A5070479055- Neurological disorders and treatments
- Food Quality and Safety Studies
- Neuroscience and Neural Engineering
- Coffee research and impacts
- EEG and Brain-Computer Interfaces
- Phytochemicals and Antioxidant Activities
- Nutrition, Health and Food Behavior
- Genetic Neurodegenerative Diseases
- Tea Polyphenols and Effects
- Epilepsy research and treatment
- Advanced MRI Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Parkinson's Disease Mechanisms and Treatments
- Fermentation and Sensory Analysis
- Agriculture, Soil, Plant Science
- Pharmacological Effects of Natural Compounds
- Protein Hydrolysis and Bioactive Peptides
- Photoreceptor and optogenetics research
- Food Chemistry and Fat Analysis
- Neuroendocrine regulation and behavior
- Ginseng Biological Effects and Applications
- Infant Health and Development
- Healthcare and Venom Research
- Meat and Animal Product Quality
- Aquaculture Nutrition and Growth
WinnMed
2012-2025
Mayo Clinic
2012-2024
Mayo Clinic in Arizona
2018-2024
Sunchon National University
2022-2023
Food & Nutrition
2023
BioElectronics (United States)
2021-2022
Mayo Clinic in Florida
2014-2022
Dankook University
2018-2021
Brain stimulation has emerged as an effective treatment for a wide range of neurological and psychiatric diseases. Parkinson's disease, epilepsy, essential tremor have FDA indications electrical brain using intracranially implanted electrodes. Interfacing implantable devices with local cloud computing resources the potential to improve efficacy, disease tracking, management. Epilepsy, in particular, is that might benefit from integration implants off-the-body tracking therapy. Recent...
The combination of deep brain stimulation (DBS) and functional MRI (fMRI) is a powerful means tracing circuitry testing the modulatory effects electrical on neuronal network in vivo. goal this study was to trace DBS-induced global activation large animal model by monitoring blood oxygenation level-dependent (BOLD) response fMRI. We conducted DBS normal anesthetized pigs, targeting subthalamic nucleus (STN) (n = 7) entopeduncular (EN), non-primate analog primate globus pallidus interna 4)....
Essential tremor is often markedly reduced during deep brain stimulation simply by implanting the stimulating electrode before activating neurostimulation. Referred to as microthalamotomy effect, mechanisms of this unexpected consequence are thought be related microlesioning targeted tissue, that is, a microscopic version tissue ablation in thalamotomy. An alternate possibility induces immediate neurochemical release. Herein, we report experiment performing with real-time fast-scan cyclic...
Summary Objective Seizures are currently defined by their electrographic features. However, neuronal networks intrinsically dependent on neurotransmitters of which little is known regarding periictal dynamics. Evidence supports adenosine as having a prominent role in seizure termination, its administration can terminate and reduce seizures animal models. Furthermore, microdialysis studies humans suggest that elevated periictally, but the relationship to obscured temporal measurement...
ObjectiveTo test the hypothesis suggested by previous studies that subthalamic nucleus (STN) deep brain stimulation (DBS) in patients with Parkinson disease would affect activity of motor and nonmotor networks, we applied intraoperative functional magnetic resonance imaging (fMRI) to receiving DBS.Patients MethodsTen STN DBS for underwent 1.5-T fMRI during high-frequency delivered via an external pulse generator. The study was conducted between January 1, 2013, September 30, 2014.ResultsWe...
Abstract Chronic brain recordings suggest that seizure risk is not uniform, but rather varies systematically relative to daily (circadian) and multiday (multidien) cycles. Here, one human seven dogs with naturally occurring epilepsy had continuous intracranial EEG (median 298 days) using novel implantable sensing stimulation devices. Two pet the subject received concurrent thalamic deep (DBS) over multiple months. All subjects circadian cycles in rate of interictal epileptiform spikes (IES)....
Abstract Early implantable epilepsy therapy devices provided open-loop electrical stimulation without brain sensing, computing, or an interface for synchronized behavioural inputs from patients. Recent provide sensing but have not yet developed analytics accurately tracking and quantifying behaviour seizures. Here we describe a distributed co-processor providing intuitive bi-directional between patient, implanted neural device, local computing resources. Automated analysis of continuous...
Conventional deep brain stimulation (DBS) devices continue to rely on an open-loop system in which is independent of functional neural feedback. The authors previously proposed that as the foundation a DBS "smart" device, closed-loop based neurochemical feedback, may have potential improve therapeutic outcomes. Alterations release are thought be linked clinical benefit DBS, and fast-scan cyclic voltammetry (FSCV) has been shown effective for recording these evoked changes. However,...
Background Deep Brain Stimulation (DBS) of the nucleus accumbens (NAc) has previously been investigated clinically for treatment several psychiatric conditions, including obsessive-compulsive disorder and resistant depression. However, mechanism underlying therapeutic benefit DBS, brain areas that are activated, remains largely unknown. Here, we utilized 3.0 T functional Magnetic Resonance Imaging (fMRI) changes in Blood Oxygenation Level-Dependent (BOLD) signal to test hypothesis...
Translational animal models are essential for advancing neuromodulation therapies drug-resistant epilepsy. Large epilepsy that accommodate implantable devices designed humans needed to advance electrical brain stimulation and sensing applicaitons. We establish a kainic acid (KA) porcine model of mesial temporal lobe (mTLE) pre-clinical research development novel stimulating therapies. developed platform integrating MRI-guided stereotactic electrode chemotoxin delivery with intraoperative...
Rationale: Optogenetics offers unmatched cellular specificity and control over activity. Various opsins have been tested in animal models of epilepsy, each contributing to our understanding seizure circuit dynamics. However, inhibitory optogenetic tools based on microbial rhodopsins low light sensitivity and, thus, are less suitable for applications involving larger brains. We evaluated eOPN3, a red-shifted, highly sensitive G- protein coupled receptor opsin porcine model using integrated...
In this study, we investigated the physicochemical and antioxidative properties of traditional Korean confectionery, Yanggaeng, when various amounts tempeh powder (TP) were added.We replaced a portion white bean paste in Yanggaeng with TP at percentages 0% (CON), 2% (TP2), 4% (TP4), 6% (TP6) by total weight.The proximate composition results showed that TP6 exhibited highest crude ash protein contents, but its moisture content carbohydrate lowest compared to CON.Tempeh addition altered...
Histamine is among the most poorly understood biogenic amines, yet histaminergic system spreads throughout brain and has been implicated in functions as diverse homeostasis synaptic plasticity. Not surprisingly then, it linked to a number of conditions including minimally conscious state, persistent vegetative epilepsy, addiction, cluster headache, essential tremor, Parkinson's disease. We have previously reported that Wireless Instantaneous Neurotransmitter Concentration Sensing (WINCS) can...
Although fast-scan cyclic voltammetry (FSCV) has contributed to important advances in neuroscience research, the technique is encumbered by significant analytical challenges. Confounding factors such as pH change and transient effects at microelectrode surface make it difficult discern analytes represented complex voltammograms. Here we introduce paired-pulse (PPV), that mitigates confounding simplifies task. PPV consists of a selected binary waveform with specific time gap between each its...
Deep brain stimulation (DBS) within the basal ganglia complex is an effective neurosurgical approach for treating symptoms of Parkinson's disease (PD), Essential Tremor, Dystonia, Depression, Obssessive Compulsive Disorder, and Tourette's Syndrome, among others. Elucidating DBS mechanism has become a critical clinical research goal in stereotactic functional neurosurgery neural engineering. Along with electro-physiological microdialysis techniques, two additional powerful technologies,...
The cutaneous wound healing process is tightly regulated by a range of cellular responses, including migration. Sphingosine-1-phosphate (S1P) signaling lipid produced in keratinocytes (KC) and it known to stimulate skin repair through increased KC Of the multifunctional triterpene ginsenosides, Rb1 enhances increasing migration, but mechanisms responsible for Rb1-mediated increase migration are largely unknown. Therefore, we hypothesized that, assessed whether, could S1P-dependent...
Recent technical developments brought negative side effects such as air pollution and large-scale fires, increasingly exposing people to diesel engine exhaust particles (DEP). Testing how DEP inhalation triggers pathophysiology in animal models could be useful determining it affects humans. To this end, the aim of study was investigate pulmonary exposure for seven consecutive days experimental male C5BL6/N mice. Twenty-four mice were treated with one three test materials: distilled water...
Abstract Early implantable epilepsy therapy devices provided open-loop electrical stimulation without brain sensing, computing, or an interface for synchronized behavioral inputs from patients. Recent provide sensing but have not yet developed analytics accurately tracking and quantifying behavior seizures. Here we describe a distributed co-processor providing intuitive bi-directional between patient, implanted neural device, local computing resources. Automated analysis of continuous...
This study aimed to investigate the beneficial effects of Momordica charantia (MC) extract and MC fermented with Leuconostoc mesenteroides MKSR (FMC) on high-fat high-cholesterol diet-induced metabolic complications. Male C57BL/6 mice were divided into six groups: normal diet (ND), (HFCD), HFCD 1% (HFCD + 1M), 4% 4M), 1F), 4F). After 12 weeks dietary intervention, consumption L. resulted in significant decreases white adipose tissue weights (epididymal retroperitoneal tissue), serum alanine...
Extraction from edible plants is a highly important process that has various biological functions. To maximize activity, extraction methods should facilitate optimal of functional phytochemicals. In this study, the hydrothermal conditions Acer tegmentosum were determined using response surface methodology (RSM), and HepG2 cells treated with optimized extract hydrogen peroxide. central composition design, independent variables temperature (X1: 70–90 °C), time (X2: 2–6 h), solvent-to-solid...
The objective of this research was to investigate the quality characteristics spirits by different distillation and filtrations. contents alcohol, total acids, amino acids in rice mash were 15%, 0.25 g/100 mL, 0.15 respectively. soluble content 10°Brix, pH 4.6 mash. Lactic acid most prominent organic found spirit distilled a multi stage distiller showed highest amounts aroma compounds, such as fusel oil esters. However, filtration did not affect compounds. It is suggested that may influence...