
Inappropriate response tendencies may be stopped via a specific fronto/basal ganglia/primary motor cortical network. We sought to characterize the functional role of two regions in this putative stopping network, right inferior frontal gyrus (IFG) and primary cortex (M1), using electocorticography from subdural electrodes four patients while they performed stop-signal task. On each trial, was initiated, on minority trials stop signal instructed patient try response. For patient, there...
Objective. Contemporary deep brain stimulation (DBS) for Parkinson's disease is delivered continuously, and adjustments based on patient's changing symptoms must be made manually by a trained clinician. Patients may subjected to energy intensive settings at times when they are not needed, possibly resulting in stimulation-induced adverse effects, such as dyskinesia. One solution 'adaptive' DBS, which modified real time neural signals that co-vary with the severity of motor signs or effects....
Hyperkinetic states are common in human movement disorders, but their neural basis remains uncertain. One such condition is dyskinesia, a serious adverse effect of medical and surgical treatment for Parkinson9s disease (PD). To study this, we used novel, totally implanted, bidirectional interface to obtain multisite long-term recordings. We focus our analysis on two patients with PD who experienced frequent dyskinesia studied them both at rest during voluntary movement. show that associated...
Stopping an initiated response could be implemented by a fronto-basal-ganglia circuit, including the right inferior frontal cortex (rIFC) and subthalamic nucleus (STN). Intracranial recording studies in humans reveal increase beta-band power (approximately 16-20 Hz) within rIFC STN when is stopped. This suggests that important for communication this network. If case, then altering one region should affect electrophysiological at other. We addressed hypothesis scalp EEG during stop task while...
The Brain Imaging Data Structure (BIDS) is a community-driven specification for organizing neuroscience data and metadata with the aim to make datasets more transparent, reusable, reproducible. Intracranial electroencephalography (iEEG) offer unique combination of high spatial temporal resolution measurements living human brain. To improve internal (re)use external sharing these data, we present storing iEEG data: iEEG-BIDS.
Parkinson disease (PD) can be difficult to diagnose and treat. Development of a biomarker for PD would reduce these challenges by providing an objective measure disease. Emerging theories suggest is characterized excessive synchronization in the beta frequency band (∼20Hz) throughout basal ganglia-thalamocortical loops. Recently we showed with invasive electrocorticography that one robust this coupling phase broadband gamma amplitude (ie, phase-amplitude [PAC]). Other recent work suggests...
OBJECTIVE Dysfunction of distributed neural networks underlies many brain disorders. The development neuromodulation therapies depends on a better understanding these networks. Invasive human recordings have favorable temporal and spatial resolution for the analysis network phenomena but generally been limited to acute intraoperative recording or short-term through temporarily externalized leads. Here, authors describe their initial experience with an investigational, first-generation,...
Neural activity in the β frequency range (13-30 Hz) is excessively synchronized Parkinson's disease (PD). Previous work using invasive intracranial recordings and non-invasive scalp electroencephalography (EEG) has shown that correlations between phase broad-band γ (>50 amplitude [i.e., coupling (PAC)] are elevated PD, perhaps a reflection of this synchrony. Recently, it also been shown, human recordings, non-sinusoidal features oscillation shape characterize PD. Here, we show these waveform...
OBJECTIVE Contemporary theories of the pathophysiology movement disorders emphasize abnormal oscillatory activity in basal ganglia-thalamocortical loops, but these have been studied humans mainly using depth recordings. Recording from surface cortex electrocorticography (ECoG) provides a much higher amplitude signal than recordings, is less susceptible to deep brain stimulation (DBS) artifacts, and yields surrogate measure population spiking via "broadband gamma" (50-200 Hz) activity....
Preparing to stop an inappropriate action requires keeping in mind the task goal and using this influence control system. We tested hypothesis that different subregions of prefrontal cortex show temporal profiles consistent with dissociable contributions preparing-to-stop, dorsolateral (DLPFC) representing ventrolateral (VLPFC) implementing control. Five human subjects were studied electrocorticography recorded from subdural grids over right lateral frontal cortex. On each trial, a cue...
In Parkinson's disease patients in the OFF medication state, basal ganglia local field potentials exhibit changes beta and gamma oscillations that correlate with reduced voluntary movement, manifested as rigidity akinesia. However, magnetoencephalography low-resolution electrocorticography (ECoG) studies suggest sensorimotor cortical differ from those of ganglia. To more clearly define role cortex oscillatory activity Parkinson's, we performed intraoperative, high-resolution (4 mm spacing)...
Response inhibition is essential for navigating everyday life. Its derailment considered integral to numerous neurological and psychiatric disorders, more generally, a wide range of behavioral health problems. Response-inhibition efficiency furthermore correlates with treatment outcome in these conditions. The stop-signal task an tool determine how quickly response implemented. Despite its apparent simplicity, there are many features (ranging from design data analysis) that vary across...
Background Many adaptative deep brain stimulation (DBS) paradigms rely upon the ability to sense neural signatures of specific clinical signs or symptoms in order modulate therapeutic stimulation. In first-generation bidirectional neurostimulators, signals during active was often limited by artifact. Newer devices, with improved design specifications for sensing, have recently been developed and are now clinically available. Objective To compare sensing capabilities Medtronic PC + S...
The objective of this study was to evaluate proposed electroencephalographic (EEG) biomarkers Parkinson’s disease (PD) and test their correlation with motor impairment in a new, well-characterized cohort PD patients controls. Sixty-four-channel EEG recorded from 14 rigid-akinetic minimal tremor age-matched healthy controls at rest during voluntary movement. Patients were tested off on medication single session. Recordings analyzed for phase-amplitude coupling over sensorimotor cortex...
Parkinson's disease (PD) is characterized by motor symptoms such as rigidity and bradykinesia that prevent normal movement. Beta band oscillations (13-30 Hz) in neural local field potentials (LFPs) have been associated with these symptoms. Here, three PD patients implanted a therapeutic deep brain stimulator can also record wirelessly stream data played neurofeedback game where they modulated their beta power from sensorimotor cortical areas. Patients' was streamed real-time to update the...
Abstract Flexible, adaptive behavior is critically dependent on inhibitory control. For example, if you suddenly notice are about to step a tack and would prefer not to, the ability halt your ongoing movement critical. However, this usually probed by current control tasks, which often focus instead inhibiting before its initiation. To address limitations in existing approaches for studying termination of an movement, we developed novel stop task with can directly observe compare prepared...
Intracranial electrophysiology analysis requires precise location and anatomical labeling of electrode recording contacts before a signal processing the data can be interpreted.Signal techniques are common to other modalities, such as magnetoencephalography (MEG) electroencephalography (EEG), so ideally locating intracranial electrodes would an integrated part single software package.This work covers addition localization intracranial-specific analyses MNE-Python (Gramfort et al., 2013)...