A5077007979- Neurological disorders and treatments
- EEG and Brain-Computer Interfaces
- Neuroscience and Neural Engineering
- Epilepsy research and treatment
- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- Vagus Nerve Stimulation Research
- Neuroscience and Neuropharmacology Research
- Transcranial Magnetic Stimulation Studies
- stochastic dynamics and bifurcation
- Advanced MRI Techniques and Applications
- Neural Networks and Applications
- Pain Mechanisms and Treatments
- Pain Management and Treatment
- Sleep and Wakefulness Research
- Parkinson's Disease Mechanisms and Treatments
- Cerebrospinal fluid and hydrocephalus
- Memory Processes and Influences
- Memory and Neural Mechanisms
- Neurobiology and Insect Physiology Research
- Visual perception and processing mechanisms
- Cognitive Functions and Memory
- Advanced Memory and Neural Computing
- Muscle activation and electromyography studies
- Photoreceptor and optogenetics research
Mayo Clinic in Arizona
2019-2025
Mayo Clinic
2016-2025
WinnMed
2018-2025
BioElectronics (United States)
2021-2024
Columbia University
2024
Quantitative BioSciences
2024
University of Toronto
2021
Kazan Federal University
2021
Henry Ford Hospital
2020
Johns Hopkins University
2020
<h3>Objective</h3> To prospectively evaluate safety and efficacy of brain-responsive neurostimulation in adults with medically intractable focal onset seizures (FOS) over 9 years. <h3>Methods</h3> Adults treated 2-year feasibility or randomized controlled trials were enrolled a long-term prospective open label trial (LTT) to assess safety, efficacy, quality life (QOL) an additional 7 Safety was assessed as adverse events (AEs), median percent change seizure frequency responder rate, QOL the...
Coupling of cerebral blood flow (CBF) and metabolic rate for oxygen (CMRO(2)) in physiologically activated brain states remains the subject debates. Recently it was suggested that CBF is tightly coupled to oxidative metabolism a nonlinear fashion. As part this hypothesis, mathematical models delivery have been described which disproportionately large increases are necessary sustain even small CMRO(2) during activation. We explored coupling by using two complementary methods. First, more...
The Brain Imaging Data Structure (BIDS) is a community-driven specification for organizing neuroscience data and metadata with the aim to make datasets more transparent, reusable, reproducible. Intracranial electroencephalography (iEEG) offer unique combination of high spatial temporal resolution measurements living human brain. To improve internal (re)use external sharing these data, we present storing iEEG data: iEEG-BIDS.
OBJECTIVE Deep brain stimulation (DBS) of the anterior nucleus thalamus (ANT) is a promising therapy for refractory epilepsy. Unfortunately, variability in outcomes from ANT DBS not fully understood. In this pilot study, authors assess potential differences functional connectivity related to volume tissue activated (VTA) responders and nonresponders as means better understanding mechanism action potentially improving targeting. METHODS This retrospective analysis consisted 6 patients who...
The centromedian (CM) and anterior nucleus of the thalamus (ANT) are deep brain stimulation (DBS) targets for management generalized, focal drug resistant epilepsy (DRE), respectively. We report on a single center retrospective case series 16 children adults with DRE who underwent CM simultaneous ANT (69 %) or without DBS (31 %). Seizure frequency, severity, life satisfaction, quality sleep before after were compared. Baseline median seizure frequency was 323 seizures per month (IQR, 71–563...
Abstract Chronic brain recordings suggest that seizure risk is not uniform, but rather varies systematically relative to daily (circadian) and multiday (multidien) cycles. Here, one human seven dogs with naturally occurring epilepsy had continuous intracranial EEG (median 298 days) using novel implantable sensing stimulation devices. Two pet the subject received concurrent thalamic deep (DBS) over multiple months. All subjects circadian cycles in rate of interictal epileptiform spikes (IES)....
Abstract Deep brain stimulation and responsive neurostimulation (RNS) use high‐frequency (HFS) per the pivotal trials manufacturer‐recommended therapy protocols. However, not all patients respond to HFS. In this retrospective case series, 10 implanted with RNS System were programmed low‐frequency (LFS) treat their seizures; nine of these previously treated HFS (100 Hz or greater). LFS was defined as frequency < Hz. Burst duration increased at least 1000 ms. With HFS, had a median seizure...
Abstract Early implantable epilepsy therapy devices provided open-loop electrical stimulation without brain sensing, computing, or an interface for synchronized behavioural inputs from patients. Recent provide sensing but have not yet developed analytics accurately tracking and quantifying behaviour seizures. Here we describe a distributed co-processor providing intuitive bi-directional between patient, implanted neural device, local computing resources. Automated analysis of continuous...
Electrical deep brain stimulation (DBS) is an established treatment for patients with drug-resistant epilepsy. Sleep disorders are common in people epilepsy, and DBS may actually further disturb normal sleep patterns quality. Novel implantable devices capable of streaming continuous intracranial electroencephalography (iEEG) signals enable detailed assessments therapy efficacy tracking related comorbidities. Here, we investigate the feasibility automated classification using iEEG data...
BACKGROUND AND OBJECTIVES: Epilepsy is considered one of the most prevalent and severe chronic neurological disorders worldwide. Our study aims to analyze national trends in different treatment modalities for individuals with drug-resistant epilepsy investigate outcomes associated these procedural United States. METHODS: Using National Inpatient Sample database from 2010 2020, patients focal who underwent laser interstitial thermal therapy (LITT), open surgical resection, vagus nerve...
The role of irregular cortical firing in neuronal computation is still debated, and it unclear how signals carried by fluctuating synaptic potentials are decoded downstream neurons. We examined vitro frequency versus current ( f–I ) relationships layer 5 (L5) pyramidal cells the rat medial prefrontal cortex (mPFC) using stimuli. Studies somatosensory show that L5 neurons become insensitive to input fluctuations as mean increases their response becomes linear. In contrast, our results mPFC...
Adaptive processes over many timescales endow neurons with sensitivity to stimulus changes a similarly wide range of scales. Although spike timing single can precisely signal rapid fluctuations in their inputs, the mean firing rate convey information about slower-varying properties stimulus. Here, we investigate response slowly varying envelope whisker motion two processing stages rat vibrissa pathway. The whiskers anesthetized rats were moved through noise trajectory an amplitude that was...
When medically intractable epilepsy is multifocal or focal but poorly localized, neuromodulation can be useful therapy. One such technique deep brain stimulation (DBS) targeting the anterior nucleus of thalamus (ANT). Unfortunately, ANT difficult to visualize in standard MRI sequences and its indirect because thalamic variability atrophy patients with epilepsy. The following study describes novel use fast gray matter acquisition T1 inversion recovery (FGATIR) sequence delineate...
Abstract There is a paucity of data to guide anterior nucleus the thalamus (ANT) deep brain stimulation (DBS) with sensing. The clinical Medtronic Percept DBS device provides constrained sensing power within frequency band (power‐in‐band [PIB]), recorded in 10‐min averaged increments. Here, four patients temporal lobe epilepsy were implanted an investigational providing full bandwidth chronic intracranial electroencephalogram (cEEG) from bilateral ANT and hippocampus (Hc). PIB‐based seizure...
Direct cortical stimulation has been applied in epilepsy for nearly one century and experienced a renaissance given unprecedented opportunities to probe, excite inhibit the human brain. Evidence suggests can increase diagnostic therapeutic utility patients with drug-resistant epilepsies. However, choosing appropriate parameters is not trivial issue, which further complicated by fact that characterized complex brain state dynamics. In this article derived from discussions at ICTALS 2022...